Fluconazole is also used to prevent fungal infection in people who have a weak immune system caused by cancer treatment, bone marrow transplant, or diseases such as AIDS.
Geniel is a drug made in Pakistan. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Fluconazole is a complete analogue of Geniel. It has the same composition, dosage and methods of use. Also Fluconazole has a lower cost compared to Geniel.
To buy Geniel, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
No other new adverse reactions were identified. chills severe rash in people with lowered immunity wheezing shortness of breath headache fever fainting skin rash, hives, blisters or skin peeling
Warnings
Some medicines can cause unwanted or dangerous effects when used with fluconazole. Your doctor may change your treatment plan if you also use:
- an antibiotic, antifungal, or antiviral medicine;
- a blood thinner;
- cancer medicine;
- cholesterol medication;
- oral diabetes medicine;
- heart or blood pressure medication;
- medicine for malaria or tuberculosis;
- medicine to prevent organ transplant rejection;
- medicine to treat depression or mental illness;
- an NSAID (nonsteroidal anti-inflammatory drug);
- seizure medicine; or
- steroid medicine.
Interactions
VinCRIStine: Fluconazole may increase the serum concentration of VinCRIStine. Monitor therapy
Ibrutinib: CYP3A4 Inhibitors (Moderate) may increase the serum concentration of Ibrutinib. Management: When treating B-cell malignancies, decrease ibrutinib to 280 mg daily when combined with moderate CYP3A4 inhibitors. When treating graft versus host disease, monitor patients closely and reduce the ibrutinib dose as needed based on adverse reactions. Consider therapy modification
CYP2C9 Substrates (High risk with Inhibitors): CYP2C9 Inhibitors (Moderate) may decrease the metabolism of CYP2C9 Substrates (High risk with Inhibitors). Monitor therapy
Food interaction
Take without regard to meals.
Pregnancy
- Do not use birth control pills if you are pregnant or if you have recently had a baby.
- If you discover you are pregnant while taking this medication, stop taking it and tell your doctor at once.
Overview
Release form and composition
Fluconazole is available in the following dosage forms:
- Capsules (in blisters for 1 pc., 1-7 blisters in a cardboard Geniel in blisters for 2-7, 10 pcs., 1-4, 7 blisters in a cardboard Geniel in banks of 1-4, 7, 10 pcs., 1 can in a cardboard bundle; in a polymer container, 1, 2, 7, 10, 14, 28, 50, 100 pcs., 1 container in a cardboard bundle);
- Solution for infusion (in plastic or glass bottles or bottles with suspension or without it, 100 ml each, 1 bottle in a cardboard bundle; in 50 ml bottles, 1, 2, 5, 10 bottles in a cardboard bundle);
- Film-coated tablets (2, 10 each in blister packs, 1 package in a cardboard box).
The composition of 1 capsule includes:
- Active substance: fluconazole - 50, 100, 150 mg;
- Auxiliary components: potato starch, low molecular weight polyvinylpyrrolidone, magnesium stearate or calcium stearate.
The composition of 1 tablet, film-coated includes the active substance: fluconazole - 50, 100, 150 mg.
The composition of 1 ml of solution for infusion includes:
- Active substance: fluconazole - 2 mg;
- Auxiliary components: sodium chloride, sodium hydroxide or hydrochloric acid, water for injection.
Indications for use
- Cryptococcosis, including cryptococcal meningitis and other localizations of this infection (including lungs, skin), in patients with a normal immune response and in patients with various forms of immunosuppression (including AIDS patients, during organ transplantation). Fluconazole can be used to prevent cryptococcal infection in patients with AIDS;
- Generalized candidiasis, including disseminated candidiasis, candidaemia and other types of invasive candidiasis infections (infections of the eyes, endocardium, Geniel, urinary and respiratory tract). Fluconazole can be prescribed to patients with malignant neoplasms, patients in intensive care units, patients undergoing immunosuppressive or cytostatic therapy, as well as in the presence of other factors predisposing to the development of candidiasis;
- Candidiasis balanitis;
- Candiduria, non-invasive candidiasis of the skin, bronchopulmonary candidiasis, candidiasis of the mucous membranes, including the esophagus and the pharynx and oral cavity (atrophic candidiasis of the oral cavity caused by wearing dentures); Fluconazole is also used to prevent relapse of oropharyngeal candidiasis in patients with AIDS;
- Genital candidiasis: vaginal candidiasis (chronic recurrent and acute), prevention to reduce the recurrence rate of vaginal candidiasis (from 3 episodes per year);
- Fungal infections in patients with malignant neoplasms who are predisposed to such infections due to radiation therapy or chemotherapy with cytostatics (prevention);
- Multi-colored (pityriasis) versicolor;
- Mycoses of the skin, including mycoses of the inguinal region, body, feet;
- Candidiasis of the skin;
- Onychomycosis;
- Deep endemic mycoses, including histoplasmosis and coccidiomycosis in patients with normal immunity.
