Glimepiride is an oral diabetes medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. glimepiride is not for treating type 1 diabetes.
Getryl is a drug made in Pakistan, Philippines. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Glimepiride is a complete analogue of Getryl. It has the same composition, dosage and methods of use. Also Glimepiride has a lower cost compared to Getryl.
To buy Getryl, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Check with your physician for additional information about side effects. feeling very thirsty liver function feeling very hungry even though you’re eating aspirin sweating lightheadedness or dizziness confusion, including delirium sulfadiazine
Warnings
Glimepiride is not approved for use by anyone younger than 18 years old.
Follow your doctor's instructions about using this medicine if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester.
Interactions
Alpha-Lipoic Acid: May enhance the hypoglycemic effect of Antidiabetic Agents. Monitor therapy
CYP2C9 Inhibitors (Moderate): May decrease the metabolism of CYP2C9 Substrates (High risk with Inhibitors). Monitor therapy
Mitiglinide: May enhance the adverse/toxic effect of Sulfonylureas. Avoid combination
Food interaction
Even though food reduces product absorption, the manufacturer recommends taking the product with the first meal of the day.
Avoid alcohol.
Pregnancy
- Before prescription, a thorough case history should be taken and a thorough gynaecological examination is recommended to exclude pregnancy.
- Under no circumstances should a woman fall pregnant while on this medication.
Overview
Attention! This medication may be especially undesirable to interact with alcohol! More details.
Indications for use
Possible analogues (substitutes)
Active substance, group
Dosage form
Contraindications
Hypersensitivity (including to other sulfanilamides), type 1 diabetes mellitus, diabetic ketoacidosis, diabetic precoma and coma, hyperosmolar coma, severe hepatic and renal failure (including patients on hemodialysis), pregnancy, period lactation.
Getryl to use: dosage and course of treatment
Inside, without chewing, with a sufficient amount of liquid, before a hearty breakfast, in an initial dose of 1 mg 1 time per day. If necessary, the daily dose can be increased gradually (by 1 Getryl every 1-2 weeks) to a maximum of 6 mg.
Treatment: long, controlled by blood and urine glucose.
pharmachologic effect
Hypoglycemic agent, a sulfonylurea derivative of the third generation. It stimulates beta cells of pancreatic islets, promoting mobilization and increased release of endogenous insulin, increases the number of insulin-sensitive receptors in target cells, and inhibits gluconeogenesis. Improves postprandial insulin / C-peptide response, reduces hyperglycemia without increasing fasting insulin / C-peptide concentration. Extrapancreatic effects are an increase in the sensitivity of peripheral tissues to insulin. Reduces the risk of retino- neuro- and nephropathy. With a combined prescription, it reduces the dose of insulin in obese patients by 38%. The maximum effect is achieved after 2-3 hours, the hypoglycemic effect lasts longer than 24 hours.
Side effects
Hypoglycemia, Getryl vision (due to hypoglycemia), dizziness, headaches, asthenia, nausea, vomiting, feeling of fullness in the epigastrium, abdominal pain, diarrhea, increased activity of hepatic transaminases, cholestasis, jaundice, hyponatremia, suppression of bone marrow hematopoiesis ( leukopenia, agranulocytosis, aplastic anemia, pancytopenia), hemolytic anemia, allergic reactions (vasculitis, less commonly hepatitis).
Rarely - shortness of breath, decreased blood pressure, photosensitivity, late cutaneous porphyria.
special instructions
Regular monitoring of blood and urine glucose.
With insufficient effect or a decrease in action with prolonged monotherapy (secondary resistance), a Getryl with insulin is recommended.
Major surgical interventions and injuries, extensive burns, infectious diseases with febrile syndrome may require discontinuation of oral glypoglycemic drugs and the administration of insulin.
Patients should be warned about the increased risk of hypoglycemia in cases of ethanol intake (including the development of disulfiram-like reactions: abdominal pain, nausea, vomiting, headache), NSAIDs, and starvation.
A dose adjustment is necessary for physical and emotional overstrain, a change in diet.
Clinical manifestations of hypoglycemia can be masked when taking beta-blockers, clonidine, reserpine, guanethidine.
During the treatment period, caution must be exercised when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.
