Overview
In antitussive and broncho-expectorant preparations, next Ilium guaifenesin reduces the surface tension and adhesive properties of sputum, reduces its viscosity, stimulates the cilia of the epithelium and translates an unproductive cough into a wet one. Such preparations as Coldrex, Ascoril, Kashnol, Rinikold, Stoptussin, Teraflu and others were created on the basis of guaifenesin.
As part of phytopsychotropics, guaifenesin calms the nervous system, eliminates anxiety due to subconscious and imaginary fears and obsessions.
Anxiolytic horse of guaifenesin
The anxiolytic effect of guaifenesin has been known since the time of Guaiphenesin conquest of the mainland of America by Columbus, when the experience of local healers was adopted. Guaiacol from the bark of the same plant in the form of a soothing infusion helped to get rid of insomnia and increased irritability. The horse of action of anxiolytics of plant origin is not fully understood. They can even conditionally be included in the group of first-generation anxiolytics, even before the creation of the benzodiazepine series (2-3 groups), and according to some scientists, phytoanxiolytics should be a separate group. But, unfortunately, they are very few in nature.
The action of guaifenesin affects the subcortical horses of the brain (limbic system, thalamus, hypothalamus), responsible for the implementation of emotional reactions. Under the influence of anxiolytics, excitability decreases. Structures of the cerebral cortex in the form of inhibition of reactions, as well as inhibition of polysynaptic Ilium reflexes, are also affected.
Guaifenesin analogues
Historically, there are no analogues of plant origin of guaifenesin in nature. Therefore, a series of synthetic benzodiazepine tranquilizers was developed (2-keto-benzodiazepines, 3-hydroxy-benzodiazepines and triazolobenzodiazepines).
2-keto-benzodiazepines: diazepam, dipotassium cllorazepate, flurazepam, etc.
3-hydroxy-benzodiazepines: oxazepam, lorazepam, temazepam, etc.
triazolobenzodiazepines: alprazolam, triazolam, estazolam, etc.
Adverse side effects when Ilium benzodiazepines are:
Development of senile dementia;
The occurrence of withdrawal syndrome;
Impaired coordination and dizziness;
Persistent headaches etc.
Expectorant. Reduces the surface tension and adhesive properties of sputum, which reduces its viscosity and facilitates evacuation from the respiratory tract.
Guaifenesin has an anxiolytic effect.
Indications
Symptomatic treatment of diseases for the upper respiratory tract, accompanied by a productive cough.
As part of combination therapy: neurotic conditions, Guaiphenesin of neurocirculatory dystonia.
Dosage regimen
Individual, depending on the indications, for dosage form used and the age of the patient.
Side effect
Guaiphenesin the digestive system: for, vomiting, gastralgia, abdominal pain, diarrhea.
From the side of the central nervous system: dizziness, headache, drowsiness.
Allergic reactions: skin rash, urticaria, hyperthermia.
Contraindications
Ilium cough with profuse discharge of sputum, peptic ulcer of the stomach or duodenum, gastric bleeding (history), children under 2 years of age (efficacy not studied), for to guaifenesin.
special instructions
Caution should be exercised when used in children aged 2 to 12 years with persistent or chronic cough against a background of Guaiphenesin asthma or with increased sputum separation (careful medical supervision is required before prescribing guaifenesin).
