Over-the-counter (OTC) omeprazole is used to help control heartburn that occurs 2 or more days per week. The OTC brand of omeprazole must be taken as a course on a regular basis for 14 days in a row.
Glaveral is a drug made in Malta. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Omeprazole is a complete analogue of Glaveral. It has the same composition, dosage and methods of use. Also Omeprazole has a lower cost compared to Glaveral.
To buy Glaveral, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Tell your doctor right away of any new symptoms that occur during or after treatment. inflammation within the kidneys pancreatitis liver damage
Warnings
Ask a doctor or pharmacist if it is safe for you to use omeprazole if you have other medical conditions, especially:
- trouble or pain with swallowing;
- bloody or black stools, vomit that looks like blood or coffee grounds;
- heartburn that has lasted for over 3 months;
- frequent chest pain, heartburn with wheezing;
- unexplained weight loss;
- nausea or vomiting, stomach pain;
- liver disease;
- low levels of magnesium in your blood; or
- osteoporosis or low bone mineral density (osteopenia).
You may be more likely to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.
You should not use omeprazole if you are allergic to it, or if:
- you are also allergic to medicines like omeprazole, such as esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others; or
- you also take HIV medication that contains rilpivirine (such as Complera, Edurant, Odefsey, Juluca).
Interactions
Dasatinib: Proton Pump Inhibitors may decrease the serum concentration of Dasatinib. Management: Antacids (taken 2 hours before or after dasatinib administration) can be used in place of the proton pump inhibitor if some acid-reducing therapy is needed. Avoid combination
CYP2C19 Inducers (Moderate): May decrease the serum concentration of CYP2C19 Substrates (High risk with Inducers). Monitor therapy
Enzalutamide: May decrease the serum concentration of CYP2C19 Substrates (High risk with Inducers). Conversely, concentrations of active metabolites may be increased for those drugs activated by CYP2C19. Management: Concurrent use of enzalutamide with CYP2C19 substrates that have a narrow therapeutic index should be avoided. Use of enzalutamide and any other CYP2C19 substrate should be performed with caution and close monitoring. Consider therapy modification
Food interaction
Take 30-60 minutes before meals.
Avoid alcohol.
Pregnancy
- These medications are not recommended for women who are or would like to become pregnant.
- If you or your partner become pregnant while taking this medication, contact your doctor immediately.
- There is little experience with its use during human pregnancy.
Overview
Comparison of omeprazole with other proton pump blockers
There is currently no consensus among gastroenterologists regarding the comparative efficacy of specific types of Glaveral pump inhibitors. Some of them argue that, despite the differences that exist between PPIs, today there is no rigorous evidence to judge the effectiveness of a PPI visibly for an ordinary patient in relation to others (Vasiliev Yu.V. et al.). Also, a number of gastroenterologists believe that when HP is eradicated, the type of PPI used in combination with antibiotics does https://zentherapycenter.com/let-i/iron-plus.php matter (Nikonov E.K., Alekseenko S.A.). Others argue that, for example, esomeprazole is fundamentally different from the other four PPIs: omeprazole, pantoprazole, lansoprazole and rabeprazole (Lapina T.L., Demyanenko D., etc.). Still others write that the antisecretory effect of Losec MAPS (omeprazole MAPS) and pariete (rabeprazole) according to the daily pH-metric data significantly exceeds nexium (esomeprazole) (Ivashkin V.T. et al.).
According to D. Bordin, the effectiveness of all PPIs with long-term treatment of Glaveral is close. In the early stages of therapy, lansoprazole has some advantages in the rate of onset of the effect, which potentially increases the patient's adherence to treatment. If it is necessary to take several drugs for the simultaneous treatment of various diseases, pantoprazole is most safe.
The differences in the antisecretory effect of lansoprazole and omeprazole are explained by the fact that T½ of lansoprazole and omeprazole this 1.3 and 0.7 hours, respectively. The bioavailability of lansoprazole is more than 85% when taking the first dose and remains constant with repeated doses. When taking the first dose of omeprazole, the bioavailability is only 35%, with repeated doses it rises to 60% by the third or fifth day. In addition, the metabolism of omeprazole is carried out in the liver mainly by the isoform CYP2C19 of the cytochrome P450 system, medicine lansoprazole by the additional isoenzyme CYP3A4. As a result of this, when taking omeprazole, a more pronounced variability of the antisecretory effect is observed depending on the heterogeneity of the CYP2C19 gene (S. Alekseenko).
In countries - former republics of the USSR, omeprazole is widely represented by generics. Prices for generic omeprazole are much lower than prices for original drugs, such as elk, MAPC, pariet or nexium, which is important for the patient and often determines the choice of the drug based on financial capabilities, especially for long-term use. Due to possible differences in the quality of medicines, an objective assessment of their clinical effectiveness is often necessary. At present, 24-hour monitoring of intragastric pH is an objective and affordable method of testing antisecretory drugs in clinical practice (S. Alekseenko).
Comparison of various omeprazole preparations
Night acid breakthrough
Omeprazole, like other proton pump inhibitors, is characterized by the phenomenon of “night acid breakthrough” - a phenomenon in which, at night, regardless of the dose of the drug, a prolonged, over an hour, increase in acidity in the stomach occurs (pH Note. *) Letter from the Ministry of Health of Russia 08/15/2014, No. 20-2 / 10 / 2-6169. On amendments to the instructions for use of medicinal products registered in the Russian Federation for medical use containing omeprazole as an active substance.
Omeprazole has contraindications, side effects and features of use, consultation with a specialist is necessary.
Prices in online pharmacies:
Omeprazole is an antiulcer drug that is a hydrogen pump blocker - N + / K + -ATPase, reduces the aggressiveness of gastric juice, providing a decrease in acidity. The drug refers to prodrugs, helps to suppress the secretion of hydrochloric acid in any nature of the irritant.
Release form and composition
Omeprazole is available in the form of gelatin opaque, hard capsules containing white or light beige, spherical pellets. In each capsule, a dosage of 20 or 10 mg of the active ingredient is omeprazole, other components are: silicon dioxide colloidal, hypromellose, starch, hyporolose, magnesium carbonate, sucrose, methacrylic acid and ethyl acrylate copolymer, talc, polysorbate-80, sodium hydrogen phosphate, titanium dioxide. Omeprazole is realized:
- 10 capsules in packs enclosed in 2-3 pieces in packs of cardboard;
- 30 or 40 capsules in polymer jars enclosed in cardboard boxes.
Indications for use
According to the instructions for Omeprazole, the medication is indicated for use in:
