Rocuronium may also be used for purposes not listed in this medication guide.
Rocuronium Sandoz is a drug made in Australia, Poland. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Rocuronium is a complete analogue of Rocuronium Sandoz. It has the same composition, dosage and methods of use. Also Rocuronium has a lower cost compared to Rocuronium Sandoz.
To buy Rocuronium Sandoz, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Tell your doctor about any unusual or bothersome side effect. ongoing muscle weakness; or ongoing muscle weakness; or myasthenia gravis; cirrhosis or other liver disease; heart disease, circulation problems; or a history of kidney disease;
Warnings
It is not known whether rocuronium will harm an unborn baby. Tell your doctor if you are pregnant.
Tell your doctor if you are breast-feeding a baby.
Tell your doctor if you have ever had:
- myasthenia gravis;
- cirrhosis or other liver disease;
- kidney disease;
- heart disease, circulation problems; or
- a nerve-muscle disorder such as ALS (Lou Gehrig's disease), MS (multiple sclerosis), or muscular dystrophy.
Interactions
Cardiac Glycosides: Neuromuscular-Blocking Agents may enhance the arrhythmogenic effect of Cardiac Glycosides. Monitor therapy
Trimebutine: May enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents (Nondepolarizing). Monitor therapy
Tetracyclines: May enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Monitor therapy
Food interaction
Pregnancy
- US have problems getting pregnant, or carrying a pregnancy full term.
- If you think you may be pregnant, tell your doctor right away.
Overview
Pharmacokinetics
It binds to plasma proteins by 30%. Penetrates through the placental barrier.
After a single injection of rocuronium bromide in the form of a bolus, the dependence of its concentration in plasma on Rocuronium was exponential and consisted Rocuronium three phases. In healthy adults, average T1/2 (95% CI) is 73 (66-80) minutes, the apparent volume of distribution in equilibrium is 203 (193-214) ml / kg, and the clearance from plasma is 3.7 (3.5-3.9) ml / kg / min.
Plasma clearance in the elderly and patients with impaired renal function is slightly reduced compared to that in younger people with normal renal function. In patients with liver disease, the average period of T1/2 by 30 minutes, and the average clearance from plasma is reduced by 1 ml / kg / min.
The volume of distribution in newborns (3-12 months) is higher than in older children (1-8 years) and adults.
In children aged 3-8 years, clearance is higher, and T1/2 about 20 minutes shorter than adults and children under 3 years old.
With continuous infusions for 20 hours or more during mechanical ventilation, average T1/2 and the average volume of distribution in equilibrium increases.
High interindividual variability is noted, associated with the nature and degree of multiple organ failure and individual debility of patients. In patients with multiple organ failure, average T1/2 (± SD) was 21.5 (± 3.3) h, the volume of distribution in the equilibrium state was 1.5 (± 0.8) l / kg. clearance from plasma - 2.1 (± 0.8) ml / kg / min. Rocuronium bromide is excreted in urine and bile.
The degree of excretion in urine reaches 40% within Sandoz hours, 47% is excreted in the feces. Approximately 50% of the dose is excreted as rocuronium bromide. No plasma metabolites detected.
Indications
It is used in adults and children older than 3 months:
- during general anesthesia, to facilitate tracheal intubation with standard and rapid sequential induction of anesthesia;
- for muscle relaxation during surgery.
Intensive care units (ICUs) for short-term muscle relaxation (e.g. to facilitate intubation).
Contraindications
- anaphylactic reactions to rocuronium or bromine in the anamnesis;
- children's age up to 3 months.
Side effects
By frequency, undesirable effects are divided into the following categories:
Non-depolarizing muscle relaxant with a short (closer to average) duration of action. It is a competitive antagonist of acetylcholine in relation to n-cholinergic receptors of neuromuscular synapses of skeletal muscle. Virtually no ganglion-blocking and m-anticholinergic action, slightly affects the release of histamine. It can cause tachycardia (in 30% of cases), the effect on heart rate is less pronounced than for pancuronium bromide, and more than for vecuronium bromide.
ED 90 (the dose required to suppress 90% the contractility of the thumb muscle to stimulate the ulnar nerve) with iv general anesthesia is approximately 0.3 mg / kg body weight. After iv administration at a dose of 0.6 mg / kg (2 × ED 90), complete neuromuscular blockade is achieved after 60-70 seconds; general relaxation of skeletal muscles, adequate for any surgical procedures, within 2 min; the clinical Sandoz of action (time to spontaneous recovery Sandoz skeletal muscle contractility up to 25% of the control level) is 30-40 minutes; the Rocuronium time of spontaneous recovery of contractility from 25 to 75% of the control level (recovery index) - 14 min; total duration (time to spontaneous recovery of skeletal muscle contractility to 90% of the control level) - 50 min.
The time to reach the maximum effect depends on the dose, age and choice of type of anesthetic.
I / O only. The dose is set individually, depending on the clinical situation.
From the cardiovascular system: less often - a decrease or increase in blood pressure; rarely - arrhythmia (including tachycardia).
From the digestive system: rarely - hiccups, nausea, vomiting.
Allergic reactions: rarely - angioedema, skin rash, bronchospasm, shortness of breath.
Local reactions: swelling and pain at the injection site (with extravasation).
