Interactions
Beta-Blockers: Nonsteroidal Anti-Inflammatory Agents may diminish the antihypertensive effect of Beta-Blockers. Exceptions: Levobunolol; Metipranolol. Monitor therapy
Quinolones: Nonsteroidal Anti-Inflammatory Agents may enhance the neuroexcitatory and/or seizure-potentiating effect of Quinolones. Nonsteroidal Anti-Inflammatory Agents may increase the serum concentration of Quinolones. Monitor therapy
Herbs (Anticoagulant/Antiplatelet Properties) (eg, Alfalfa, Anise, Bilberry): May enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents. Bleeding may occur. Management: Concomitant treatment with these agents should generally be avoided. If used concomitantly, increased diligence in monitoring for adverse effects (eg, bleeding, bruising, altered mental status due to CNS bleeds) must be employed. Consider therapy modification
Food interaction
Take with food to reduce gastric irritation.
Avoid alcohol
Food delays the time to reach peak plasma concentrations by 30-60 minutes and reduces peak plasma concentrations by 30-50%. Extent of absorption is unaffected.
Overview
Carefully. Elderly, heart failure, arterial hypertension, coronary heart disease, cerebrovascular disease, dyslipidemia, diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol consumption, liver cirrhosis with portal hypertension, liver and / or renal failure with creatinine clearance less than 60 ml / min, nephrotic syndrome, hyperbilirubinemia, gastric and duodenal ulcer (history), the presence of H. pylori infection, gastritis, enteritis, colitis, blood diseases unclear etiology (leukopenia and anemia), lactation, prolonged use of NSAIDs, severe somatic diseases, concomitant use of oral GCS (including prednisone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline).
Dosage
Ibuprofen is prescribed adults and children over 12 years old inside, in tablets of 200 mg 3-4 times a day. To achieve a quick therapeutic effect, the dose can be increased to 400 mg (2 tablets) 3 times a day. When the Boschofen effect is achieved, the daily dose of the drug is reduced to 600-800 mg. The morning dose is taken before meals with a sufficient amount of water (for faster absorption of the drug). The remaining doses are taken throughout the day after eating.
The maximum daily dose is 1200 mg (do not take more than 6 tablets in 24 hours). Take a repeated dose no more than 4 hours later. Duration of use of the drug without consulting a doctor is no more than 5 days.
Do not use in look under 12 years of age without medical advice.
Children from 6 to 12 years old: 1 tablet no more than 4 times a day; the drug can be used only in the case of a child's body weight of https://zentherapycenter.com/let-w/wilko-15-long-lasting-flea-collar.php than 20 kg. The interval between taking tablets for at least 6 hours (daily dose of not more than 30 mg / kg).
Side effects
Gastrointestinal tract (GIT): NSAIDs-gastropathy (abdominal pain, nausea, vomiting, heartburn, decreased appetite, diarrhea, flatulence, constipation; rarely - ulceration of the gastrointestinal mucosa, which in some cases are complicated by perforation and bleeding); irritation or dryness of the oral mucosa, pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis, pancreatitis.
Hepato-biliary system: hepatitis.
Respiratory system: shortness of breath, bronchospasm.
Sensory organs: hearing impairment: hearing loss, ringing or tinnitus; visual impairment: toxic damage to the optic nerve, blurred vision or double vision, scotoma, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic genesis).
Central and peripheral nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rarely - Boschofen meningitis (more often in patients with autoimmune diseases).
The cardiovascular system: heart failure, tachycardia, increased blood pressure.
Urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
Allergic reactions: skin rash (usually erythematous or urticaria), pruritus, Quincke's edema, anaphylactoid reactions, anaphylactic Boschofen, bronchospasm or dyspnea, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis, erythema necrolysis, (syndrome) allergic rhinitis.
Hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.
Other: sweating enhancement.
The risk of ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (color vision disorders, scotomas, amblyopia) increases with prolonged use in large doses.
- bleeding time (may increase);
