Bupivacaine is given as an epidural injection into the spinal column to produce numbness during labor, surgery, or certain medical procedures.
Bupivacaine Hydrochloride 0.5% Mercury is a drug made in Malta. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Bupivacaine is a complete analogue of Bupivacaine Hydrochloride 0.5% Mercury. It has the same composition, dosage and methods of use. Also Bupivacaine has a lower cost compared to Bupivacaine Hydrochloride 0.5% Mercury.
To buy Bupivacaine Hydrochloride 0.5% Mercury, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. hearing loss numbness or tingling; a bleeding or blood clotting disorder; Professional chest pain or discomfort discouragement slow heart rate, weak pulse; feeling sad or empty
Warnings
Tell your doctor if you are breast-feeding.
Tell your doctor if you have ever had an allergic reaction to any type of numbing medicine, or if you've ever had:
- anemia (lack of red blood cells);
- kidney or liver disease;
- a bleeding or blood clotting disorder;
- syphilis, polio, a brain or spinal cord tumor;
- numbness or tingling;
- chronic back pain, headache caused by surgery;
- low or high blood pressure;
- abnormal curvature of the spine; or
- arthritis.
Interactions
Nicorandil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Quinagolide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Food interaction
Pregnancy
- Luvox during pregnancy without first talking with your doctor.
- The researchers found that the protocols were more than 95 percent effective up to 63 days of pregnancy, according to Emily Crockett at RH RealityCheck.
Overview
Despite this, during the use of the drug, breastfeeding should be discontinued.
Interaction with other drugs
Local anesthetics or drugs similar in structure to local amide type anesthetics, such as class Ib antiarrhythmic drugs (lidocaine, mexiletine) increase the risk of an additive toxic effect.
Joint application Bupivacaine class III antiarrhythmic drugs (for example, amiodarone) have not been studied separately, but caution is advised when prescribing these drugs (see section "Special Instructions").
Monoamine oxidase inhibitors or tricyclic antidepressants increase the risk of a pronounced increase element blood pressure.
Drugs containing oxytocin or ergotamine effects to the development of a steady increase in blood pressure with possible complications from the cardiovascular and cerebrovascular system.
Combination with halothane general inhalation anesthesia increases the risk of arrhythmia.
When treating the injection site of local anesthetic with disinfectant solutions containing heavy metals, the risk of developing a local reaction in the form of pain and swelling increases.
Drugs structurally similar to local anesthetics, for example, tocainide, increase the risk of an additive toxic effect.
Local anesthetics increase central nervous system depression caused by drugs that inhibit the central nervous system.
The solubility of bupivacaine decreases at pH> 6.5, this should be taken into account if alkaline solutions are added, as precipitate may form.
Overdose
When cardiac arrest, they immediately begin cardiopulmonary resuscitation. Optimizing oxygenation and ventilation and maintaining circulation along with correcting acidosis are vital, since hypoxia and acidosis will enhance the systemic toxic effects of a local anesthetic. Epinephrine should be administered as soon as possible (0.1-0.2 check intravenously or intracardially); if necessary, administration should be repeated.
Cardiac arrest may require prolonged resuscitation.
Storage conditions
A drug Hydrochloride should be stored at a temperature not exceeding 25 ° C. Do not freeze.
Keep out of the reach of children.
Release form
Bupivacaine - Injection, 5 mg / ml.
Packing: 4, 10, 20 ml in ampoules of colorless glass.
5 ampoules are placed in blister packs of a film of polyvinyl chloride and foil of aluminum printed varnished or without foil.
1, 2 blister packs are placed in packs of cardboard.
Instructions for use are put in each pack or box, the ampule is Mercury scarifier. The ampoule scarifier is not inserted when using ampoules with a kink ring or with an incision and a point.
20 ml per vial of colorless glass.
5 vials are placed in cardboard boxes.
5 vials are placed in blister packs of a film of polyvinyl chloride and foil of aluminum printed varnished or without foil.
1 blister strip packaging is placed in a pack of cardboard.
In each other or box put instructions for use.
Structure
Bupivacaine ml Bupivacaine contains the active substance: bupivacaine hydrochloride - 5.0 mg.
Excipients: sodium chloride - 8.0 mg, disodium edetate dihydrate (disodium salt of ethylenediamine-N, N, N ′, N′-tetraacetic acid 2-aqueous (Trilon B)) - 0.1 mg, 1 M sodium hydroxide solution - up to pH 4.0-6.5, water for injection - up to 1 ml.
Action description
Long-acting synthetic amide local anesthetic. Reversibly reduces the permeability of the cell membrane of a neuron to sodium ions, thereby blocking the conductivity of the effective potential. Anesthetic effect manifests itself at different times after administration of the drug, depending on the type of anesthesia and the drug used (the Bupivacaine use of vasopressors, for example, epinephrine with bupivacaine, reduces the waiting time for the anesthetic effect, and also reduces absorption from the injection site). The drug acts more on sensory fibers than on motor fibers. The sequence of the anesthetic effect is as follows: pain, temperature, touch, deep sensation. Cmax depends on the injection site of Hydrochloride and the total dose administered. Cmax reaches its maximum after anesthesia of the intercostal nerves, and the smallest after subarachnoid anesthesia. The use of booster doses causes a slow accumulation of bupivacaine in the body. Bupivacaine is approximately 95% bound to plasma proteins. The drug penetrates well through the placental barrier. in adults, t1 / 2 is about 3.5 hours, in newborns - about 8 hours. The drug is metabolized in the liver, only 6% is excreted in the urine unchanged. In the case of liver dysfunction, a slowdown in metabolism and an increase in the concentration of bupivacaine in the plasma occur. Hyperbaric solution is characterized by a rapid onset of action (5-8 minutes after introduction into the subarachnoid space), anesthesia lasts about 120-180 minutes. The effect of relaxing the abdominal muscles is enough for short-term (about 45-60 minutes) operations of the abdominal cavity and longer (about 2-3 hours) operations on the lower extremities. Due to the fact that the specific gravity of the drug is higher than cerebrospinal fluid, the range of anesthesia depends on the influence of gravity, as well as on the position of the patient during administration of the drug. The introduction of the drug at the L3 – L4 level in a sitting position causes the blocking of segments below Th7 – Th10, the introduction in a lying position on the side, followed by a flip to the back — below Th4 – Th7, however, the range of anesthesia is individual. From the subarachnoid space, bupivacaine is completely absorbed in two stages: t1 / 2 is 50 and 408 minutes. The slow phase determines the rate of excretion Mercury bupivacaine.
Bupivacaine: instructions for use
The use of bupivacaine with or without epinephrine: anesthesia for long-term operations in obstetrics, surgery, ophthalmology and dentistry 0.5% anesthesia, peripheral nerve anesthesia, conduction and epidural anesthesia); pain treatment (e.g., during labor, postoperative analgesia). Hyperbaric example intended for spinal anesthesia: for urological operations and operations on the lower extremities lasting 2-3 hours, as well as for operations on the abdominal cavity lasting 45-60 minutes (including for 0.5% section).
Contraindications