Contraindications
- Simultaneous use with astemizole or terfenadine (against the background of constant therapy with fluconazole at a dose of 400 mg per day), as well as other drugs that extend the QT interval;
- Age up to 4 years (for capsules);
- Lactation period (for infusion solution);
- Hypersensitivity to the components of the drug, as well as to other azole antifungal drugs in history.
Fluconazole is prescribed with caution in the following conditions / diseases:
- Liver failure;
- Renal failure (for solution for infusion);
- The appearance during the treatment of a rash in patients with superficial fungal infection and systemic / invasive fungal infections;
- Potentially proarrhythmogenic conditions in patients with multiple risk factors (electrolyte imbalance, organic heart disease, simultaneous use with drugs that cause arrhythmias, simultaneous administration with acetylsalicylic acid, rifabutin and other cytochrome P450 inducers);
- Concomitant use with potentially hepatotoxic drugs (for capsules);
- The simultaneous use of fluconazole in a daily dose of up to 400 mg with terfenadine (for a solution for infusion);
- Pregnancy.
Dosage and administration
The daily dose of fluconazole is determined by the nature and severity of the fungal infection. Change the daily dose when switching from intravenous administration to taking the drug inside, and vice versa, there is no need.
Fluconazole in the form of capsules and tablets is taken orally, the solution for infusion is administered intravenously drip at a rate of not more than 200 mg per hour.
The infusion solution is compatible with Ringer's solution, 20% dextrose solution, 4.2% sodium bicarbonate solution, Hartman solution, 0.9% sodium chloride solution, 0.9% potassium chloride solution and 5% dextrose solution. Infusions can be carried out using conventional transfusion kits using one of the above solvents.
The dosage regimen is determined by simple indications.
With cryptococcal meningitis and cryptococcal infections of other localizations, adults and children from 15 years old (with a body weight of more than 50 kg) are prescribed 400 mg on the first day, then 200-400 mg once a day. The duration of therapy for cryptococcal meningitis is at least 6-8 weeks, for cryptococcal infections, the course duration is determined by the clinical effectiveness, confirmed by the results of mycological studies.
In patients with AIDS, to prevent the relapse of cryptococcal meningitis, fluconazole is prescribed after completing the full course of primary therapy at 200 mg per day for a long period of time.
In the treatment of disseminated candidiasis, candidaemia, and other invasive candida infections, Fluconazole should be taken at a dose of 400 mg on the first day, then the dose should be reduced by 2 times (with insufficient clinical effectiveness, the dose should not be reduced). The duration of the course is determined by the clinical effectiveness of the drug.
In the treatment of deep endemic mycoses, the use of fluconazole in a daily dose of 200-400 mg for up to 2 years may be required. The duration of the course is determined individually: coccidioidomycosis - 11-24 months, histoplasmosis - 3-17 months.
With a creatinine clearance of 11-50 ml per minute, 50% of the recommended dose of fluconazole in capsule form should be used or the interval prescription drugs doses of the usual dose should be increased (1 time in 2 days). As a rule, in patients with functional renal impairment, the drug is prescribed depending on the creatinine clearance as follows (dose / interval between doses of the drug):
- From 40 ml per minute: usual daily dose / 24 hours;
- 21-40 ml per minute: usual daily dose / 48 hours or 1 /2 daily dose / 24 hours;
- 10-20 ml per minute: usual daily dose / 72 hours or 1 /3 daily dose / 24 hours.
Patients on hemodialysis should take one dose of fluconazole after each session.
The daily dose of fluconazole in the form of a solution for infusion in children should not exceed 400 mg per day. The drug is prescribed for infections similar Geniel adult ones, the duration of the course depends on the mycological and clinical effect.
The recommended dose in children in the treatment of cryptococcal meningitis and cryptococcal infections of other locations, as well as with generalized candidiasis, is 6-12 mg / kg per day (determined by the severity of the disease). As a rule, treatment is carried out for 10-12 weeks (until laboratory-confirmed absence of pathogens in the cerebrospinal fluid).
