Methotrexate is usually given after other medications have been tried without successful treatment of symptoms.
Methoblastin is a drug made in Australia, New Zealand. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Methotrexate is a complete analogue of Methoblastin. It has the same composition, dosage and methods of use. Also Methotrexate has a lower cost compared to Methoblastin.
To buy Methoblastin, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Tell your doctor about any unusual or bothersome side effect. stuffy or runny nose and sore throat headaches you’ve had a recent vaccination lack of appetite sore throat you have a current infection yellowing of the skin or eyes, known as jaundice blood in your stool, or black, tarry stool
Warnings
Do not give this medicine to a child without the advice of a doctor.
You should not breast-feed while using this medicine.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because methotrexate may harm the baby if a pregnancy does occur.
Interactions
Vaccines (Inactivated): Immunosuppressants may diminish the therapeutic effect of Vaccines (Inactivated). Management: Vaccine efficacy may be reduced. Complete all age-appropriate vaccinations at least 2 weeks prior to starting an immunosuppressant. If vaccinated during immunosuppressant therapy, revaccinate at least 3 months after immunosuppressant discontinuation. Consider therapy modification
Teriflunomide: May increase the serum concentration of OAT1/3 Substrates. Monitor therapy
P-glycoprotein/ABCB1 Inducers: May decrease the serum concentration of P-glycoprotein/ABCB1 Substrates. P-glycoprotein inducers may also further limit the distribution of p-glycoprotein substrates to specific cells/tissues/organs where p-glycoprotein is present in large amounts (e.g., brain, T-lymphocytes, testes, etc.). Monitor therapy
Food interaction
Take without regard to meals. Limit caffeine intake.
Milk appears to reduce its absorption.
Pregnancy
- You must have two negative pregnancy tests before starting this medication.
- Pregnancy should not be planned while you or your partner are on this therapy.
- Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.
Overview
Protective therapy is started 8-24 hours before the start of the main other. Doses of calcium folinate are determined depending on the volume of the dropper:
- When receiving 100-150 mg within 12-24 hours, 150 mg of folate is administered, then another 12-25 mg of calcium in injections or 15 mg orally every 6 hours for 2 days.
- For doses below 100 mg, 1 capsule of folinate should be taken every 6 hours for 2–3 days.
Methotrexate Injections
Intravenous, intramuscular or intraarterial injections are prescribed for trophoblastic tumors, leukemia, rheumatoid arthritis. Before the introduction of the drug, part of the cerebrospinal fluid is removed in the volume in which the medicine will be administered. After opening the ampoule, the medication remains stable for 24 hours, after which the drug should be disposed of. Injections for rheumatoid arthritis are prescribed 1 time per week, while the drug is administered on the same day and time.
How to take methotrexate for rheumatoid arthritis
The effect of the drug in the treatment of chronic joint inflammation is presumably associated with its ability to suppress immunity. Using this medication allows you to restore joint function, reduce inflammation and the symptoms associated with arthrosis - swelling, stiffness of joints, severe pain. There is no unified regimen.
To cure arthritis, doctors prescribe a minimum dosage of 6.5 mg. Then, after two to three weeks of therapy, the dose is gradually increased, reaching 26 mg. The recommended dosage is adhered to throughout the treatment, and the dosage regimen of Methoblastin drug in tablets remains the same as for the drug in injections - 1 time per week. Sometimes the daily dosage is divided into two or three doses, which must be carried out Methoblastin an interval of 12 hours.
The effect of treatment for arthritis and arthrosis is not achieved immediately, but 5-6 months after the start of therapy. If the clinical effect is too slow, the drug Methoblastin combined with other agents. They treat rheumatoid arthritis with methotrexate and folic acid or a medicine:
- cyclosporine;
- leflunomide;
- hydroxychloroquine;
- sulfasalazine.
Treatment of lymphoma and leukemia
The drug is administered intravenously, intramuscularly, intralumbally. Children with a diagnosis of leukemia should preferably Methoblastin given orally with water. For adults, the optimal dosage for injection is 200-500 mg per m2 (body surface area). An injection is made 1 time per week, as with arthrosis or arthritis. Sometimes prescribed 2.5-5-10 mg daily for 5 days. Active components affect the division of malignant tissues without harming healthy cells. The use of the medication helps to achieve long-term remission.
With psoriasis and mycosis
To prescribe the drug in the treatment of psoriasis or mycosis in the chronic stage, the patient should have a skin lesion of at least 20% and a decrease in the sensitivity of the pathogenic flora to other local medicines or photochemistry. With psoriasis, tablets are prescribed in dosages of up to 25 mg per week. With fungal mycosis of the skin or nails, solutions are used that are administered 50 mg once intramuscularly.
Neuroleukemia treatment
The method of administration of methotrexate for neuroleukemia is intralumbar injections and irradiation of the head in doses up to 2400 rad. The drug is administered 1-2 times every 7 days in dosages of 12 mg per m2 of body area. In the presence of extraosseous foci of autoimmune inflammation, which provoke the appearance of severe pain and compress nearby organs, an additional local radiation therapy with dosages of 500-2500 rad.
special instructions
The drug can only be prescribed by an oncologist who has experience in chemotherapy. The patient must be informed in advance of the risk of developing serious adverse reactions that can lead to disability and death. If the patient has fluid in the abdominal or pleural cavity, it must be removed before treatment. If symptoms of stomatitis appear, stop using this medication. Before prescribing methotrexate, blood tests must be done.
If surgery is necessary, the drug should be discontinued 1 week before the appointed date for surgical interventions and restarted after 14 days. Women of reproductive age must be informed about the negative effect of the drug on the fetus and recommend effective contraceptives. During treatment, it is necessary to approach with caution to perform work that requires an increased concentration of attention.
During pregnancy
