Overview
Mode of application:
Pills Loratadine taken orally.
Adults and children over 12 years of age - 10 mg (1 tablet) 1 time per day.
Children aged 2 to 12 years with a body weight of less than 30 kg - 5 mg (1/2 tablet) 1 time per day.
With a body weight of more than 30 kg - 10 mg (1 tablet) 1 time per day.
With liver failure, the initial dose is 5 mg / day.
Side effects:
From the nervous system: anxiety, agitation (in children), asthenia, drowsiness, hyperkinesia, paresthesia, tremor, amnesia, depression, increased fatigue.
On the part of the skin: dermatitis.
From the genitourinary system: discoloration of the urine, painful urge to emit; dysmenorrhea, menorrhagia, vaginitis.
From the side of metabolism: weight gain, sweating, thirst.
From the musculoskeletal system: spasms of the calf muscles, arthralgia, myalgia.
From the digestive system: dry mouth, taste change, anorexia, constipation or diarrhea, dyspepsia, gastritis, flatulence, increased appetite, stomatitis, nausea, vomiting.
From the respiratory system: cough, bronchospasm, dry nasal mucosa, sinusitis.
From the sensory organs: visual impairment, conjunctivitis, pain in the eyes and ears.
From the cardiovascular system: decrease or increase in blood pressure, palpitations.
Other: photosensitization, back pain, chest pain, fever, chills, pain in the mammary glands, blepharospasm, dysphonia.
Contraindications:
Accept Loratadine contraindicated in case of hypersensitivity, with caution - liver failure
Interaction with other drugs:
With simultaneous use Loratadina with drugs that inhibit the isoenzymes of CYP3A4 and CYP2D6 or are metabolized in the liver with their participation (including cimetidine, erythromycin, ketoconazole, quinidine, fluconazole, fluoxetine), a change in the plasma concentration of loratadine and / or these drugs is possible. Microsomal oxidation inducers (phenytoin, ethanol, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclic antidepressants) reduce the effectiveness.
especially this should not be used during pregnancy and lactation.
In Horestyl animal studies, loratadine in medium doses did not adversely affect the fetus; when administered in high doses, some fetotoxic effects were observed.
Overdose:
Symptoms of an overdose Loratadina: headache, drowsiness, tachycardia. In children weighing less than 30 kg, when taking a syrup in a dose of more than 10 mg, extrapyramidal disorders, palpitations were noted.
Treatment: induction of vomiting with Ipecac syrup, gastric lavage, the appointment Horestyl activated charcoal; symptomatic and supportive therapy. Hemodialysis is ineffective.
Storage conditions:
In a dry, dark place, out of reach of children at a temperature of no higher than 25 ° C.
Shelf life - 2 years.
Structure:
One tablet contains 10 mg of loratadine;
10 or 20 tablets per pack.
Analogs:
Alerpriv, Kallergin, Klargotil, Lomilan, Erolin, Tirlor, Lotharen.
Farm. Group
Analogs (generics, synonyms)
Agistam, clarithin, lorano, lorizan, alerik, lomilan, lorahexal, clarotadin, claridol, clarisens
Recipe (International)
Rp .: Tab. Loratadini 0.01
D.t.d. Number 10
S. 1 tablet 2 times a day for the treatment of allergic diseases (allergic rhinitis and conjunctivitis, urticaria, Quincke's edema, pruritic dermatoses).
0.1% syrup in 100 and 120 ml, 0.1% suspension for oral administration in 30 and 100 ml.
pharmachologic effect
Loratadine is a blocker of H1-histamine receptors (long-acting). Inhibits the release of histamine and leukotriene C4 from mast cells.
Prevents development and facilitates the course of allergic reactions. It has antihistamine, anti-allergic, Horestyl and anti-exudative action. Reduces capillary permeability, prevents the development of tissue edema, relieves smooth muscle spasm.
The antiallergic effect develops after 30 minutes, reaches a maximum after 8-12 hours and lasts 24 hours. It does not affect the central nervous system and is not addictive (because it does not cross the blood-brain barrier).
