Clarithromycin is a macrolide antibiotic that fights bacteria in your body.
Klacid-MR is a drug made in Hong Kong, Malaysia, Serbia, Thailand, Turkey. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Clarithromycin is a complete analogue of Klacid-MR. It has the same composition, dosage and methods of use. Also Clarithromycin has a lower cost compared to Klacid-MR.
To buy Klacid-MR, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Careful monitoring by your doctor may decrease your risk. In some instances, hepatic failure with fatal outcome has been reported, generally in association with serious underlying diseases or concomitant medications Not for use in pregnancy, except when there is no alternative therapy; apprise patient about potential hazard to fetus if pregnancy occurs while in therapy Oral solution must not be refrigerated Use caution in patients with coronary artery disease; postmarketing trials suggest increased risk of cardiovascularmortality Exacerbation of myasthenia gravis or new onset of symptoms reported Increased liver enzyme activity and hepatocellular or cholestatic hepatitis, with or without jaundice, have been reported; this may be severe and is usually reversible Hepatic dysfunction No information available
Warnings
Some medicines can cause unwanted or dangerous effects when used with clarithromycin. Your doctor may need to change your treatment plan if you use any of the following drugs:
- cisapride;
- pimozide;
- lovastatin or simvastatin; or
- ergotamine or dihydroergotamine.
This medicine is not approved for use by anyone younger than 6 months old.
In animal studies, clarithromycin caused birth defects. However, it is not known whether these effects would occur in humans. Ask your doctor about your risk.
Interactions
Cabazitaxel: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Cabazitaxel. Management: Concurrent use of cabazitaxel with strong inhibitors of CYP3A4 should be avoided when possible. If such a combination must be used, consider a 25% reduction in the cabazitaxel dose. Consider therapy modification
Piperaquine: QT-prolonging Strong CYP3A4 Inhibitors (Moderate Risk) may enhance the QTc-prolonging effect of Piperaquine. QT-prolonging Strong CYP3A4 Inhibitors (Moderate Risk) may increase the serum concentration of Piperaquine. Management: Consider alternatives to this drug combination. If combined, monitor for QTc interval prolongation and ventricular arrhythmias. Patients with additional risk factors for QTc prolongation may be at even higher risk. Consider therapy modification
Cannabis: CYP3A4 Inhibitors (Strong) may increase the serum concentration of Cannabis. More specifically, tetrahydrocannabinol and cannabidiol serum concentrations may be increased. Monitor therapy
Food interaction
Biaxin XL - take with a meal, taking it on an empty stomach is associated with total product exposure 30% inferior to that observed when administered with food.
Biaxin - take without regard to meals (however absorption appears to be improved when drug is taken with food).
Pregnancy
- It is important for women who could get pregnant to discuss pregnancy and methods of contraception with their doctor before starting treatment with this medicine.
- Call your healthcare provider if you miss your period, because you might be pregnant.
- You are pregnant or plan to become pregnant.
Overview
Instructions for use clarithromycin
How to take clarithromycin in the form of tablets or capsules?
Clarithromycin is sold in pharmacies in the form of tablets of 250 mg or 500 mg, as well as 250 mg capsules. A single and daily dose is always selected individually. The standard dosage regimen involves the use of capsule mg to 1000 mg once. In this case, the same dose of the drug in tablets should be taken both in the morning and in the evening. The maximum daily dose for adults is 2 grams of clarithromycin, for children - 1 gram. A tablet or capsule should be taken without chewing with a sufficient amount of water. It is advisable that the pill be separated from the meal.
High doses of the drug are required to treat severe infections such as chronic sinusitis, pneumonia, and infection caused by mycobacteria. In such cases, 1 gram of antibiotic is prescribed 2 times a day. The standard dose for most infections in adults is 500 mg 2 times a day. In patients with chronic renal failure, a dose of not more than 250 mg twice a day is used.
The drug look be taken before or after a meal.?
A feature of the active substance of this drug is a slowdown in absorption from the gastrointestinal tract while eating. Because of this, the drug goes into the blood longer and has a healing effect more slowly. Despite this, the drug does not break down during this time, and in general, the effectiveness of the drug does not decrease.
