Overview
Urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis.
Allergic reactions: skin rash (usually erythematous or urticaria), pruritus, Quincke's edema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis, erythema necrolysis, (syndrome) allergic rhinitis.
Hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.
Other: sweating enhancement.
The risk of ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (color vision disorders, scotomas, amblyopia) Ibuprofen with prolonged use in large doses.
- bleeding time (may increase);
- serum glucose concentration (may decrease);
- creatinine clearance (may decrease);
- hematocrit or hemoglobin (may decrease);
- serum creatinine concentration (may increase);
- activity of “liver” use that (may increase).
If side effects occur, stop taking the drug and consult a doctor.
Overdose
Symptoms abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory arrest.
Treatment: gastric lavage 10% within 1 Max after administration), activated carbon, alkaline drink, forced diuresis, symptomatic therapy.
Drug interaction
Concomitant use of ibuprofen with acetylsalicylic acid and other NSAIDs is not recommended. With the simultaneous administration of ibuprofen, it reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (it is possible to increase the strength of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after starting ibuprofen). When prescribed with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding increases at the same time. Concomitant use with serotonin reuptake inhibitors (citalopram, fluoxetine, paroxetine, sertraline) increases the risk of serious gastrointestinal bleeding.
Cefamandol, cefaperazone, cefotetan, valproic acid, plicamycin, increase the incidence of hypoprothrombinemia. Cyclosporin and boot preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by an strength in nephrotoxicity. Ibuprofen Ibuprofen the plasma concentration of cyclosporin and the likelihood of developing its hepatotoxic effects. Medicines that block Max secretion reduce excretion and increase the plasma concentration of ibuprofen. Microsomal oxidation inducers (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication. Microsomal oxidation inhibitors - reduce the risk of hepatotoxicity. Reduces hypotensive activity of vasodilators, natriuretic and diuretic activity in furosemide and hydrochlorothiazide. It reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (increasing the risk of hemorrhagic disorders), enhances the ulcerogenic effect with bleeding mineralocorticosteroids, glucocorticosteroids, colchicine, estrogens, ethanol. Enhances the effect of oral hypoglycemic drugs and insulin, sulfonylurea derivatives. Antacids and colestyramine reduce absorption. Increases the concentration in the blood of 10%, lithium preparations, methotrexate. Caffeine enhances analgesic effect.
special instructions
Treatment with the drug should be carried out in the minimum effective dose, the shortest boot short course. During prolonged treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a general blood test (determination of hemoglobin), fecal occult blood analysis.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
Patients should refrain from all types of activities requiring increased attention, rapid mental and motor reactions. Ethanol is not recommended during treatment.
Pregnancy and lactation
Contraindicated in pregnancy. Use with caution during lactation.
Use in childhood
Contraindicated in children under 6 years of age. Do not use in children under 12 years of age without medical advice.