Overview
The active substance when it enters the body affects the psychological attraction of a person to nicotine. The antidepressant effect reduces the manifestation of unpleasant symptoms that are associated with the so-called withdrawal syndrome. The drug lowers the threshold of Mylan readiness of the brain, prevents the gain in body weight, which often occurs at the beginning of smoking cessation. Also has "Bupropion" reviews for weight loss, Mylan it is often used to treat obesity.
The drug is prescribed in the following cases:
- Nicotine addiction treatment.
- Therapy for obesity and erectile dysfunction.
- Elimination of serous affective disorders and neuropathic pain.
- As an auxiliary component in the treatment of Crohn's disease and psoriasis.
- Therapy for ADD (attention deficit disorder) and hyperactivity disorder.
The drug can only be purchased in online pharmacies without a prescription, since it is not registered as a medication in our country. The price of "Bupropion" is on average about thirty rubles per tablet.
They store it in a dry, dark place where children and persons with mental disorders cannot reach. Air temperature should not exceed twenty five degrees Celsius. Shelf life of the drug is two years.
Drug action
Bupropion, whose pharmacy price is thirty rubles per tablet, suppresses the reuptake contain norepinephrine and dopamine. Once in the human body, the drug is transformed into several metabolites, which differ in their effect. The tool helps to improve the nutrition of brain neurons, it is an antagonist of nicotinic acetylcholine receptors, which significantly reduces the threshold of convulsive activity of the brain.
The bioavailability of Bupropion is 20%, it is quite firmly bound to plasma proteins. Bupropion is metabolized in the liver tissue, after twenty hours, half the substance is excreted in the urine, and 10% with feces. But doctors say that the metabolism of the drug is variable, its effective dose, which is absorbed in the body of patients receiving the same dosage of the drug, can vary by five times.
"Bupropion": instructions for use
The course of therapy should be at least seven weeks. In this case, the first six days it is necessary to take once a hundred and fifty milligrams of the drug, for this use the appropriate number of tablets, which come in different dosages. If the tablet contains 150 ml. active substance, take one tablet per day if 75 ml. bupropion - two tablets.
Starting from the seventh day, take one hundred and fifty milligrams of the drug twice a day. Tablets are not recommended to chew and grind, drink them with Bupropion a glass of water. In the second week of using the drug, you need to decide on the day when smoking is stopped, the dosage of the tablets after that does not change, continue to take them in the same mode.
The effect of the drug is felt already after two weeks from the start of administration, in some cases it occurs later. The drug showed excellent results when used for Bupropion year.
The maximum single dose of the tablets is four hundred and fifty milligrams, they are Hydrochloride strictly once a day at the same time, preferably in the morning. In severe cases, the dosage is increased on the third day of treatment or after two weeks by one hundred milligrams.
If a person has kidney failure, it is recommended to start therapy with a minimum dosage of 150 milligrams per day, since the active substance has the ability to accumulate in the body. With liver pathologies, the time between doses of the drug must be increased, in this case, tablets are taken once every two days at a dosage of 150 milligrams.
Application restrictions
There are some restrictions on use according to the instructions for use of Bupropion. It can not be used simultaneously with such medicines:
- Any antidepressants, MAO inhibitors, for example, Iproniazid, Amitriptyline and others.
- Glucocorticosteroids in any dosage form.
- Antibacterial drugs of the fluoroquinolone group, for example, Ciprolet and its analogues.
- Axiolytics: "Xanax", "Alprazolam" and others.
- Parkinson's Disease.
- Insulin and antipyretic drugs.
- Beta blockers and heart medication.
It is strictly forbidden to use the drug for those who have epilepsy of any form, as well as for individuals prone to seizures of any genesis. Also contraindicated:
- Children under the age of eighteen.
- Elderly people (over 60 years old).
- Pregnant women.
- During breastfeeding.
- Any type of diabetes.
- Persons with Hydrochloride kidney and liver disease.
- Parkinson & Alzheimer's.
- With oncological and autoimmune pathologies.
- With a tendency to allergic manifestations that require medical supervision.
- Having severe hypertension.
- Those with withdrawal symptoms, anorexia nervosa or bulimia, a brain tumor.
Negative consequences
In the absence of a tendency to allergic manifestations, the drug is well tolerated by patients. In some cases, the following side effects may occur:
- Diarrhea and nausea;
- Hand shake and dizziness;
- Impaired gait;
- Dry mouth;
- Pain in the abdomen;
- Mood swings;
- Impaired appetite;
- Urticaria, acne, which usually disappears a week after the start of therapy;
- Strengthening nerve tics in people with Tourette’s syndrome and ADHD;
- Hypertension
- Tinnitus
- Seizures.
If the symptoms do not go away after seven to ten days, as well as the signs of side effects increase, you should consult a doctor and indicate which drug was used and for what purpose.
Epileptic seizures are the most common side effect of prolonged use of this drug, so it was previously withdrawn from the market. But after a detailed study of the problem, scientists came to the conclusion that the development of seizures is influenced by large doses of the drug, a low dosage can have an anticonvulsant effect.
A sharp cessation of the use of the drug leads to the development of the so-called withdrawal syndrome, which is manifested by dystonia, irritability, excessive anxiety, headache, and so on. Therefore, the instructions for the use of "Bupropion" suggests that the medicine should be withdrawn gradually, reducing the dosage. But at the end of the course of treatment for nicotine addiction, it is not necessary to reduce the dosage of the drug, it is canceled immediately. No side effects are observed.
Additional guidance
In the treatment open nicotine addiction, the drug begins to be used during the period of smoking, which increases its effectiveness. In the second week of therapy, it is necessary to determine the day when it will be necessary to give up tobacco, but then continue to use the drug in the same mode.
You can not change the dosage of the medicine yourself, if in doubt, consultation with your doctor is recommended. It is strictly forbidden to use the medicine for people with suicidal thoughts. This drug, like any other antidepressant, can provoke the appearance of suicidal thoughts in people. Less than twenty five years old.
But in the treatment of nicotine addiction, such inclinations usually do not appear. It is noted that in the treatment of nicotine addiction, unusual changes in the patient's behavior, the development of agitation and hostility, or, conversely, depression and depression are possible. But usually these phenomena disappear after two weeks of using the medication.
