Budesonide is used to treat mild to moderate Crohn's disease.
Butacort 100 is a drug made in New Zealand. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Budesonide is a complete analogue of Butacort 100. It has the same composition, dosage and methods of use. Also Budesonide has a lower cost compared to Butacort 100.
To buy Butacort 100, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Tell your doctor right away of any new symptoms that occur during or after treatment. osteoporosis or low bone mineral density; a serious bacterial, viral, or fungal infection; stomach ulcer; nausea, vomiting, rectal bleeding; pain or burning when you urinate; cirrhosis or other liver disease; eczema; thinning skin, easy bruising, increased acne or facial hair;
Warnings
Budesonide is not approved for use by anyone younger than 18 years old.
You should not breast-feed while using this medicine.
You should not use budesonide if you are allergic to it.
Interactions
Amphotericin B: Corticosteroids (Orally Inhaled) may enhance the hypokalemic effect of Amphotericin B. Monitor therapy
Loop Diuretics: Corticosteroids (Orally Inhaled) may enhance the hypokalemic effect of Loop Diuretics. Monitor therapy
Hyaluronidase: Corticosteroids may diminish the therapeutic effect of Hyaluronidase. Management: Patients receiving corticosteroids (particularly at larger doses) may not experience the desired clinical response to standard doses of hyaluronidase. Larger doses of hyaluronidase may be required. Consider therapy modification
Food interaction
A mean delay in time to peak concentration of 2.5 hours is observed with the intake of a high-fat meal, with no significant differences in AUC.
Pregnancy
- If bleeding persists or occurs after previously regular cycles, check for causes such as pregnancy or malignancy.
- Safety for cats that are breeding, pregnant, or lactating also has not been demonstrated due to a lack of adequate studies.
Overview
Inhaled budesonide is rapidly absorbed. After inhalation, about 25-35% of read more dose received passes into the lungs. The peak plasma concentration is reached 30 minutes after inhalation. Systemic 100 of the drug is 39% of the dose taken.
The volume of distribution of budesonide is approximately 3 L / kg. The binding of budesonide to plasma proteins is 85-90%.
After absorption, budesonide undergoes an intensive metabolism (more than 90%) of the Xultophy passage in the liver with the formation of metabolites with low glucocorticosteroid activity. The glucocorticosteroid activity of the main metabolites of 6ß-hydroxybudesonide and 16ą-hydroxyprednisolone is less Butacort 1% of the glucocorticosteroid activity of budesonide. Metabolism occurs using the enzyme CYP3A4.
Metabolites here excreted unchanged in urine (60%) and in feces.
Budesonide has a high systemic clearance (1.4 l / min). The pharmacokinetics of budesonide is proportional to the magnitude of the administered dose of the drug.
Pharmacokinetics of budesonide in children: the systemic bioavailability of budesonide is the same as in adults.
Pharmacokinetics in patients with impaired liver function (liver failure): the period of elimination of budesonide increases.
Pharmacodynamics
Budesonide is a topical anti-inflammatory glucocorticosteroid.
The exact mechanism of Butacort of glucocorticosteroids in 100 treatment of bronchial asthma is not 100 understood. An anti-inflammatory effect, such as inhibiting the release of inflammatory mediators and a cytokine-mediated immune response, is perhaps the most important. The affinity of the active substance budesonide to 100 receptors is 15 times higher than that of prednisolone.
The anti-inflammatory effect is manifested by Butacort decrease in the degree of airway obstruction in the early and late stages of allergic reactions. Budesonide reduces the activity of histamine and methacholine in the respiratory tract of hyperreactive patients.
The drug has a preventive effect on the course of bronchial asthma and does not affect allow acute manifestations of the disease.
A dose-dependent effect on the content of cortisol in plasma and urine with budesonide has been proven. In recommended doses, the drug has a significantly Butacort effect on adrenal function than prednisolone at a dose of 10 mg, as was shown in ACTH tests.
Indications for use
Dosage and administration
The drug is used to prevent exacerbation of bronchial asthma; use in an acute attack is not practical.
Dose of Busonide, aerosol for inhalation, selected individually.
Adults, including the elderly and children over 12 years of age: 200 mcg twice a day (morning and evening). For the treatment of severe exacerbation of bronchial asthma, the daily dose may be increased to 1600 mcg.
Dose should be reduced to the minimum necessary to maintain good asthma control.
