Orphenadrine may also be used for purposes not listed in this medication guide.
Glogesic is a drug made in Pakistan. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Orphenadrine is a complete analogue of Glogesic. It has the same composition, dosage and methods of use. Also Orphenadrine has a lower cost compared to Glogesic.
To buy Glogesic, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
No other new adverse reactions were identified. Blurred vision eye pain sores, ulcers, or white spots on lips or in mouth muscle weakness fast, pounding irregular heartbeat or pulse Dizziness or lightheadedness fainting chills
Warnings
It is not known whether orphenadrine passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.
Interactions
Pramlintide: May enhance the anticholinergic effect of Anticholinergic Agents. These effects are specific to the GI tract. Consider therapy modification
Glycopyrronium (Topical): May enhance the anticholinergic effect of Anticholinergic Agents. Avoid combination
Botulinum Toxin-Containing Products: Muscle Relaxants (Centrally Acting) may enhance the adverse/toxic effect of Botulinum Toxin-Containing Products. Specifically, the risk for increased muscle weakness may be enhanced. Monitor therapy
Food interaction
Take without regard to meals. Avoid alcohol.
Pregnancy
- The potential increased risk should be considered in the context of the benefits of treating depression in pregnancy.
- To notify their healthcare provider immediately if a pregnancy occurs or is suspected.
Overview
Other drugs may interact with orphenadrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all the medicines you are using now and about any medicines that Glogesic start or stop using.
Your pharmacist can provide more information about orphenadrine.
a drug that reduces muscle cramps; used to treat all types of parkinsonism. It is administered orally or by injection; possible side effects include dry mouth, blurred vision, and difficulty urinating. Trade Names: Disipal (Disipal), Norflex (Norflex).
Watch value Orphenadrine (orphenadrine) in other dictionaries
Orphenadrine - (orphenadrine) - a medicinal substance that reduces muscle cramps; used to treat all types of parkinsonism. It is administered orally or by injection; possible.
Psychological Encyclopedia
N,N-dimethyl-2 - [(2-methylphenyl) - phenyl-methoxy] -ethanamine
IUPAC name Cas number
83-98-7 ATC code
PubChem
4601 Drugbank
APRD00097 Chemical formula <<>> Molecular weight 269.381 g / mol Glogesic Bioavailability 90% Metabolism Hepatic demethylation Elimination half-life 13-20 hours [1] Excretion Renal and biliary Pregnancyancy category <<>> Legal status <<>> Routes of administration Oral, intravenous, intramuscular
Orphenadrine (sold under the brand names Norflex ®, Mephenamin ®, Disipal ®, Banflex ®, Flexon ®, Biorphen ®, Brocasipal ®, and others) is an antihistamine drug used to treat pain, muscle spasms and other symptoms of injury, and other problems. It is also used for treating some aspects of Parkinson's Disease.
In addition to muscle-relaxed and antihistaminergic effects, orphenadrine has significant antispasmodic, direct analgesic, and weak to moderate local anaesthetic actions. It also produces drowsiness and can have mild sedative and anxiolytic effects.
History edit
This drug was first synthesized in the late 1940s in Europe and patented in the United States by Parke-Davis in July 1951. Currently, orphenadrine prepared are made in the United States and Canada by Parke-Davis and other companies including 3M.
Chemistry edit
Orphenadrine is a methylated derivative of diphenhydramine (Benadryl, Sominex, Nytol, etc.), and thus belongs to the ethanolamine family of antihistamines. It is produced by reacting dimethylaminoethanol with 2-methylbenzhydryl chloride. The 2-methylbenzhydryl chloride can be formed via a Grignard reaction. The free base has a molecular weight of 269.38 and an empirical formula of CeighteenH23NO The molecular weight of orphenadrine hydrochloride is 305.85, and 461.50 for the citrate.
Pharmacology Edit
Orphenadrine is an anticholinergic and an NMDA receptor antagonist [1]. The action of orphenadrine against muscle spasm and the pain produced by it, pain produced independent of muscle spasm, neuropathic pain, and the extrapyramidal effects of Parkinson's Disease and treatments with, Glogesic the result of orphenadrine's moderate anticholinergic activity, which is about 58% the antimuscarinic strength of atropine.
Orphenadrine works by reducing muscle spasm and pain of varying etiologies and types, acute pain of injury and other causes as well as chronic and recurring acute pain syndromes producing nociceptive and / or neuropathic pain. It can be used as the main analgesic / muscle relaxed in cases of, for example, sports injuries, or as an atypical (adjuvant) analgesic and / or adjunct to typical analgesics such as opioids and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and for reduction of some histamine-related side effects of opioids, especially codeine and its semi-synthetic derivatives.
