Bumetanide is diuretic that is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome.
Bumetanide P & D is a drug made in Malta. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Bumetanide is a complete analogue of Bumetanide P & D. It has the same composition, dosage and methods of use. Also Bumetanide has a lower cost compared to Bumetanide P & D.
To buy Bumetanide P & D, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
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Side effects
Your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. easy bruising, unusual bleeding, purple or red spots under your skin; Coadministration with antihypertensive agent may increase risk of hypotension May be tried if patient is allergic to furosemide unusual weakness; Careful medical supervision is required; dosing must be adjusted to patient's needs Use with caution in patients with cirrhosis nausea; or seizures,
Warnings
Tell your doctor if you have ever had:
- a heart rhythm disorder;
- liver disease;
- kidney disease (or if you are on dialysis);
- gout;
- an allergy to sulfa drugs; or
- if you are on a low-salt diet.
Tell your doctor if you are pregnant or breast-feeding.
Bumetanide is not approved for use by anyone younger than 18 years old.
Interactions
DULoxetine: Blood Pressure Lowering Agents may enhance the hypotensive effect of DULoxetine. Monitor therapy
Licorice: May enhance the hypokalemic effect of Loop Diuretics. Monitor therapy
Nicergoline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Food interaction
Take with food to reduce irritation.
Pregnancy
- However, general experience with COCs during pregnancy did not provide evidence for an actual undesirable effect in humans.
- For women taking hormonal contraception for birth control, loss of efficacy may lead to breakthrough bleeding and an increased risk for pregnancy.
Overview
pharmachologic effect
"Loop" short-acting diuretic. It violates the active reabsorption of sodium and chlorine ions in the thick segment of the ascending part of the Henle loop (may have Bumetanide additional effect on the Bumetanide tubules). Increases the excretion of potassium, calcium, Bumetanide ions, delays uric acid in the body.
It causes the expansion of peripheral veins, reduces preload, reduces the filling pressure of the left ventricle and the pressure in the pulmonary artery, reduces systemic blood pressure.
The diuretic effect after iv administration begins in a few minutes, reaching a maximum after 15-30 minutes. After oral administration, the diuretic effect develops within the first hour, reaches a maximum after 1-2 hours and continues depending on the dose of 4-6 hours.
Pharmacokinetics
After oral administration, it is rapidly absorbed from the digestive tract. Absorption may be slowed down in patients with ascites due to chronic heart failure or nephrotic syndrome. Binding to plasma proteins is 95-97%. It is metabolized in the liver (metabolism is limited, inactive metabolites are formed as a result).
T 1/2 - 1.2-1.5 h. 64% excreted by the kidneys unchanged, Bumetanide rest - with feces.
Indications of the active substances of the drug BUMETANID
ICD-10 codes
