Econazole topical may also be used for purposes not listed in this medication guide.
Gyno-Pevaryl Once is a drug made in United Kingdom. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Econazole is a complete analogue of Gyno-Pevaryl Once. It has the same composition, dosage and methods of use. Also Econazole has a lower cost compared to Gyno-Pevaryl Once.
To buy Gyno-Pevaryl Once, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Tell your doctor about any unusual or bothersome side effect. oozing, or unusual or severe blistering, swelling, peeling, stinging, irritation, redness, swelling,
Warnings
Tell your doctor if you take a blood thinner such as warfarin (Coumadin, Jantoven).
If you are pregnant, your doctor will decide if it is safe for you to use econazole topical. Econazole topical is sometimes used during the first trimester of pregnancy. It is not known whether the medicine will harm an unborn baby during the second or third trimesters of pregnancy.
Interactions
Vitamin K Antagonists (eg, warfarin): Econazole may increase the serum concentration of Vitamin K Antagonists. Monitor therapy
Food interaction
Pregnancy
- If a pregnancy does not occur then over the next week the levels will fall and menstruation will start.
- You should not take this medicine while you are pregnant.
- Therefore, caution should be exercised when the drug is used during pregnancy.
Overview
The fungus has long been considered an intractable disease due to its special structure. It is very difficult to act on a cell so reliably protected. Imidazole, as well as econazole sodium, slows down and prevents the synthesis of sterol-14-demethylase and isofremed cytochrome P450. In this case, ergosterol production is disrupted, and the latter is just responsible for the permeability of the fungal membrane.
In this case, the accumulation of 14-a-methylsterols occurs, which leads to a violation of the functionality of membrane proteins. In such a long way, accumulation of too high doses of hydrogen Gyno-Pevaryl inside the cell is achieved, which eventually damages the membrane and causes cell necrosis. The effectiveness of econazole in relation to dermatophytes and yeast-like fungi is very high - already on the 3rd day of application of the cream, death of fungi is observed.
Pharmacokinetics
The medicine penetrates the upper layer of the skin - the horn, and the nail plate. It is once in the stratum corneum, as well as in the dermis. The substance is fat-soluble, therefore, penetrates into the tissue quite easily.
- Less than 1% of the used dose is excreted by the intestines and kidneys.
- Carcinogenicity and mutagenicity of the drug were not evaluated.
Indications
Econazole is used in the treatment of all skin ailments caused by the corresponding pathogen - dermatophytes, yeast-like fungi and mold:
- dermatomycosis of the skin, including lesions of the scalp. Used, and very effective, and in the case when dermatitis is complicated by infection with gram-positive bacteria;
- erythrasma;
- cutaneous candidiasis - an infection caused by yeast-like fungi;
- multi-colored lichen;
- onychomycosis - damage to the nails;
- thrush - vulvaginal candidiasis;
- colpitis - inflammation of the vaginal mucosa;
- fungal balanitis.
Instructions for use
Recommendations for use differ for different forms of release and different applications. Any dosage form is accompanied by detailed instructions.
For adults
Econazole is used only on damaged areas. The drug does not irritate healthy skin, but it does not have any positive effect. The cream is applied to the affected area with a thin layer and rubbed lightly. Aerosol is sprayed and also rubbed.
- With dermatomycosis, treatment of the feet, torso, legs is performed 1 once per day.
- With multi-colored lichen, it is also sufficient to lubricate the spots 1 time per day.
- With skin candidiasis, the cream is applied 2 per day.
To consolidate the result and prevent relapse, the cream is used for at least 2 weeks for candidiasis and dermatomycosis of the legs and trunk and at least 1 month for damaged feet. If during this Gyno-Pevaryl a positive effect is not achieved, you need to review the diagnosis.
For the treatment of colpitis and thrush, candles and cream are used:
- suppositories are administered deep to the posterior wall of the vagina, usually at night. Suppositories with a dosage of 150 g are used for 3 days, with a dosage of 50 mg - up to 2 weeks;
- a cream applicator is inserted deep into the vagina. The course is 2 weeks .
With insufficient positive effect, treatment can be extended for 3 days. To consolidate the result, it is recommended to repeat the course after 10 days. The drug can be used during menstruation.
In the treatment of mycosis of the auditory canal, 1-2 drops of a solution of the substance are instilled into the ear or a piece of gauze is moistened in it and placed in the ear canal.
Children and newborns
For children under 18 years of age, the drug is not prescribed. No data on safety or risks of use in this age group.
During pregnancy and lactation
Pregnant women should not use potent antimycotic drugs. In the first semester, econazole can be prescribed for health reasons. In the following two use is permissible only in case of emergency.
