Alendronate is also used to treat Paget's disease of bone.
Bonate is a drug made in Pakistan. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Alendronate is a complete analogue of Bonate. It has the same composition, dosage and methods of use. Also Alendronate has a lower cost compared to Bonate.
To buy Bonate, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Use the medicine exactly as directed. severe heartburn, burning pain in your upper stomach, or coughing up blood; diarrhea trouble breathing nausea stomach pain, nausea; bloody stools, diarrhea, constipation; or rash or hives
Warnings
This medicine may cause jaw bone problems (osteonecrosis). The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Ask your doctor about your own risk.
Interactions
Parathyroid Hormone: Alendronate may diminish the therapeutic effect of Parathyroid Hormone. More specifically, Alendronate may interfere with normalization of blood calcium concentrations. Avoid combination
Nonsteroidal Anti-Inflammatory Agents: May enhance the adverse/toxic effect of Bisphosphonate Derivatives. Both an increased risk of gastrointestinal ulceration and an increased risk of nephrotoxicity are of concern. Monitor therapy
Aminoglycosides: May enhance the hypocalcemic effect of Bisphosphonate Derivatives. Monitor therapy
Food interaction
Pregnancy
- This combination should be avoided in pregnant women.
- This drug can be passed on to your newborn while breastfeeding and may harm your baby.
- During pregnancy, Myambutol should be used only when prescribed.
Overview
Description
Round tablets, biconvex, from white to almost white (dosage of 10 mg).
Tablets are oval, biconvex, from white to almost white, with an extruded inscription "I" on one side and "29" on the include side (dosage 70 mg).
Pharmacotherapeutic group
Preparations for the treatment of bone diseases. Drugs that affect bone structure and mineralization. Bisphosphonates. Alendronic acid
ATX Code M05BA04
Pharmacological properties
Pharmacokinetics
After a single dose of the drug in a dose of 5-70 mg in the morning on an empty stomach 2 hours before breakfast, the bioavailability is 0.64%. With an interval of 1 hour or 30 minutes between taking the medicine and food, the absorption of alendronic acid decreases and its bioavailability is 0.46-0.39%. However, a decrease in absorption does not significantly affect the effectiveness of the drug. The simultaneous intake of coffee or orange juice reduces bioavailability by 60%.
Communication with plasma proteins is approximately 78%.
After ingestion, alendronic acid is temporarily distributed in the soft tissues, then is quickly incorporated into Bonate bone tissue and excreted in the urine.
When administered orally after 6 hours, the plasma concentration of alendronic acid decreases by more than 95%. The elimination half-life is approximately 10 years, which indicates a long-term elimination of alendronic acid from bone tissue. Absorbed, but not integrated into the bone tissue, alendronic acid is rapidly excreted in the urine. Alendronic acid is not excreted by either the acid or alkaline transport systems of the kidneys: sodium alendronate probably does not affect the excretion of drugs by the above systems.
Despite the lack of evidence, kidney disease may decrease the excretion of sodium alendronate, followed by an increase in deposition in bone tissue. In the feces, the active substance is Bonate detected. There is no data confirming the metabolism of sodium alendronate in the human body.
Pharmacodynamics
Sodium alendronate is a bisphosphanate, an analogue of pyrophosphate that binds bone hydroxyapatite. The mechanism of action is associated with the suppression of bone resorption by osteoclasts without a direct effect on bone formation. Progressively increases bone mineral density (regulates calcium-phosphorus metabolism). The use of sodium alendronate promotes the formation of bone tissue of normal composition and structure.
Indications for use