Buy Generic Xerese On line

Warnings

Acyclovir is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Herpes can be passed to your baby during childbirth if you have a genital lesion when your baby is born. If you have genital herpes, it is very important to prevent herpes lesions during pregnancy. Take your medicine as directed to best control your infection.

Interactions

TiZANidine: CYP1A2 Inhibitors (Weak) may increase the serum concentration of TiZANidine. Management: Avoid these combinations when possible. If combined use is necessary, initiate tizanidine at an adult dose of 2 mg and increase in 2 to 4 mg increments based on patient response. Monitor for increased effects of tizanidine, including adverse reactions. Consider therapy modification

Zoster Vaccine (Live/Attenuated): Acyclovir-Valacyclovir may diminish the therapeutic effect of Zoster Vaccine (Live/Attenuated). Management: When possible, discontinue antiviral agents with anti-zoster activity (i.e., acyclovir, valacyclovir, famciclovir) for at least 24 hours prior to and 14 days after receiving a live attenuated zoster vaccine. Avoid combination

Mycophenolate: Acyclovir-Valacyclovir may increase the serum concentration of Mycophenolate. Mycophenolate may increase the serum concentration of Acyclovir-Valacyclovir. Monitor therapy

Food interaction

Take without regard to meals.

Increase liquid intake.

Pregnancy

• Pregnancy should also be avoided for one month after stopping treatment.
• Studies of pregnant women in their second and third trimesters have not shown any negative effects.
• However, in rats, there was a decrease in pup weight, an increase in stillborn pups, and an increase in pup deaths during the first 5 days of lactation, when dosing began during pregnancy and continued until weaning.

Overview

• Digestive system - jaundice, hepatitis, abdominal pain;
• The hematopoietic system - anemia, hyperbilirubinemia, thrombocytopenia, erythropenia, leukopenia;
• Central nervous system - drowsiness, tremor, agitation, ataxia, confusion, encephalopathy, hallucinations, Xerese, convulsions, psychotic symptoms, coma;
• Respiratory System - Dyspnea.

Of the allergic reactions, the most likely development of skin rash, urticaria, itching, Lyell and Stevens-Johnson syndrome, as well as anaphylactic reactions.

Among other side effects of Acyclovir tablets, visual impairment, peripheral edema, myalgia, lymphadenopathy, malaise are possible.

The use of eye ointment Acyclovir practically does not cause undesirable effects. In rare cases, minor allergic reactions are possible in the form of immediate-type hypersensitivity, conjunctivitis, pinpoint superficial keratopathy, mild burning, blepharitis, which does not require drug withdrawal.

Acyclovir external ointment can cause soreness, itching, vulvitis, burning, skin rash, allergic reactions and edema at the site of application.

Terms and conditions of storage

The medicine Acyclovir, according to the instructions, refers to antiviral prescription drugs with a shelf life of:

• Acyclovir tablets - 2 years;
• Eye and external ointment Acyclovir - 3 years. The medicine must be used within a month after opening.

In this article, you can read the instructions for using the drug Acyclovir. Provides feedback from visitors to the site - consumers of this medicine, as well as the opinions of medical specialists on the use of Acyclovir in their practice. A big request is to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, possibly not announced by the manufacturer in the annotation. Analogs of Acyclovir in the presence of available structural analogues. Use for the treatment of oral and genital herpes in adults, children, as well as during pregnancy and lactation. Trademarks for various acyclovir options: Acre, HEXAL, AKOS.

Acyclovir - antiviral drug, a synthetic analogue of thymidine nucleoside, which has a highly selective effect on herpes viruses. Inside the virus-infected cells, a series of sequential reactions of the transformation of acyclovir into acyclovir mono- di- and triphosphate undergoes a viral thymidine kinase. Acyclovir triphosphate integrates into the viral DNA chain and blocks Xerese synthesis through competitive inhibition of viral DNA polymerase.

The specificity and very high selectivity of the action is also due to its predominant accumulation in cells affected by the herpes virus. Highly active against Herpes simplex virus type 1 and 2; chickenpox virus and herpes zoster (Varicella zoster); Epstein-Barr virus (types of viruses are listed in increasing order of magnitude of the minimum inhibitory concentration of acyclovir). Moderately active against cytomegalovirus.

With herpes, it prevents the formation of new elements of the rash, reduces the likelihood of skin dissemination and visceral complications, accelerates the formation of crusts, and reduces pain in the acute phase of herpes zoster.

Pharmacokinetics

After oral administration, the bioavailability is 15-30%, while dose-dependent concentrations Xerese created that are sufficient for the effective treatment of viral diseases. Food does not significantly affect the absorption of acyclovir. Acyclovir penetrates well into many organs, tissues and body fluids. Acyclovir crosses the blood-brain and placental barriers, accumulates in breast milk. About 84% is excreted by the kidneys unchanged, 14% - in the form of a metabolite. Less than 2% of acyclovir is excreted through the intestines.

Indications

• treatment of infections of the skin and mucous membranes caused by Herpes simplex viruses of types 1 and 2 (genital and oral herpes), both primary and secondary, including genital herpes;
• prevention of exacerbations of recurrent infections caused by Herpes simplex types 1 and 2 in patients with normal immune status;
• prevention of primary and recurrent infections caused by Herpes simplex viruses of types 1 and 2 in patients with immunodeficiency;
• as part of the complex therapy of patients with severe immunodeficiency: with HIV infection (AIDS stage, early clinical manifestations and an expanded clinical picture) and in patients undergoing bone marrow transplantation;
• treatment of primary and recurrent infections caused by the Varicella zoster virus (chickenpox and herpes zoster - Herpes zoster).

Release Forms

200 mg tablets.