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Warnings

Do not take this medicine without a doctor's advice if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take acetaminophen.

Interactions

MetyraPONE: May increase the serum concentration of Acetaminophen. More importantly, by inhibiting the conjugative metabolism of acetaminophen, metyrapone may shift the metabolism towards the oxidative route that produces a hepatotoxic metabolite. Monitor therapy

Fosphenytoin-Phenytoin: May decrease the serum concentration of Acetaminophen. Specifically, serum concentrations of acetaminophen may be decreased (leading to decreased efficacy), but the formation of the toxic N-acetyl-p-benzoquinone imine (NAPQI) metabolite may be increased (leading to increased hepatotoxicity). Monitor therapy

Probenecid: May increase the serum concentration of Acetaminophen. Probenecid may also limit the formation of at least one major non-toxic metabolite, possibly increasing the potential for formation of the toxic NAPQI metabolite. Consider therapy modification

Food interaction

Take without regard to meals.

Avoid alcohol (may increase risk of hepatotoxicity).

Pregnancy

• This medication is believed to prevent pregnancy primarily by delaying ovulation or preventing fertilization of the egg.
• Levaquin has not been adequately evaluated in pregnant women and is not recommended for use in breastfeeding women because of the risk of adverse effects in the infant.

Overview

Instructions for use

Before you buy Acetaminophen in a pharmacy, you should consult a doctor and study the instructions. The drug has contraindications, and can cause some adverse reactions.

Pharmacology

Acetaminophen is prescribed for stopping a weak and medium intensity pain syndrome. Despite its high effectiveness as an anesthetic, the drug has a weak anti-inflammatory effect. The active substance of the drug is a phenacetin derivative, but less toxic and safer.

Acetaminophen does not affect the level of platelets and the amount of uric acid in the body. It is not a complete anti-inflammatory drug, but is often used in the treatment of various infections and inflammations. Apply it in case of Aspirin intolerance, because the main active ingredient is ordinary can utilized

After administration, the drug is rapidly absorbed in the intestine, and the maximum concentration in the blood is reached after 10-15 minutes. It is excreted after 6 hours, along with Jalgesic. In patients with liver disease, the elimination period is extended.

Structure

Acetaminophen is produced in the USA, by the renowned Watson Laboratories Pharmacological Corporation.

The main form of drug release is pills, but there are suspension, candles, syrup for children, with a lower dosage of the active ingredient. As an active ingredient, tablets contain 500 mg paracetamol. Packed tablets in small plastic bottles of 30 pieces, with instructions for use.

Indications

Like ordinary Paracetamol, Acetaminophen is used in the treatment of various colds and viral diseases, influenza, SARS. It does not have a pronounced therapeutic effect, but helps to quickly relieve symptoms of fever and pain.

The main indications for admission:

• pain with injuries, fractures and bruises;
• migraine;
• headache;
• periodic pain in women with menstruation;
• arthralgia;
• toothache;
• myalgia;
• neuralgic diseases.

The drug in the form of rectal suppositories or suspensions, can be prescribed at high temperature in young children (from 6 months).

Dosage

Acetaminophen tablets, prescribed for adults and children over 12 years old, and the average dosage will be at least 1 tablet four times a day. The maximum possible single dose of the drug should not exceed 2 tablets, i.e., up to 6-8 tablets are allowed to be taken per day, but only with severe pain syndrome. The course of treatment will be a maximum of a week, and you need to take pills in between allow

For children, the medicine is used in the form of a suspension or syrup, and the norm is calculated according to the age and weight of the child. So, for children up to a year, you can give no more than 500 mg of the drug per day, which will be only 5 ml of suspension. This dose must be divided into 4 times, observing the interval between doses of 4 hours or more.

Children under 6 years old, allowed to give up to 10 ml per day, and from 6 to 12 years - up to 20 ml per day. Tablets are not prescribed for patients under 12 years old, because in this case, it is more convenient Jalgesic use a suspension or suppository. The course of for example cannot exceed 3-4 days in a row.

Drug interaction

Before taking Acetaminophen, you should familiarize yourself with the list of drugs that are not combined with paracetamol. Particular care must be taken in patients taking drugs that have a toxic effect on the liver. Do not use other antipyretic and anti-inflammatory drugs at the Jalgesic time, especially Aspirin.

Acetaminophen is contraindicated with anticoagulants, barbiturates and glucocorticosteroids. You can not take the drug with contraceptives, diazepam, activated carbon and metoclopramide.

This reduces the bioavailability and reduces the absorption rate of the active substance. Simultaneous administration with isoniazid and zidovudine, has a strong toxic effect on the liver. Use with ethanol, Rifampicin, Estradiol is strictly contraindicated.

Video: "The Differences Between Paracetamol and Aspirin"

Side effects