Rosiglitazone is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Rosiglitazone is not for treating type 1 diabetes.
Blutab is a drug made in Pakistan. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Rosiglitazone is a complete analogue of Blutab. It has the same composition, dosage and methods of use. Also Rosiglitazone has a lower cost compared to Blutab.
To buy Blutab, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Severe adverse reactions reported in the study included dark urine, yellowing of eyes or skin, fast or pounding heartbeat, headache; or persistent nausea or vomiting, stomach or abdominal pain, or changes in your vision; or changes in menstrual cycles,
Warnings
Rosiglitazone is not approved for use by anyone younger than 18 years old.
Rosiglitazone may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.
Interactions
RifAMPin: May increase the metabolism of Thiazolidinediones. Management: Consider alternatives to the concomitant use of rifampin with thiazolidinedione antidiabetic agents. Monitor patients receiving these combinations for decreased effects of the thiazolidinedione derivative. Consider therapy modification
MiFEPRIStone: May increase the serum concentration of CYP2C8 Substrates (High risk with Inhibitors). Management: Use CYP2C8 substrates at the lowest recommended dose, and monitor closely for adverse effects (including myopathy), during and in the 2 weeks following mifepristone treatment. Consider therapy modification
Atazanavir: May increase the serum concentration of Rosiglitazone. Monitor therapy
Food interaction
Pregnancy
- Make sure your doctor knows if you miss your period 2 months in a row, because this could mean that you are pregnant.
- You are pregnant, planning to become pregnant or you are not using an effective contraceptive.
Overview
Latin name
Pharmacological group
Hypoglycemic synthetic and other open this link
Characterization of the substance
Pharmacology
Is a selective agonist of nuclear receptors Blutab (peroxisome proliferator-activated receptor-gamma). In humans, these receptors are located in the “target tissues” that are essential for insulin action: in adipose tissue, in skeletal muscle and liver. PPARγ nuclear receptors regulate the transcription of insulin-responsive genes involved in the control of glucose production, transport and utilization. In addition, PPARγ-sensitive genes are involved in the metabolism of fatty acids.
Rosiglitazone lowers blood glucose, increasing the sensitivity of insulin receptors in adipose tissue, skeletal muscle and liver. Reduces circulating insulin, inhibits liver gluconeogenesis.
A feature that characterizes the pathogenesis of type 2 diabetes is insulin resistance. The hypoglycemic effect of rosiglitazone was studied in laboratory animals on Blutab model of type 2 diabetes mellitus, in which hyperglycemia and / or impaired glucose tolerance were a consequence of the target tissue insulin resistance. It was found that rosiglitazone reduces the concentration of glucose in the blood and the level of hyperinsulinemia in mice with the ob / ob genotype (obesity), in mice with the db / db genotype (diabetes) and in Zucker rats with the genotype fa / fa (obesity). In laboratory animals, the antidiabetic effect of rosiglitazone was manifested by an increase in insulin sensitivity of liver cells, striated muscles and adipose tissue. The release of insulin-dependent specific glucose transporter GLUT − 4 increased in adipose tissue. Rosiglitazone did not cause hypoglycemia and decrease glucose tolerance in laboratory animals with type 2 diabetes.
Application
According to the Physicians Desk Reference (2009), rosiglitazone maleate is indicated for improving glycemic control in patients with type 2 diabetes mellitus as an addition to diet and exercise (as monotherapy or in combination with sulfonamide and / or metformin).
Rosiglitazone: Contraindications
Hypersensitivity, established heart failure III and IV class according to NYHA.
Pregnancy and lactation
Rosiglitazone: Side Effects
According to double-blind clinical trials in patients who were on monotherapy with rosiglitazone maleate (n = 2526) compared with placebo (n = 601), the following side effects were most often observed (in brackets,% occurrence in the placebo group): upper respiratory tract infections 9.9% (8.7), trauma 7.6% Blutab, headache 5.9% (5.0), lower back pain 4.0% (3.8), hyperglycemia 3.9 % (5.7), fatigue 3.6% (5.0), sinusitis 3.2% (4.5); diarrhea 2.3% (3.3), hypoglycemia 0.6% (0.2).
