Bisoprolol is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins).
Bison is a drug made in Pakistan. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Bisoprolol is a complete analogue of Bison. It has the same composition, dosage and methods of use. Also Bisoprolol has a lower cost compared to Bison.
To buy Bison, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
No other new adverse reactions were identified. Tremors feeling dizzy disopyramide weakness quinidine Tremors propafenone metoprolol
Warnings
It is not known whether bisoprolol is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Interactions
EPINEPHrine (Systemic): Beta-Blockers (Beta1 Selective) may diminish the therapeutic effect of EPINEPHrine (Systemic). Monitor therapy
CYP3A4 Inducers (Strong): May increase the metabolism of CYP3A4 Substrates (High risk with Inducers). Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Consider therapy modification
Floctafenine: May enhance the adverse/toxic effect of Beta-Blockers. Avoid combination
Food interaction
Take without regard to meals.
Pregnancy
- Do not take Mevacor if you are pregnant.
- There is evidence of risk to the u nborn baby based on studies in humans or adverse reaction data, but this medication may be given to a pregnant woman only if her healthcare provider believes that its benefits to the pregnant woman outweigh any possible risks to her unborn baby.
Overview
Effect on the fetus: intrauterine growth retardation, hypoglycemia, bradycardia, respiratory distress (neonatal asphyxia) in newborns is also possible. If you need to take during lactation, breastfeeding must be stopped, since bisoprolol is excreted in breast milk.
special instructions
Bisoprolol is used bison caution in psoriasis (including indications of psoriasis in a family history), diabetes mellitus in the decompensation phase, and a predisposition to the development of allergic reactions. With pheochromocytoma, taking the drug is possible only after the use of alpha-blockers.
Before conducting bisons on taking the medicine, it for treating necessary to notify the anesthesiologist. The drug should be taken with caution in patients whose work is associated with the need for a high concentration of attention and the speed of psychomotor reactions.
Interaction
Invalid combinations with bisoprolol:
Not recommended combinations:
- with antihypertensive drugs, which are characterized by a central mechanism of action;
- with calcium antagonists;
- with MAO inhibitors (excluding MAO-B inhibitors).
- With caution, the drug is prescribed with:
- sympathomimetics;
- Amifostinum;
- cardiac glycosides (digitalis preparations);
- anticholinesterase drugs;
- non-steroidal anti-inflammatory drugs;
- antihypertensive drugs that increase the risk of hypotension (for example, tricyclic antidepressants, phenothiazines or barbiturates);
- sympathomimetics, which are characterized by the ability to activate β-adrenergic receptors;
- ergotamine derivatives;
- calcium antagonists, which belong to the group of dihydropyridine derivatives;
- Baclofen;
- anesthetics;
- insulin preparations and oral antidiabetic agents;
- parasympathomimetics;
- local blockers;
here drugs of class I and III.
Analogues of the drug Bisoprolol
The same active substance contains analogues:
- Biol.
- Corbis.
- Concor cor.
- Tyrese.
- Concor.
- Biprol.
- Bisoprolol-Prana (-Lugal, -Rathiopharm, -Teva).
- Cordinorm.
- Aritel.
- Bisomor.
- Bidop.
- Hypertin.
- Bioscard.
- Biscard.
- Bisogamma.
- Aritel Cor.
Similar effects have analogues:
- Betak.
- Nebilet.
- Betalok.
- Nebivolol.
- Breviblock.
- Lidalok.
- Atenolol.
- Serdol.
- Metoprolol Acry.
- Metocardium.
- Nebivator.
- Vero-Atenolol.
- Vasocardine.
- Metozok.
- Betacard.
- Cordanum.
- Lockren.
- Egilok.
- Nevotens.
Which is better - Bisoprolol or Concor?
Concor is a trademark under which the original bisoprolol is produced. The manufacturer of the drug is the German pharmaceutical company Merck KGaA. However, the patent for this medicine has long expired, so a large number of more affordable bisoprolol generics are currently available on the market.
It is believed that all of them are not inferior in quality to the original drug, however, official data that would confirm this is not enough today.
In pharmacies, the price of BISOPROLOL, 10 mg tablets (Moscow), is 65 rubles per pack of 30 pieces.
Bisoprolol
Structure
1 tablet 2.5 mg Active ingredient: bisoprolol fumarate 2.5 mg. 1 tablet 5.0 mg Active substances: bisoprolol fumarate 5.0 mg. 1 tablet 10.0 mg Active ingredients: bisoprolol fumarate 5.0 mg.
Pharmacotherapeutic group
ATX Code
pharmachologic effect
Bisoprolol is a selective β1-blocker, without its own sympathomimetic activity, does not have a membrane-stabilizing effect. As with other β1-blockers, the mechanism of action for arterial hypertension is unclear. At the same time, it is known that bisoprolol reduces plasma renin activity, reduces myocardial oxygen demand, and reduces heart rate (HR). It has antihypertensive, antiarrhythmic and antianginal effects. Blocking β1-adrenergic receptors of the heart in low doses, it reduces the formation of cyclic adenosine monophosphate (cAMP) stimulated by catecholamines from adenosine triphosphate (ATP), reduces the intracellular current of calcium ions, inhibits all cardiac functions, and reduces atrioventricular (AV) conductivity and excitability. When the therapeutic dose is exceeded, it has a β2-blocking effect. The total peripheral vascular resistance at the beginning of the use of the drug, in the first 24 hours, increases (as a result of a reciprocal increase in the activity of α-adrenergic receptors and elimination of stimulation of β2-adrenergic receptors), after 1-3 days it returns to its original value, and decreases with prolonged use. The antihypertensive effect is associated with a decrease in minute blood volume, sympathetic stimulation of peripheral vessels, a decrease in the activity of the sympathoadrenal system (CAS) (of great importance for patients with initial hypersecretion of renin), restoration of sensitivity in response to a bison in blood pressure (BP) and the effect on the central nervous system. With arterial hypertension, the effect develops after 2-5 days, a stable effect is observed after 1-2 months. The antianginal effect is due to a decrease in myocardial oxygen demand as a result of a decrease in contractility and other myocardial functions, lengthening of diastole, and improvement of myocardial perfusion. By increasing the final diastolic pressure in the left ventricle and increasing the stretching of the muscle fibers of the ventricles, oxygen demand may increase, especially in patients with chronic heart failure (CHF). When used in medium therapeutic doses, unlike non-selective β-blockers, it has a less pronounced effect on organs containing β2-adrenergic receptors (pancreas, skeletal muscle, smooth muscles of the peripheral arteries, bronchi and uterus) and on carbohydrate metabolism; does not cause sodium ion retention in the body; the severity of the atherogenic effect does not differ from the action of propranolol.
