Interactions
Angiotensin II Receptor Blockers: Trimethoprim may enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. Monitor therapy
MiFEPRIStone: May increase the serum concentration of CYP2C9 Substrates (High risk with Inhibitors). Management: Use CYP2C9 substrates at the lowest recommended dose, and monitor closely for adverse effects, during and in the 2 weeks following mifepristone treatment. Consider therapy modification
Methotrexate: Trimethoprim may enhance the adverse/toxic effect of Methotrexate. Management: Consider avoiding concomitant use of methotrexate and either sulfamethoxazole or trimethoprim. If used concomitantly, monitor for the development of signs and symptoms of methotrexate toxicity (e.g., bone marrow suppression). Consider therapy modification
Food interaction
Take on empty stomach: 1 hour before or 2 hours after meals.
Take with a full glass of water.
Do not take calcium, aluminium, magnesium or iron supplements within 2 hours of taking this medication.
Overview
Hypersensitivity, renal failure, megaloblastic anemia due to folic acid deficiency, folic acid deficiency, pregnancy, lactation.
Carefully. Hepatic failure, bronchial asthma, thyroid dysfunction, early childhood.
Category of action on the fetus. C
Dosage
It is not used independently. It is used in combination with sulfanilamides (including with sulfamethoxazole - co-trimoxazole).
Side effects
Aseptic meningitis, methemoglobinemia, inhibition of bone marrow hematopoiesis (agranulocytosis, leukopenia, thrombocytopenia, anemia), malignant exudative erythema (Stevens-Johnson syndrome), diarrhea, decreased appetite, nausea or vomiting, nephropathy, peptic ulcer, gastral.
Overdose. Symptoms: folic additionally deficiency, bone marrow depression.
Treatment: gastric lavage, acidification of urine to enhance excretion of the drug by the kidneys, hemodialysis, calcium folinate - 3-6 mg / day this list m for 5-7 days or longer (until the normalization of hematopoiesis).
Interaction
Suppresses hepatic metabolism of phenytoin, increasing its T1 / 2 by 50% and reducing its clearance by 30%.
It reduces the renal clearance of procainamide and its metabolite N-acetyl-p-aminophenol, increasing their concentration in plasma. Enhances excretion and shortens T1 / 2 rifampicin. Enhances the anticoagulant effect of warfarin by inhibiting its metabolism.
The combination with sulfamethoxazole mutually enhances the antimicrobial effect (bactericidal effect).
Myelotoxic drugs - increased risk of inhibition of bone marrow hematopoiesis.
Cyclosporin - the frequency of nephrotoxicity increases. With simultaneous use with dapsone, concentrations of dapsone may increase (the frequency and severity of side effects, especially methemoglobinemia, may increase), and trimethoprim, which may be associated with a suppression of dapsone metabolism and / or competition of 2 drugs for excretion by the kidneys.
Dr. folic acid antagonists (methotrexate, pyrimethamine) increase the risk of megaloblastic anemia.
special instructions
With prolonged treatment, studies of peripheral blood, the functional state of the liver and kidneys should be systematically carried out. Elderly patients are shown the additional appointment of folic acid.
general information
About the drug:
Trimethoprim - an antibacterial drug.
Indications and dosage:
Overdose:
Exceeding the recommended dose of the drug Trimethoprim is manifested by nausea, dizziness, visual impairment and central nervous system, diarrhea, vomiting. With a significant overdose of Trimethoprim, anuria, crystalluria and the presence of blood in the urine can be observed. Chronic overdose can disrupt the process of folic acid production and provoke inhibition of the hematopoietic system (leukopenia, thrombocytopenia).
Side effects:
The use of trimethoprim can cause side effects - headache, allergic reactions to the skin (rash, itching, swelling, urticaria), nausea, lack of appetite, epigastric pain, diarrhea. In more severe cases, drug treatment may be complicated by aseptic meningitis, malignant exudative erythema, vomiting, anorexia, nephropathy. With the help of laboratory studies in the treatment of trimethoprim, methemoglobinemia, leukopenia, anemia, agranulocytosis, thrombocytopenia can be detected.
Brotrimsulp
It is not recommended to use the drug for allergies to the components of the product. Trimethoprim is categorically contraindicated for the treatment of young children - up to 1 year. The medication is contraindicated in severe pathologies of the liver and kidneys, folic acid deficiency and anemia caused by vitamin B9 deficiency. With caution, the drug is used in the treatment of patients suffering from bronchial asthma, hepatic pathologies, malfunctioning of the thyroid gland.
Interaction with other medicines and alcohol:
Trimethoprim is recommended to be taken together with sulfamethoxazole to enhance the pharmaceutical effect of both drugs and increase bactericidal properties. Drugs, a side effect of which is a toxic effect on the nervous system, increase the intensity of the effect on the bone marrow of Trimethoprim. Cyclosporine when taken with trimethoprim increases the likelihood of nephrotoxic complications. Taking dapsone during treatment with Trimethoprim can lead to an increase in the concentration of both drugs in the body. Slow elimination is due to the functional inability of the kidneys to excrete a double dose of antimicrobial agents from the body. Combined treatment with both drugs increases the risk of developing severe side effects. Drugs for the treatment of neoplasms, medicines for the prevention and treatment of Brotrimsulp, anticonvulsants and other drugs that inhibit the synthesis of folic acid, while used with Trimethoprim, increase the possibility of complications in the form of megaloblastic anemia. The drug slows the elimination of procainamide by the kidneys and, at the same time, increases its concentration in the patient's body. Trimethoprim together Brotrimsulp rifampicin accelerates its metabolism and the time of pharmaceutical exposure by half. Slowing down the metabolism of warfarin anticoagulants, Trimethoprim enhances its effect.
Composition and properties:
Trimethoprim is a white crystalline powder, insoluble in water and sparingly soluble in alcohol. The substance is part of the combined preparations of Biseptol, Bactrim, Bi-Septin, Dvaseptol, Co-Trimoxazole, Metosulfabol.
Trimethoprim is available in the form of combined tablets of 20 or 100 mg of active substance in each.
Trimethoprim refers to drugs with antibacterial action. The medication is effectively used to inhibit the reproduction, migration and growth of gram-negative (Proteus, Escherichia coli, Klebsiella) and a small number of gram-positive microorganisms - pathogens of bacterial infections. Trimethoprim, when ingested, inhibits dihydrofolate reductase during the synthesis of folic acid.
