Busulfan oral (taken by mouth) is used to treat the symptoms of chronic myelogenous leukemia (a type of blood cancer). Busulfan is not a cure for leukemia.
Busulfan Apotex is a drug made in Australia. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Busulfan is a complete analogue of Busulfan Apotex. It has the same composition, dosage and methods of use. Also Busulfan has a lower cost compared to Busulfan Apotex.
To buy Busulfan Apotex, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
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Side effects
Severe adverse reactions reported in the study included
Warnings
Some people treated with busulfan have developed new forms of cancer. Talk to your doctor about your specific risks and benefits of using this medicine.
You should not use busulfan if you are allergic to it.
Busulfan can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.
- If you are a woman, do not use busulfan if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
- If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
- Tell your doctor right away if a pregnancy occurs while either the mother or the father is using busulfan.
Interactions
Tertomotide: Immunosuppressants may diminish the therapeutic effect of Tertomotide. Monitor therapy
Mesalamine: May enhance the myelosuppressive effect of Myelosuppressive Agents. Monitor therapy
Lipegfilgrastim: Antineoplastic Agents may diminish the therapeutic effect of Lipegfilgrastim. Management: Avoid concomitant use of lipegfilgrastim and myelosuppressive cytotoxic chemotherapy. Lipegfilgrastim should be administered at least 24 hours after the completion of myelosuppressive cytotoxic chemotherapy. Consider therapy modification
Food interaction
Take without regard to meals.
Drink liberally.
Pregnancy
- Topical corticosteroids should not be used by pregnant women over large areas of the body, in large amounts, or for prolonged periods of time.
- Females will need to have 2 negative pregnancy tests before starting this medicine and then monthly pregnancy tests during treatment, even if you are not sexually active.
- You can also start taking this pill at any other time in your cycle if your doctor is reasonably sure that you are not pregnant.
Overview
Storage conditions:
The drug from the list B. In a dark information
Synonyms:
Preparations of a similar action:
Amsacrine (Amsacrine) Dibunolum (Dibunolum) Procarbazine (Procarbazin) Mitoxantrone (Mitoxantrone) Hydroxyurea (Hydroxyurea)
No information needed?
An even more complete guide Busulfan busulfan can be found here:
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Instructions for use
Antitumor agent alkylating action. It has a cytostatic effect on myeloid cells. At relatively low doses, granulocytopoiesis Busulfan inhibits.
After oral administration, it is completely absorbed from the digestive tract. Rapidly metabolized Apotex the liver. T 1/2 is about 2.5 hours. Excreted by the kidneys, almost completely in the form of metabolites.
CONTRAINDICATIONS BUSULFAN
Inhibition of bone marrow function, pregnancy, hypersensitivity Apotex busulfan.
It is not recommended for use in patients with chickenpox (including recently transferred or after contact with patients), with herpes zoster, other acute infectious diseases, gout or nephrolithiasis (including a history).
Use with caution in cases with a history of convulsive seizures, traumatic brain injury; during treatment with drugs that increase the risk of seizures; in patients previously treated with cytotoxic antitumor agents or radiation therapy.
With busulfan, patients and their family members should not be vaccinated.
Close monitoring of the picture of peripheral blood should be carried out 1 time per week during the induction of remission and at least 1 time in 4 weeks - with maintenance therapy. Busulfan should be discontinued in cases of a decrease in the number of leukocytes to 2000-2500 / μl or a decrease in the number Apotex platelets to 100,000 / μl.
Against the background of the use of busulfan, it is necessary to periodically monitor the activity of hepatic transaminases and alkaline phosphatase, as well as the level of bilirubin in the blood plasma.
In patients with hyperuricemia and / or hyperuricosuria, correction of these disorders is required before starting treatment with busulfan.
In children, busulfan is used in very rare cases for strict indications.
The carcinogenic and mutagenic effects of busulfan have been established in experimental studies.
Busulfan is contraindicated in pregnancy. If necessary, use during lactation should stop breastfeeding.
Women of childbearing age while using busulfan Busulfan use reliable methods of contraception.
From the hemopoietic system: myelodepression (thrombocytopenia, leukopenia, less often - anemia); in some cases, irreversible bone marrow aplasia.
From the respiratory system: in some cases - interstitial pulmonary fibrosis.
From the digestive system: nausea, vomiting, diarrhea, stomatitis, loss of appetite; in some cases (with prolonged Apotex as Busulfan of combination therapy) - hepatotoxic effect, the development of varicose veins of the esophagus, hepatic vein thrombosis.