Given this feature, it is recommended that the interval between taking the antibiotic and food is about 1 hour. Do not take it during or immediately after a meal. It is best to eat well, wait about an hour, and only after that take a pill. Taking a pill on an empty stomach is also not recommended, because starvation decreases blood sugar, which can cause a fainting condition.
Does the drug have a bitter taste?
How long do you need to continue with clarithromycin?
The duration of treatment with clarithromycin is usually from 6 to 14 days. In practice, the duration of drug treatment is determined by the doctor after a clinical examination and assessment of the severity of the disease. So, with otitis, the duration of treatment can be from 5 to 7 days. In the treatment of acute bacterial bronchitis, the periods are extended to 10-14 days. In the case of treatment of gastritis and peptic ulcer, an antibiotic must be taken for 14 days. Finally, there are some regimens for using clarithromycin (e.g. treatment of mycobacteria or chronic sinusitis) in which antibiotic treatment lasts up to six months.
If a person has kidney or liver disease, you can not continue the course for more than 14 days. In other cases, the patient should not independently interrupt the course of treatment, for example, at the first improvement of his condition or in the absence of positive changes in the first two days of using the drug. Such a short use of the antibiotic leads to the fact that a small part of the microorganisms is retained in the body, which also acquires resistance to clarithromycin. As a result, the disease returns with more dangerous symptoms, and more potent antibiotics are required to treat it.
Clarithromycin treatment regimen for eradication (removal) Helicobacter
Removing Helicobacter bacteria from the gastrointestinal tract and treating gastritis and peptic ulcer is one of the main uses of clarithromycin. To perform this complex task, the use of several drugs is required, and not only antibiotics. Doctors concluded that at the moment there is no one regimen that gives a positive result in all cases, so several treatment options have been developed that can be used if others are ineffective. The basis of therapy is an antibiotic (clarithromycin).
The most Klacid-MR eradication pattern (removal) Helicobacter consists of the following drugs:
- Proton Pump Inhibitor (omeprazole, 20 mg 2 times a day). It is used to reduce the formation of hydrochloric acid, which damages the weakened mucous membrane of the stomach.
- Clarithromycin (500 mg 2 times a day). The main antibacterial agent against Helicobacter pylori.
- Amoxicillin (1000 mg 2 times a day) or metronidazole (500 mg 2 times a day). An additional component with a different mechanism of action.
This treatment usually lasts 7 days, after which the diagnostic tests for the presence of bacteria in the gastrointestinal tract are repeated. If necessary, this scheme is adjusted, increasing its
for treating (
up to 14 days) or adding new components (
bismuth preparations that promote ulcer healing) If antibiotics show complete inefficiency (
bacterial contamination does not decrease or decreases slightly), then they switch to stronger antibiotics (
tetracycline or doxycycline in combination with metronidazole) Sometimes antibiotic treatment has to be repeated, since Helicobacter infection can occur when eating conventional foods.
How to use the drug intravenously?
The intravenous use of clarithromycin can only be performed by people with a medical background. Patients should not be administered this drug intravenously on their own. This is due to the fact that this method of using the drug requires sterile conditions and good manual skills for intravenous injections. As a rule, intravenous use of clarithromycin is Klacid-MR only in medical hospitals. If the patient is treated at home, the doctor prescribes the drug in the form of tablets.
Intravenous administration of clarithromycin usually involves the use of 1 gram of antibiotic per day, divided into 2 equal doses. Bottle Contents (powder) is dissolved in physiological saline (volume from 250 ml to 500 ml) and is administered through a dropper for 60 minutes or more into the superficial veins of the forearm. Faster administration is prohibited, since the drug is poorly soluble in water and physiological saline. Preparation of the solution, finding and puncture of the vein is carried out by medical personnel. Intravenous administration is used in patients with severe bacterial infections. After 2 to 5 days of treatment, they are transferred to receive a tablet form of the drug.
Is it possible to administer the drug intramuscularly?
How fast does the drug begin to act??
