Aminophylline may also be used for purposes not listed in this medication guide.
Brolin is a drug made in Bangladesh, Pakistan. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Aminophylline is a complete analogue of Brolin. It has the same composition, dosage and methods of use. Also Aminophylline has a lower cost compared to Brolin.
To buy Brolin, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
The incidence of adverse reactions is derived from treatment-related events as identified by the study investigators. seizures vomiting increased or rapid heart rate irregular heartbeat diarrhea stomach pain upset stomach skin rash
Warnings
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.
Tell your doctor if you smoke or have recently stopped smoking. Smoking can affect your aminophylline dose needs.
You should not be treated with this medicine if you are allergic to aminophylline or theophylline.
Interactions
Iohexol: Agents With Seizure Threshold Lowering Potential may enhance the adverse/toxic effect of Iohexol. Specifically, the risk for seizures may be increased. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iohexol. Wait at least 24 hours after the procedure to resume such agents. In nonelective procedures, consider use of prophylactic anticonvulsants. Consider therapy modification
Allopurinol: May increase the serum concentration of Theophylline Derivatives. Monitor therapy
Isoniazid: May increase the serum concentration of Theophylline Derivatives. Monitor therapy
Food interaction
Take with food.
Vitamin B6 needs increased, supplement recommended.
Limit caffeine intake.
Pregnancy
- While prospective studies of its use in pregnant women have failed to demonstrate an excess risk of congenital abnormalities, it remains the recommendation that alternatives are used in women trying to conceive or in those at higher risk of unplanned pregnancy.
- Some research has linked the use of Zofran during pregnancy to cleft palates, according to a 2012 report in the journal Canadian Family Physician.
- This may increase your chances of becoming pregnant.
Overview
10 ml - ampoules (5) - contour plastic packaging (1) - packs of cardboard.
10 ml - ampoules (5) - contour plastic packaging (2) - packs of cardboard.
10 ml - ampoules (10) - contour plastic packaging (1) - packs of cardboard.
10 ml - ampoules (10) - contour plastic packaging (2) - packs of cardboard.
pharmachologic effect
Bronchodilator, PDE inhibitor. It is theophylline ethylenediamine salt (which facilitates solubility and increases absorption). It has a bronchodilating effect, apparently due to a direct relaxing effect on the smooth muscles of the respiratory tract and blood vessels of the lungs. It is believed that this action is caused by selective suppression of the activity of specific PDE, which leads to an increase in the intracellular concentration of cAMP. The results of experimental in vitro studies show that the isozymes of types III and IV seem to play the main role. Suppression of the activity of these isoenzymes can also cause some side effects of aminophylline (theophylline), including vomiting, arterial hypotension, and tachycardia. Blocks adenosine (purine) receptors, which may be one of the factors affecting the bronchi.
Reduces airway hyperreactivity associated with the late phase of the reaction caused by inhalation of allergens through an unknown mechanism that does not apply to PDE inhibition or to block the action of adenosine. There are reports that aminophylline increases the number and activity of T-suppressors in peripheral blood.
Increases mucociliary clearance, stimulates diaphragm contraction, improves respiratory and intercostal muscle function, stimulates the respiratory center, increases its sensitivity to carbon dioxide and improves alveolar ventilation, which ultimately leads to a decrease in the severity and frequency of apnea episodes. Normalizing respiratory function, it helps to saturate the blood with oxygen and reduce the concentration of carbon dioxide. Enhances ventilation in hypokalemia.
It has a stimulating effect on heart activity, increases strength and heart rate, increases coronary blood flow and increases myocardial oxygen demand. Reduces the tone of blood vessels (mainly the vessels of the brain, skin and kidneys). It has a peripheral venodilating effect, reduces pulmonary vascular resistance, lowers blood pressure in the pulmonary circulation. Increases renal blood flow, has a moderate diuretic effect. Extends extrahepatic biliary tract. Stabilizes mast cell membranes, inhibits the release of mediators of allergic reactions. It inhibits platelet aggregation (suppresses platelet activating factor and PgE 2α), increases the resistance of red blood cells to deformation (improves the rheological properties of blood), reduces thrombosis and normalizes microcirculation. It has a tocolytic effect, increases the acidity of gastric juice. In high doses, has an epileptogenic effect.
Pharmacokinetics
In the body, aminophylline is metabolized at physiological pH values with the release of free theophylline. Bronchodilating properties are manifested when theophylline concentrations in blood plasma are 10-20 μg / ml. Concentrations above 20 mg / ml are toxic. The exciting effect on the respiratory center is realized at a lower concentration of 5-10 μg / ml.
The binding of theophylline Brolin plasma proteins is approximately 40%; in newborns, as well as in adults with diseases, binding is reduced. Plasma protein binding in adults is about 60%, in newborns - 36%, in patients with cirrhosis - 36%. Penetrates through the placental barrier (the concentration in the blood serum of the fetus is slightly higher than in the mother's serum). Excreted in breast milk.
Theophylline is metabolized in the liver by several cytochrome P450 isoenzymes, the most important of which is CYP1A2. In the process of metabolism, 1,3-dimethyl uric acid, 1-methyl uric acid and 3-methylxanthine are formed. These Brolin are excreted in the urine. Unchanged in adults, 10% is excreted. In newborns, a significant part is excreted in the form of caffeine (due to the immaturity Brolin the pathways of its further metabolism), unchanged - 50%.
Significant individual differences in the rate of hepatic metabolism of theophylline are the cause of the pronounced variability of the values of clearance, plasma concentration, half-life. Hepatic metabolism is influenced by factors such as age, addiction to tobacco smoking, diet, diseases, and concomitant drug therapy.
T 1/2 theophylline in non-smoking patients with bronchial asthma with practically Brolin pathological changes from other organs and systems is 6-12 hours, in smokers - 4-5 hours, in children - 1-5 hours, in newborns and premature babies - 10 -45 h.
T 1/2 theophylline increases in the elderly and in patients with heart failure or liver disease.
Ground clearance decreases with heart failure, impaired liver function, chronic alcoholism, pulmonary edema, COPD.
Ethylenediamine does not affect theophylline pharmacokinetics.
Attention! This medication may be especially undesirable to interact with alcohol! More details.
Indications for use
For parenteral administration: asthmatic status (additional therapy), neonatal apnea, ischemic type of cerebrovascular accident (as part of combination therapy), left ventricular failure with bronchospasm and Cheyne-Stokes type of respiratory failure, edematous https://zentherapycenter.com/let-x/xyzal-allergy.php syndrome (as part of complex therapy).
For oral administration: bronchial obstructive syndrome of any genesis: bronchial asthma (the drug of choice in patients with physical activity asthma and as an additional remedy for other forms), COPD (pulmonary emphysema, chronic obstructive bronchitis), hypertension in the pulmonary circulation, pulmonary "heart, night apnea.
Possible analogues (substitutes)
Active substance, group
