Buprenorphine implant (placed under the skin) is used to treat opioid addiction in certain people whose addiction has already been controlled with other forms of buprenorphine. The implant is for adults and teenagers who are at least 16 years old.
Buprelieve is a drug made in United Kingdom. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Buprenorphine is a complete analogue of Buprelieve. It has the same composition, dosage and methods of use. Also Buprenorphine has a lower cost compared to Buprelieve.
To buy Buprelieve, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
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Side effects
Your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. trouble sleeping unusual weight gain or loss bloody or cloudy urine mental depression slow or shallow breathing, blurred vision difficulty swallowing dizziness,
Warnings
Tell your doctor if you have ever had:
- any type of breathing problem or lung disease;
- liver disease;
- problems with your gallbladder or thyroid;
- an enlarged prostate, urination problems;
- Addison's disease (an adrenal gland disorder);
- abnormal curvature of the spine that affects breathing;
- a head injury, brain tumor, or spinal cord problems;
- mental illness or psychosis;
- alcoholism; or
- skin problems such as unusual scars or growths.
Interactions
Erdafitinib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
Mitotane: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane. Consider therapy modification
Naltrexone: May diminish the therapeutic effect of Opioid Agonists. Management: Seek therapeutic alternatives to opioids. See full drug interaction monograph for detailed recommendations. Consider therapy modification
Food interaction
Pregnancy
- This medication may be given to a pregnant woman if her healthcare provider believes that the benefits to the pregnant woman outweigh any possible risks to her unborn baby.
- In addition, in women who had LH surges of longer duration, the difference in pregnancy rates between low and high LH levels was only 20 percent versus 23.
- Studies in animals have shown an increase in birth defects.
Overview
It is available in several dosage forms: buprenorphine in ampoules with a solution for intravenous and intramuscular injection (0.03% in 1 ml), sublingual tablets of buprenorphine (0.2 g of buprenorphine hydrochloride in a package of 10 to 100 pcs) and in blisters.
Mechanism of action
The speed of the drug is different from the form of release. With intravenous administration, the effect is observed less than in a minute and reaches its maximum concentration in 20 minutes. With intramuscular - it is felt after 15 minutes. With sublingual - after 30 minutes.
The analgesic effect lasts from six to eight hours. The maximum dosage is 1.2-1.5 mg, but respiratory failure begins.
You can not grind the Buprelieve in the form of tablets and breed it for injection. This not only does not improve the result, but also leads to death.
Thirty times stronger than morphine buprenorphine
The analgesic effect of buprenorphine is almost thirty times higher than morphine, so 0.3 mg of this drug is 10 mg of morphine.
After administration, a strong analgesic effect and mild euphoria occur. Moreover, it is less toxic and less often highly addictive.
The mechanism of action of buprenorphine, like other agonists, is aimed at interacting with mu- (μ-) and kappa- (κ-) opioid receptors, which is the reason for the decrease in pain and satisfaction.
At the same time, the connection of the drug with μ receptors is strong, because of which the suppression of all other agonists.
Own activity with μ receptors is weak, but with κ receptors not found. Therefore, buprenorphine can be attributed to Buprelieve group of partial antagonists that contribute to treatment for opioid addiction.
Buprenorphine abuse
Semi-synthetic opioid causes negative consequences if the patient has a number of diseases, for example:
- respiratory failure (asthma, chronic obstructive pulmonary disease);
- hepatitis B, C;
- kidney and thyroid problems;
- deviations in the work of the stomach;
- pathology of the gallbladder;
- violations in the activity of the adrenal glands;
- mental illness.
When providing first aid, it is worth informing the doctor about chronic diseases from this Buprelieve
Subutex is one of the trade names for buprenorphine
On the territory of the Russian Federation, buprenorphine is included in List II of Narcotic drugs and psychotropic substances, the circulation of which in the Russian Federation is limited. According to Russian legislation, the release and sale of the drug are under strict control.
