Order Bonate in Internet

Name	Bonate
Active ingredient	Alendronate
Category
Dosage
Availability	In Stock

Buy Bonate (Alendronate)

Bonate is used to treat or relieve symptoms of the following diseases: ,

Alendronate is also used to treat Paget's disease of bone.

Bonate is a drug made in Pakistan. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.

Alendronate is a complete analogue of Bonate. It has the same composition, dosage and methods of use. Also Alendronate has a lower cost compared to Bonate.

Can You Buy Generic Bonate

To buy Bonate, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.

Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.

You can also use a coupon giving a 5% discount.

Side effects

Use the medicine exactly as directed. severe heartburn, burning pain in your upper stomach, or coughing up blood; diarrhea trouble breathing nausea stomach pain, nausea; bloody stools, diarrhea, constipation; or rash or hives

Warnings

This medicine may cause jaw bone problems (osteonecrosis). The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Ask your doctor about your own risk.

Interactions

Parathyroid Hormone: Alendronate may diminish the therapeutic effect of Parathyroid Hormone. More specifically, Alendronate may interfere with normalization of blood calcium concentrations. Avoid combination

Nonsteroidal Anti-Inflammatory Agents: May enhance the adverse/toxic effect of Bisphosphonate Derivatives. Both an increased risk of gastrointestinal ulceration and an increased risk of nephrotoxicity are of concern. Monitor therapy

Aminoglycosides: May enhance the hypocalcemic effect of Bisphosphonate Derivatives. Monitor therapy

Food interaction

Pregnancy

This combination should be avoided in pregnant women.
This drug can be passed on to your newborn while breastfeeding and may harm your baby.
During pregnancy, Myambutol should be used only when prescribed.

Overview

Description

Round tablets, biconvex, from white to almost white (dosage of 10 mg).

Tablets are oval, biconvex, from white to almost white, with an extruded inscription "I" on one side and "29" on the include side (dosage 70 mg).

Pharmacotherapeutic group

Preparations for the treatment of bone diseases. Drugs that affect bone structure and mineralization. Bisphosphonates. Alendronic acid

ATX Code M05BA04

Pharmacological properties

Pharmacokinetics

After a single dose of the drug in a dose of 5-70 mg in the morning on an empty stomach 2 hours before breakfast, the bioavailability is 0.64%. With an interval of 1 hour or 30 minutes between taking the medicine and food, the absorption of alendronic acid decreases and its bioavailability is 0.46-0.39%. However, a decrease in absorption does not significantly affect the effectiveness of the drug. The simultaneous intake of coffee or orange juice reduces bioavailability by 60%.

Communication with plasma proteins is approximately 78%.

After ingestion, alendronic acid is temporarily distributed in the soft tissues, then is quickly incorporated into Bonate bone tissue and excreted in the urine.

When administered orally after 6 hours, the plasma concentration of alendronic acid decreases by more than 95%. The elimination half-life is approximately 10 years, which indicates a long-term elimination of alendronic acid from bone tissue. Absorbed, but not integrated into the bone tissue, alendronic acid is rapidly excreted in the urine. Alendronic acid is not excreted by either the acid or alkaline transport systems of the kidneys: sodium alendronate probably does not affect the excretion of drugs by the above systems.

Despite the lack of evidence, kidney disease may decrease the excretion of sodium alendronate, followed by an increase in deposition in bone tissue. In the feces, the active substance is Bonate detected. There is no data confirming the metabolism of sodium alendronate in the human body.

Pharmacodynamics

Sodium alendronate is a bisphosphanate, an analogue of pyrophosphate that binds bone hydroxyapatite. The mechanism of action is associated with the suppression of bone resorption by osteoclasts without a direct effect on bone formation. Progressively increases bone mineral density (regulates calcium-phosphorus metabolism). The use of sodium alendronate promotes the formation of bone tissue of normal composition and structure.

Indications for use

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Review

For Prevention of Osteoporosis: "I was in pretty good shape working out 3 to 4 days a week, never really having any bone problems. My doctor prescribed Alendronate sodium for me supposedly to prevent osteoporosis because I am taking prednisone. I took it twice as instructed. By that night I felt some pains. Through the night it got worse, but figured it would settle down. OMG !! That next day , I felt like a can that was being crushed. I felt like I was going to be paralyzed from my right arm, through my hip , in my groin area, and my right shin and leg was numb and still is. My right side still hurts after 5 months or more. Spent a whole day in the emergency room where the same doctor was on duty. The doctor tried to say it seemed like it was my back nerve. Barely gave me anything for the pain. I stay in pain. I need a attorney about this because my insurance will not pay for an MRI . AND Though it's not as bad I believe it has caused permanent damage "