Clomipramine is a tricyclic antidepressant. It affects chemicals in the brain that may be unbalanced.
GenRX Clomipramine is a drug made in Australia. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Clomipramine is a complete analogue of GenRX Clomipramine. It has the same composition, dosage and methods of use. Also Clomipramine has a lower cost compared to GenRX Clomipramine.
To buy GenRX Clomipramine, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. confusion, extreme fear, thoughts of hurting yourself; tiredness, memory problems, trouble concentrating; flushing, enlarged or painful breasts, increased sweating, drowsiness, feeling anxious, restless, dizzy, drowsy, or tired;
Warnings
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Clomipramine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using this medicine.
You should not take this medicine if you are allergic to clomipramine or to similar antidepressants (amitriptyline, amoxapine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, or trimipramine).
Interactions
Guanethidine: Tricyclic Antidepressants may diminish the therapeutic effect of Guanethidine. Monitor therapy
Nicergoline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Iomeprol: Agents With Seizure Threshold Lowering Potential may enhance the adverse/toxic effect of Iomeprol. Specifically, the risk for seizures may be increased. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iomeprol. Wait at least 24 hours after the procedure to resume such agents. In nonelective procedures, consider use of prophylactic anticonvulsants. Consider therapy modification
Food interaction
Grapefruit and grapefruit juice should be avoided throughout treatment, grapefruit can modify serum levels of clomipramine and its metabolite desmethyl-clomipramine.
Take with food to reduce irritation.
Avoid alcohol.
Pregnancy
- The background risk of major birth defects and miscarriage for the indicated population are unknown.
- Pregnancy category D after 30 weeks of pregnancy.
Overview
Structure
1 tablet contains:
clomipramine hydrochloride - 25 mg;
microcrystalline cellulose - 37.75 mg, lactose monohydrate - 9.05 mg, croscarmellose sodium - 1.875 mg, magnesium stearate - 1.125 mg, colloidal silicon dioxide - 0.2 mg;
hydroxypropyl methylcellulose (hypromellose) 2910 - 1.6 mg, polyethylene glycol (macrogol) 3350 - 0.4 mg, titanium dioxide (E 171) - 0.97 mg, yellow iron oxide - 0.03 mg.
Description of the dosage form
Round, biconvex tablets, film-coated, pale yellow. “25” is engraved on one side, the other side is smooth.
Pharmacodynamics
Clomipramine is a tricyclic antidepressant from the group of non-selective monoamine neuronal uptake inhibitors. It has a pronounced timoanaleptic effect, refers to antidepressants of a balanced action (a combination of psychostimulating and anxiolytic, sedative). The mechanism of the antidepressant action of clomipramine is associated with the GenRX to inhibit the reuptake of norepinephrine and serotonin by the corresponding neurons (the reuptake of serotonin is reduced to a greater extent than against other tricyclic antidepressants).
The antidepressant effect is manifested already in the first week of use. It has a pronounced central and peripheral alpha-adrenergic blocking, as well as M-cholinergic, H1-histamine-blocking effect. It has a central analgesic, anti-bulemic effect, effective for bedwetting. Clomipramine has a wide range of other pharmacological effects: alphaone-adrenolytic, anticholinergic, antihistamine and antiserotonergic (blockade of 5-HT receptors).
Clomipramine acts on the depressive syndrome as a whole, including especially its typical manifestations, such as psychomotor inhibition, depressed mood, and anxiety. The clinical great GenRX usually observed after 2-3 weeks of treatment.
Clomipramine also has a specific effect in obsessive compulsive disorders, which differs from its antidepressant effect.
The action of clomipramine in chronic pain syndromes, caused or not caused by somatic diseases, is associated with facilitating the transmission of a nerve impulse mediated by serotonin and norepinephrine.
The psychostimulating effect is less pronounced than that of imipramine, and the sedative effect is weaker than that of amitriptyline.
Zonisamide Actavis Absorption is fast, almost 100%, bioavailability is about 50% (the effect of "first passage" through the liver). After a single oral administration of 50 mg, the maximum concentration in the blood (TCmax) of clomipramine is 4 hours, and its desmethylated metabolite (which is a potent inhibitor of reuptake of norepinephrine) 4-24 hours.
In patients receiving clomipramine at a dose of 25 mg Clomipramine times a day, the equilibrium concentration of the drug in plasma is created by the end of the first week of treatment and present for clomipramine and desmethyl clomipramine - 113 and 184 ng / ml, respectively, and in patients taking 75 mg alone once a day in the evening, respectively, 70 and 81 ng / ml.
Communication with plasma proteins is 97.6%.
Distribution volume - 12–17 l Clomipramine kg. Concentration in cerebrospinal fluid - 2% of that in blood plasma, in breast milk - similar to plasma.
The half-life (T1/2) - 21 hours. Patients with depression may have an elongation of T1/2 up to 36 another drug. 2/3 in the form of water-soluble compounds are excreted by the kidneys, approximately 1/3 through the intestines. The amount of unchanged clomipramine and its active metabolite excreted by the kidneys is not more than 1% of the dose taken, the rest is excreted in the form of hydroxylated metabolites.
Pharmacokinetics in individual patient groups
In elderly patients, regardless of the dose of clomipramine used, due to a decrease in the metabolism of clomipramine, its plasma concentration is higher than in patients with a younger age. The effect of impaired liver and kidney function on the pharmacokinetics of clomipramine is not well understood.
Clomipramine: Indications
- Treatment of depressive conditions of various etiologies, proceeding with various symptoms:
