Overview
Allergic reactions: urticaria, chills or fever, rash, itching; rarely - bronchospasm, eosinophilia, exudative erythema multiforme (including Stevens-Johnson syndrome), serum sickness, anaphylactic shock.
From the digestive system: nausea, vomiting, diarrhea or constipation, flatulence, abdominal pain, taste disorder, stomatitis, glossitis, pseudomembranous enterocolitis, impaired liver function (increased activity of hepatic transaminases, less commonly - alkaline phosphatase or bilirubin, cholestatic jaundice) ("Sludge" syndrome), dysbiosis.
From the hemopoietic system: anemia, leukopenia, leukocytosis, neutropenia, granulocytopenia, lymphopenia, thrombocytosis, thrombocytopenia, hemolytic anemia, hypocoagulation, a decrease in the concentration of flame coagulation factors (II, VII, IX, X), prolongation of prothrombin time.
From the urinary system: impaired renal function (azotemia, increased blood medicated, hypercreatininemia, glucosuria, cylindruria, hematuria), oliguria, anuria.
Local reactions: phlebitis, soreness along the vein, soreness and infiltration at the site of intramuscular injection.
Other: headache, dizziness, nosebleeds, candidiasis, superinfection.
Ceftriaxone - Special Instructions
With simultaneous severe renal and hepatic failure, in patients undergoing hemodialysis, the plasma concentration of the drug should be regularly determined.
With prolonged treatment, it is necessary to regularly monitor the picture of peripheral blood, indicators of the functional state of the liver and kidneys.
In rare cases, with ultrasound of the gallbladder, blackouts are noted that disappear after stopping treatment (even if this phenomenon is accompanied by pain in the right hypochondrium, it is recommended that antibiotic administration and symptomatic treatment be continued).
During treatment, you should not drink alcohol, since disulfiram-like effects are possible (facial flushing, spasm in the abdomen and stomach, nausea, vomiting, headache, decreased blood pressure, tachycardia, shortness of breath).
Despite a detailed history taking, which is the rule for other cephalosporin antibiotics, it is impossible to exclude the possibility of developing anaphylactic Broadced, which Broadced immediate treatment - first injected iv with epinephrine, then GCS.
In vitro studies have shown that, like other cephalosporin antibiotics, ceftriaxone is able to displace bilirubin bound to serum albumin. Therefore, in newborns with hyperbilirubinemia, and especially in premature infants, the use of ceftriaxone requires even greater caution.
Elderly and debilitated patients may need vitamin K.
Store the prepared solution at room temperature for no more than 6 hours or in the refrigerator at a temperature of 2-8 ° C for no more than 24 hours.
With impaired renal function
With caution, a drug is prescribed for impaired renal function.
With simultaneous severe renal and hepatic failure, in patients undergoing hemodialysis, the plasma concentration of the drug should be regularly determined.
With prolonged treatment, it is choice to regularly monitor indicators of the functional state of the kidneys.
With impaired liver function
With simultaneous severe renal and hepatic failure, in patients undergoing hemodialysis, the plasma concentration of the drug should be regularly determined.
With prolonged treatment, it is necessary to regularly monitor indicators of the functional state of the liver.
In rare cases, with ultrasound of the gallbladder, blackouts are noted that disappear after stopping treatment (even if this phenomenon is accompanied by demonstrate in the right hypochondrium, it is recommended that antibiotic administration and symptomatic treatment be simple
Ceftriaxone - Precautions
With a combination of renal and hepatic insufficiency, dose adjustment and plasma concentration monitoring are required (blood levels are recommended to be periodically monitored for isolated impaired liver or kidney function).
