Overview
An overdose of Aspirin can be acute or chronic. Acute develops with a single dose of Aspirin in a dose of more than 4000 - 5000 mg, and chronic - when it is taken in an amount of more than 100 mg per 1 kg of body weight per day for two consecutive days, or with long-term use of relatively large quantities. Acute and chronic overdose of Aspirin is manifested by the same complex of symptoms, which, depending on their severity, determine moderate or severe degrees of intoxication.
For mild and moderate overdose of Aspirin, the following manifestations are characteristic:
- Dizziness;
- Noise in ears;
- Hearing impairment;
- Increased sweating;
- Nausea;
- Vomiting
- Headache;
- Confusion;
- Rapid breathing.
Treatment of mild and moderate overdose with Aspirin consists in repeated use of sorbents (activated charcoal, Polysorb, Polyphepan, etc.), gastric lavage and diuretics with a parallel replenishment of the volume of lost fluid and salts.
Severe overdose of Aspirin is manifested by the following symptoms:
- Very high body temperature;
- Respiratory depression;
- Pulmonary edema;
- Asphyxia;
- Arrhythmia;
- Drop in blood pressure;
- Inhibition of the heart;
- Violation of the water-electrolyte balance;
- Dehydration;
- Impaired renal function, up to failure;
- Increase or decrease in blood glucose;
- Ketoacidosis;
- Noise in ears;
- Deafness;
- Gastrointestinal bleeding;
- Violation of blood coagulability from lengthening the bleeding time to the complete absence of a blood clot;
- Encephalopathy
- CNS depression (drowsiness, confusion, coma and cramps).
Severe overdose with Aspirin must be treated exclusively in the intensive care unit of the hospital. At the same time, the same manipulations are performed as with moderate and Yosprala intoxication, but at the same time maintaining the work of vital organs and systems.
Interaction with other drugs
only here enhances the action of the following drugs while taking it:
- Methotrexate;
- Heparin and indirect anticoagulants (e.g., warfarin, thrombostop, etc.);
- Thrombolytics (drugs that dissolve blood clots), anticoagulants (drugs to reduce blood coagulation) and antiplatelet agents (drugs that prevent blood clots by preventing platelet adhesion);
- Selective serotonin reuptake inhibitors (e.g., fluoxetine, sertraline, paroxetine, citalopram, escitalopram, etc.);
- Digoxin;
- Drugs for lowering blood glucose (hypoglycemic agents) for oral administration;
- Insulin;
- Valproic acid;
- Drugs open link the NSAID group (Ibuprofen, Nimesulide, Diclofenac, Ketonal, Indomethacin, etc.);
- Ethanol.
Given the enhanced effects of these drugs, while taking Aspirin, it is necessary to reduce their therapeutic dosage.
It should be remembered that when taking Aspirin with anticoagulants, thrombolytics, antiplatelet agents, use that serotonin reuptake inhibitors and alcoholic beverages, the risk of bleeding and ulceration of the gastric mucosa increases. Taking Aspirin with other NSAID drugs increases the risk of side effects and bleeding from the digestive tract.
In addition, Aspirin may reduce the therapeutic effect of the following drugs:
- Diuretics;
- ACE inhibitors (Berlipril, Captopril, Lisinopril, Perindopril, etc.);
- Drugs with the ability to remove uric acid from the body (Probenecid, Benzbromaron, etc.).
The effects of Aspirin are attenuated when taken concomitantly with drugs containing ibuprofen, as well as glucocorticosteroid hormones.
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Aspirin for children
Children with influenza, acute respiratory viral infections and chickenpox are not recommended to give Aspirin, since the drug can provoke the development of Reye's syndrome, which is a very serious CNS lesion with liver failure. Death occurs in half of the children with Reye's syndrome. The risk of developing this syndrome with the use of Aspirin exists only in children under 15 years of age, therefore, all drugs containing acetylsalicylic acid are not recommended to be given to them before this age.
In the developed countries of Europe and the USA, Aspirin is banned for children under 15 years old from the 80s of the last century, and in Russia such Yosprala ban does not exist. Therefore, the undesirability of the use of Aspirin in children under 15 years of age is reduced solely to the recommendations.
In order to reduce body temperature, relieve pain and reduce the severity of the inflammatory process for children under 15 years of age, it is recommended to use preparations containing ibuprofen or paracetamol, since they are safer.
Pregnancy
Aspirin can have a negative effect on the course of pregnancy and fetal development, therefore its use is strictly prohibited in the first and third trimesters (from 1 to 13 and from 28 to 40 weeks of gestation). In the first trimester, the drug can provoke heart defects and splitting of the upper palate in the fetus, and in the third - inhibition of labor, prolongation of pregnancy and intracranial hemorrhage in a child.
During the second trimester of pregnancy, Aspirin can be used only when there is an urgent need, when it is not possible to replace it with another drug, and the benefit to the mother clearly exceeds the risks to the fetus. The maximum allowable dosage of Aspirin in the second trimester of pregnancy is 150 mg per day.
Aspirin penetrates into milk in an insignificant amount, which does not cause any adverse reactions in the child. Therefore, when taking Aspirin in small doses for a short period of time, you do not need to stop breastfeeding and transfer the baby to the mixture. However, if aspirin is taken in high dosages or https://zentherapycenter.com/let-y/ypozane.php a long period of time, then breast-feeding should be discontinued.
Facial Aspirin for Acne (mask with Aspirin)
Aspirin in the form of an external agent applied to the skin of the face is very successfully used by dermatologists for the treatment of inflammatory processes, including acne, acne, etc. Currently, especially for the cosmetic industry and the practice of dermatologists, aspirin is available in the form of powders, pastes and solutions, which are used in the complex treatment of inflammatory processes of the skin. Face masks with Aspirin have the following effects:
- Cleanses the skin and removes black spots;
- Reduces fat production by skin glands;
- Narrows pores;
- Reduces inflammation on the skin;
- Prevents the formation of acne and acne;
- Eliminates edema;
- Eliminates acne marks;
- Exfoliates dead epidermal cells;
- Keeps skin supple.
At home, the most simple and effective method of using Aspirin to improve the structure of the skin and eliminate acne are masks with this drug. For their preparation, you can use ordinary tablets without a shell, purchased at a pharmacy. A face mask with Aspirin is a mild version of chemical peeling, so it is recommended to do it no more than 2 to 3 times a week, and during the day after applying the cosmetic procedure, do not be in direct sunlight.
Consider the various options for Aspirin masks for various skin types:
one. For oily and very oily skin. The mask cleanses pores, soothes the skin and reduces inflammation. Grind 4 Aspirin tablets into powder and mix it with a tablespoon of water, add a teaspoon of honey and vegetable oil (olive, sunflower, etc.). Apply the resulting mixture to the face and massage it with massaging movements for 10 minutes, then rinse with warm water.
2. For normal to dry skin. The mask reduces inflammation and soothes the skin. Grind 3 Aspirin tablets and mix with a tablespoon of yogurt. Apply the finished mixture to the face, leave for 20 minutes and rinse with warm water.
3. For problem skin with a lot of inflammation. The mask effectively reduces inflammation and prevents the appearance of new acne. To prepare the mask, several Aspirin tablets are crushed and poured with water until a thick slurry is formed, which is applied pointwise to acne or acne and left for 20 minutes, then washed off.
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