Overview
The dose is set individually depending on the severity of the infection, age, body weight and kidney function of the patient.
For adults and children over 12 years of age, a single dose on average is 250 mg, the frequency of administration Grefidim 2 times / day.
In severe infections of the upper and lower respiratory tract, 500 mg is prescribed 2 times / day; for infections of mild to moderate severity - 250 mg 2 times / day.
In case of urinary tract infections, 125 mg 2 times / day are prescribed, with pyelonephritis - 250 mg 2 times / day.
For infections of the skin and soft tissues - 250 - 500 mg 2 times / day.
In the treatment of uncomplicated gonorrhea, 1 g is prescribed once.
In Lyme disease, adults and children over 12 years old - 500 mg 2 times / day for 20
The maximum daily dose for adults - 6 g.
The average dose for children with most infections is 1/2 tab. (125 mg) 2 times / day. In severe infections or otitis media in children aged 2 years and older, the average dose is 125 mg - 250 mg 2 times / day.
The maximum daily dose for children is 500 mg.
Dosage regimen for patients with impaired renal function, for those on dialysis, and older people.
When using the drug in a dose not exceeding 1 g of cefuroxime axetil per day, dose adjustment is not required.
The average duration of treatment is 7 days (5-10 days). For the treatment of pharyngotonsillitis caused by Streptococcus pyogenes, the duration of treatment is 10 days. Duration of therapy for early manifestations of the disease.
The drug should be taken after a meal. The tablets are swallowed whole without chewing.
Side effect
From the digestive system: diarrhea, nausea, vomiting, constipation, flatulence, cramping and abdominal pain, ulceration of the oral mucosa, anorexia, thirst, glossitis, oral candidiasis, rarely - pseudomembranous enterocolitis.
From the hepatobiliary system: in isolated cases - increased activity of hepatic transaminases and bilirubin in blood plasma, cholestatic jaundice, hepatitis.
Allergic reactions: rash, itching, urticaria, eosinophilia, Quincke's edema, rarely erythema multiforme exudative (including Stevens-Johnson syndrome), bronchospasm, toxic epidermal necrolysis, serum sickness, drug fever, in rare cases, anaphylaxis.
On the part of the blood system and lymphatic system: rarely - a decrease in the level and hematocrit, transient eosinophilia, transient neutropenia and leukopenia, thrombocytopenia; very rarely - aplastic and hemolytic anemia, agranulocytosis, hypoprothrombinemia, prolongation of prothrombin time (with prolonged use in high doses).
On the part of the kidneys and urinary tract: itching in the perineum, vaginitis, dysuria, impaired renal function, increased levels of creatinine and / or urea nitrogen in the blood serum, decreased creatinine clearance, especially in patients with renal failure; rarely - acute interstitial nephritis.
From the side of the central nervous system: headache, dizziness, drowsiness; very rarely - agitation, irritability, confusion, convulsions (with renal failure).
From the ENT organs: very rarely - open page to Grefidim hearing loss in children after treatment of meningitis.
Other: prolonged use of the drug may lead to the development of secondary superinfection caused by resistant microorganisms such as Candida, Enterococci and Clostridium difficile; chest pain, shortness of breath, dysbiosis.
Laboratory indicators: pseudo-positive reaction Qum ^ £ Which may affect the results of blood compatibility tests; false positive glucosuric test.
