Overview
Application restrictions
A history of gastric and duodenal ulcer, arterial hypertension, hearing loss, vestibular apparatus pathology, advanced age, suspected infectious disease (for iv use).
Pregnancy and lactation
Contraindicated in the III trimester of pregnancy, in the I and II trimester - with caution.
Breastfeeding should be discontinued during treatment.
Side effects of the substance ibuprofen
From the digestive tract: nausea, vomiting, NSAID gastropathy (loss of appetite, pain and discomfort in the epigastric region, abdominal pain), irritation, dry mucous membrane or pain in the oral cavity, ulceration of the mucous membrane of the gums, aphthous stomatitis, pancreatitis, constipation / diarrhea, flatulence, treated, possibly - erosive and ulcerative lesions and bleeding from the digestive tract, impaired liver function.
From the nervous system and sensory organs: headache, drowsiness, anxiety, nervousness, irritability, psychomotor agitation, confusion, hallucinations, aseptic meningitis (more often in patients with autoimmune diseases), hearing impairment, tinnitus, reversible toxic amblyopia, blurred vision or double vision, dryness and eye irritationedema of the conjunctiva and eyelids (allergic genesis), scotoma.
From the cardiovascular system and blood (hematopoiesis, hemostasis): heart failure, tachycardia, increased blood pressure, eosinophilia, anemia, including hemolytic, thrombocytopenic purpura, agranulocytosis, leukopenia.
From the respiratory system: shortness of breath, bronchospasm.
From the genitourinary system: edema syndrome, impaired renal function, acute renal failure, polyuria, cystitis.
Allergic reactions: skin rash (erythematous, urtikarnaya), skin itching, urticaria, allergic rhinitis, allergic nephritis, Quincke's edema, anaphylactic reactions, including anaphylactic shock, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis.
Other: sweating, fever.
With a / in the introduction
From the blood system: clotting disorders leading to bleeding and hemorrhage, including intestinal and intracranial, respiratory disorders and pulmonary hemorrhages.
From the glare tract: bowel obstruction and perforation.
From the side of the kidneys: decrease in the volume of urine formed, the presence of blood in the urine.
https://zentherapycenter.com/let-m/maltem.php, glare is evidence for approximately 1000 preterm infants found in the ibuprofen literature and obtained in clinical studies of ibuprofen with iv administration. The causes of adverse events observed in premature infants are difficult to assess, because they can be associated with both the hemodynamic effects of the open ductus arteriosus and the direct effects of ibuprofen.
The adverse events described below are:
From the hematopoietic and lymphatic system: > 1/10 - thrombocytopenia, neutropenia.
From the nervous system: > 1/100, 1/10 - bronchopulmonary dysplasia; > 1/100, 1/1000, 1/100, 1/1000, 1/100, 1/1000, 1/10 - an increase in the concentration of creatinine in the blood, a decrease in the concentration of sodium in the blood.
For external use
Irritation of the skin in the form of redness, swelling, rashes or itching; with prolonged use - systemic adverse reactions.
Interaction
The simultaneous use of two or more NSAIDs should be avoided due to an increased risk of side effects. With the simultaneous use of ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency element patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after starting ibuprofen). When used with thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding increases simultaneously. Ibuprofen enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics.
