Butorphanol is used to treat moderate to severe pain.
Butordyne is a drug made in Australia. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Butorphanol is a complete analogue of Butordyne. It has the same composition, dosage and methods of use. Also Butorphanol has a lower cost compared to Butordyne.
To buy Butordyne, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Call your doctor for medical advice about side effects. clammy skin difficulty breathing Managing Side Effects not breathing fever swelling in hands and feet nasal irritation congestion
Warnings
To make sure this medicine is safe for you, tell your doctor if you have ever had:
- any type of breathing problem or lung disease;
- liver or kidney disease;
- a head injury, brain tumor, or seizures;
- heart disease, high blood pressure, recent heart attack; or
- alcoholism, drug addiction, mental illness.
Butorphanol nasal can pass into breast milk and may cause drowsiness or breathing problems in a nursing baby. Tell your doctor if you are breast-feeding a baby.
You should not use butorphanol if you are allergic to it, or if you have:
- severe asthma or breathing problems; or
- a stomach or bowel obstruction (including paralytic ileus).
Interactions
Oxomemazine: May enhance the CNS depressant effect of CNS Depressants. Avoid combination
Kava Kava: May enhance the adverse/toxic effect of CNS Depressants. Monitor therapy
Nalmefene: May diminish the therapeutic effect of Opioid Agonists. Management: Avoid the concomitant use of nalmefene and opioid agonists. Discontinue nalmefene 1 week prior to any anticipated use of opioid agonistss. If combined, larger doses of opioid agonists will likely be required. Consider therapy modification
Food interaction
Avoid alcohol.
Pregnancy
- If you become pregnant while taking this drug, call your doctor right away.
- Taking this medicine during pregnancy may affect tooth and bone development in the unborn baby.
- However, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant.
Overview
At the cellular level, the mechanism of action of Butorphanol is associated with blocking the release of potassium and calcium ions, which leads to a prolongation of the state of hyperpolarization of the cell, thereby interrupting the transmission of an electrical impulse between neighboring nerve cells. The third way to realize the analgesic effect is achieved by stopping the reuptake of neurotransmitter hormones - dopamine and norepinephrine.
Butorphanol refers to high-speed drugs that can remove pain, as well as provide anesthesia.
The drug fully reaches the systemic circulation 10 minutes after prescription administration and 15-20 minutes after ingestion through the nasal mucosa. Up to 80% of the drug binds to blood proteins, mainly with albumin.
Due to the small size of the molecule of the main substance, butorphanol quietly penetrates the body’s barrier systems - transplacental and blood-brain. The metabolism of the active substance occurs in hepatocytes and other structures of the hepatobiliary system. In the form of metabolites, the drug is excreted by the kidneys. In unchanged form, no more than 5% of the substance is excreted. It is also possible to withdraw the drug during lactation through mother's milk.
The maximum effect occurs 30 minutes after parenteral administration and can persist up to 3-4 hours. The prolongation of the effect is observed in Butordyne with impaired renal function, as well as in persons older than 75 years.
Indications and contraindications
The main indication for the appointment of Butorphanol is severe severe or moderate pain. Most often, the appointment of the drug is necessary in such cases:
- with postoperative pain;
- in cancer patients;
- with renal colic;
Butordyne pain relief during childbirth; - for sedation and balanced anesthesia.
Symptoms of Renal Colic
Among the contraindications, the first place is taken by the individual intolerance to the drug and its components, the period of pregnancy (except for childbirth) and breastfeeding. Also, the use of the drug in the treatment of patients under 18 years of age is not recommended, since appropriate clinical studies have not been conducted regarding its safety.
According to the FDA, the drug can affect the fetus, but no reliable clinical trials have been conducted. In this case, it is possible to prescribe and use a medicinal substance only after assessing the degree of risk and a possible positive result.
Instructions for use
Before administering the drug, it is necessary, without removing the cap from the needle, screw it onto the syringe tube until the solution fills the entire needle. Gently, squeezing the tube with your fingers, let out air, then, without unclenching your fingers, enter the drug.
For intramuscular administration should start with a dosage of 2 mg. In cases where it is necessary to prolong the action of Butorphanol, the dose can be individually increased by 1-4 mg every 3-4 hours, based on hemodynamic and respiratory indicators.
With intravenous administration, the starting dose is 1 mg. Depending on the strength of the pain syndrome, the dose range is from 0.5 to 2 mg every 4 hours.
Drug interaction
Butorphanol should not be prescribed simultaneously with drugs that affect the central nervous system, for example, tranquilizers, antihistamines, ethanol and alcohol derivatives, barbiturates. In case of their interaction, the development of severe neurological disorders is possible, up to a fatal outcome.
Butorphanol with monoamine oxygenase inhibitors is used with caution, as this can lead to a sharp increase in arterial and intracranial pressure, up to the development of hyperpyrexic coma.
The use of the drug against the background of alcohol intoxication is contraindicated due to the increase in neurological symptoms, this can lead to respiratory failure.
Adverse Reactions and Overdose
Despite the fact that the drug is characterized by side effects common to all opioid analgesics, butorphanol is several times superior in safety to morphine. However, frequent adverse reactions can be drowsiness, a feeling of heat, dry mouth, a change in blood pressure, as well as impaired consciousness up to euphoria.
