Hyaluronic acid is a known pharmaceutical ingredient. However, there is no additional information currently available.
Juvederm Voluma XC is a drug made in Australia. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Hyaluronic acid is a complete analogue of Juvederm Voluma XC. It has the same composition, dosage and methods of use. Also Hyaluronic acid has a lower cost compared to Juvederm Voluma XC.
To buy Juvederm Voluma XC, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
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Side effects
Get emergency medical help if you have even mild symptoms:
Warnings
Interactions
Food interaction
Pregnancy
- Some medicines in this group may cause problems in pregnant women and have the potential to cause birth defects.
- The rate of spontaneous abortions was lower when exposure was only before pregnancy.
- Your doctor may test you for pregnancy in their office, or they may ask you to take a pregnancy test at home.
Overview
In solution, due to the presence in the molecule of segments with hydrophilic and hydrophobic properties, high molecular weight acid takes the spatial form of a swirling tape. Its chains, which are in continuous motion, in three-dimensional space form a loose additionally, which consists of domains (loops) of various sizes. The only molecule of HA, being in its structure polyanion, thanks to hydrogen bonds, it can connect and hold 200-500 Voluma molecules (in some sources - up to 1000 water Juvederm
The main functions in the body
Cellulose Hyaluronic Acid chondrocytes (the basic cellular structure of cartilage) is an essential element of articular cartilage. In the process of binding aggrecan monomers to HA with the assistance of a binding protein, the formation of negatively charged large aggregates that absorb water in the cartilage tissue is observed, whose properties ensure the elasticity of the cartilage, in other words, its resistance to compression. With age, the chain length (molecular weight) of the HA contained in the cartilage decreases, and its concentration, on the contrary, increases.
Hyaluronic acid inside the joint
In the composition of the synovial fluid, hyaluronic acid plays one of the main roles of the agent, which forms and retains the necessary viscosity of this substance, and along with lubricin is the main ingredient in biological lubrication.
In the skin, the qualities inherent in hyaluronic acid allow it to actively participate in the processes of tissue regeneration. For example, with excessive exposure to ultraviolet radiation on the skin and the formation of the inflammatory process "sunburn"In the cells of the dermis there is a suspension Juvederm the synthesis of HA and an increase in its decay rate.
Hyaluronic acid-rich young skin and older skin
The high content of hyaluronic acid in extracellular matrices allows it to influence the processes of tissue hydrodynamics, cell proliferation and migration, as well as to participate in interaction with a number of surface cell receptors, mainly with its primary CD44 receptor. It is the interaction of HA with the CD44 receptor that its participation in the process of occurrence can definitely be tumor formations.
There is evidence that at the same time that hyaluronic acid is linked to the CD44 receptor, the transduction of the inflammatory impulse of acid degradation products proceeds Voluma macrophage receptors and / or TLR2, TLR4 dendritic cells. HA and TLR (toll-like receptors) are congenital the immune system.
Biosynthesis
The synthesis of endogenous HA occurs due to the integrated membrane proteins, called hyaluronate synthetase. At present, three species have been found in vertebrate organisms. hyaluronate synthetase, namely HAS1, HAS2 and HAS3. These enzymes increase the HA molecule, stepwise attaching to the primary polysaccharide N-acetylglucosamine and glucuronic acid, while displacing the polymer into the intercellular space through the cell membrane.
Biodegradation
The process of degradation of HA is carried out using a family of enzymes called hyaluronidase. The human body has at least seven types of enzymes with hyaluronidase activity, some of which are suppressors of the formation of tumor formations.
The breakdown products of HA (low molecular weight hyaluronates and oligosaccharides) have pro-angiogenic properties. In addition, recent studies have shown that HA fragments, in contrast to the initial high molecular weight polysaccharide, can induce dendritic cells in tissue damage and rejection of transplanted skin integuments. macrophages inflammatory response.
Sources and methods of obtaining
