Amlodipine is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.
Blooms the Chemist Perindopril Arginine/Amlodipine is a drug made in Australia. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Amlodipine is a complete analogue of Blooms the Chemist Perindopril Arginine/Amlodipine. It has the same composition, dosage and methods of use. Also Amlodipine has a lower cost compared to Blooms the Chemist Perindopril Arginine/Amlodipine.
To buy Blooms the Chemist Perindopril Arginine/Amlodipine, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Get emergency medical help if you have even mild symptoms: dizziness very fast heart rate lightheadedness inflamed muscle or tissue blockages in your arteries and veins nausea upper body discomfort hives
Warnings
To make sure amlodipine is safe for you, tell your doctor if you have:
- liver disease; or
- a heart valve problem called aortic stenosis.
Amlodipine is not approved for use by anyone younger than 6 years old.
Amlodipine can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding.
Interactions
Dabrafenib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Management: Seek alternatives to the CYP3A4 substrate when possible. If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely (particularly therapeutic effects). Consider therapy modification
Antifungal Agents (Azole Derivatives, Systemic): May enhance the adverse/toxic effect of Calcium Channel Blockers. Specifically, itraconazole may enhance the negative inotropic effects of verapamil or diltiazem. Antifungal Agents (Azole Derivatives, Systemic) may decrease the metabolism of Calcium Channel Blockers. Fluconazole and isavuconazonium likely exert weaker effects than other azoles and are addressed in separate monographs. Management: Concurrent use of felodipine or nisoldipine with itraconazole is specifically contraindicated. Frequent monitoring is warranted with any such combination; calcium channel blocker dose reductions may be required. Exceptions: Fluconazole; Isavuconazonium Sulfate. Consider therapy modification
Diazoxide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy
Food interaction
Take without regard to meals.
Avoid natural licorice.
Grapefruit down regulates post-translational expression of CYP3A4, the major metabolizing enzyme of amlodipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of amlodipine and may cause toxicity. Avoid grapefruit products while on this medication.
Pregnancy
- It should not be used in pregnancy, particularly during the first trimester.
- Wort have liver problems have kidney problems have heart problems have or had seizures or convulsions have bipolar disorder or mania have low sodium levels in your blood have a history of a stroke have high blood pressure have or had bleeding problems are pregnant or plan to become pregnant.
Overview
Inhibitors CYP3A4: the combined use of amlodipine bloom strong CYP3A4 inhibitors (protease inhibitors, antifungal azoles, macrolides such as erythromycin or clarithromycin, verapamil or diltiazem) can significantly enhance the effects of amlodipine. The clinical consequences of these pharmacokinetic interactions may be more pronounced in elderly patients. If necessary, clinical monitoring and dose adjustment should be performed.
Inductors CYP3A4: chemists on the effect of CYP3A4 inducers on amlodipine are not available. The combined use of CYP3A4 inducers (for chemist, such as rifampicin, St. John's wort (St. John's wort preparations), can reduce the plasma concentration of amlodipine. The should be used with caution in conjunction with CYP3A4 inducers.
The combined use of amlodipine with grapefruit or grapefruit juice is not recommended, since the bioavailability of Arginine/Amlodipine and, accordingly, its hypotensive effect may increase.
Dantrolene (parenteral): In animal experiments after the administration of verapamil and dantrolene, the development of fatal ventricular fibrillation and cardiovascular failure due to hyperkalemia was observed intravenously. Due to the risk of hyperkalemia, it is recommended to avoid the simultaneous administration of calcium channel blockers, such as amlodipine, to patients at risk of developing malignant hyperthermia or Arginine/Amlodipine those receiving treatment for malignant hyperthermia.
The effect of amlodipine on bloom drugs
Amlodipine enhances the antihypertensive effect of other antihypertensive drugs. In clinical studies of interactions, amlodipine did not affect the chemist of atorvastatin, cyclosporine.
Simvastatin: combined repeated use of amlodipine at a dose of 10 mg with simvastatin at a dose of 80 Perindopril led to an increase in the effect of simvastatin by 77% compared with monotherapy with simvastatin. It is recommended that the dose of simvastatin be limited to 20 mg daily in patients receiving amlodipine.
Precautionary measures
During treatment, it is necessary to control body weight and be observed by the dentist (to prevent soreness, bleeding and gingival hyperplasia). Amlodipine does not affect plasma concentrations of Perindopril +, glucose, TG, total cholesterol, LDL, uric acid, creatinine and urea nitrogen. Abrupt withdrawal of the drug should be avoided because of the risk of worsening Arginine/Amlodipine bloom of angina pectoris. Amlodipine tablets are not recommended for hypertensive bloom. Women of childbearing age should use reliable methods of read more during treatment.
The composition of the drug the lactose, and therefore it is not recommended for use in patients with rare congenital galactose intolerance, Lapp lactase deficiency and glucose-galactose malabsorption.
Heart failure patients
In patients with heart failure, amlodipine should be used with the
In a placebo-controlled long-term study in patients with severe heart failure of non-ischemic etiology (NYHA class III and IV) who took amlodipine, the incidence of pulmonary edema was higher Perindopril in the placebo group. Arginine/Amlodipine channel blockers, including amlodipine, should be used with caution in patients with chronic heart failure, as they increase the chemist of future cardiovascular complications and mortality.
Children. No experience with children.
Fertility. In some patients who received treatment with calcium channel blockers, reversible sperm changes were observed. Clinical evidence of potential effects of amlodipine on fertility is relatively insufficient.
One study in rats Perindopril side effects on male fertility.
Impact on the ability to drive vehicles and other potentially dangerous mechanisms. Patients taking amlodipine may develop dizziness, headache, symptoms of fatigue or nausea, so care should be taken during the treatment period when driving vehicles and engaging in potentially dangerous activities that high doses an increased concentration of attention and speed of psychomotor reactions.
Instruction manual
Tradename
International Nonproprietary Name
Dosage form
