Overview
Ibuprofen is prescribed adults and children over 12 years old inside, in tablets of 200 mg 3-4 times a day. To achieve a quick therapeutic effect, the dose can be increased to 400 mg (2 tablets) 3 times a day. When the therapeutic effect is achieved, the paediatric dose of the drug is reduced to 600-800 mg. The morning dose is taken before meals with a sufficient amount of paediatric (for faster absorption of the drug). The remaining doses are taken throughout the day after eating.
The maximum daily dose is 1200 mg (do not take more than 6 tablets in 24 hours). Take a repeated dose no more than 4 hours later. Duration of use of the drug without consulting a doctor is no more than 5 days.
Do not use in children under 12 years of age without medical advice.
Children from 6 to 12 years old: 1 tablet no more than 4 times a day; the drug can be used only in the case of a child's body weight of more than 20 kg. The interval between taking tablets for at least 6 hours (daily dose of not more than 30 mg / kg).
Side effects
Gastrointestinal tract (GIT): NSAIDs-gastropathy (abdominal pain, nausea, vomiting, heartburn, decreased appetite, diarrhea, flatulence, constipation; rarely - ulceration of the gastrointestinal mucosa, which in some cases are complicated by perforation and bleeding); irritation or dryness of the oral mucosa, pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis, pancreatitis.
Hepato-biliary system: hepatitis.
Respiratory system: shortness of breath, bronchospasm.
Sensory organs: hearing impairment: hearing loss, ringing or tinnitus; visual impairment: toxic damage to the optic nerve, blurred vision or double vision, scotoma, dryness and irritation of the eyes, paediatric of the conjunctiva and eyelids (allergic genesis).
Central and peripheral nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rarely - aseptic meningitis (more often in patients with autoimmune diseases).
The Brufen system: heart failure, tachycardia, increased blood pressure.
Urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
Allergic reactions: skin rash (usually erythematous or urticaria), pruritus, Quincke's edema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis, erythema necrolysis, (syndrome) allergic rhinitis.
Hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.
Other: sweating enhancement.
The risk of ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (color vision disorders, scotomas, amblyopia) increases with prolonged use in large Brufen
- bleeding time (may increase);
- serum glucose concentration (may decrease);
- creatinine clearance (may decrease);
- hematocrit or hemoglobin (may decrease);
- serum creatinine concentration (may Brufen
- activity of “liver” transaminases (may increase).
If side effects occur, stop taking the drug and consult a doctor.
Overdose
Symptoms abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, paediatric acidosis, coma, acute renal failure, decreased blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory arrest.
Treatment: gastric lavage (only within 1 hour after administration), activated carbon, alkaline drink, forced diuresis, symptomatic therapy.
Drug interaction
Concomitant use of ibuprofen with acetylsalicylic acid and other NSAIDs is not recommended. With the simultaneous administration of ibuprofen, it reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (it is possible to increase the Brufen of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an related link agent after starting ibuprofen). When prescribed with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding increases at the same time. Concomitant use with serotonin reuptake inhibitors (citalopram, fluoxetine, paroxetine, sertraline) increases the risk of serious gastrointestinal bleeding.