Quetiapine is used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old.
Biquelle XL is a drug made in United Kingdom. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Quetiapine is a complete analogue of Biquelle XL. It has the same composition, dosage and methods of use. Also Quetiapine has a lower cost compared to Biquelle XL.
To buy Biquelle XL, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
No other new adverse reactions were identified. Agitation Fast Heartbeat Feeling Weak Muscle Problems That Cause Abnormal Movement Loss Of Memory Stuffy Nose Inflammation Of The Nose Diabetic Ketoac >If experienced, these tend to have a Less Severe expression
Warnings
You should not breast-feed while you are using quetiapine.
Interactions
Buprenorphine: CNS Depressants may enhance the CNS depressant effect of Buprenorphine. Management: Consider reduced doses of other CNS depressants, and avoiding such drugs in patients at high risk of buprenorphine overuse/self-injection. Initiate buprenorphine at lower doses in patients already receiving CNS depressants. Consider therapy modification
Fosaprepitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Monitor therapy
Anticholinergic Agents: May enhance the adverse/toxic effect of other Anticholinergic Agents. Monitor therapy
Food interaction
Take without regard to meals.
Avoid alcohol.
Pregnancy
- It is believed that if the egg is fertilized, these hormones are influential in the prevention of further egg release until the pregnancy has terminated.
- Hormonal contraceptives should not be used as the sole method to prevent pregnancy in patients receiving bosentan.
Overview
health properties
“Quetiapine” refers to atypical antipsychotics, its active substance is quetiapine. The dosage of the tablets may be as follows: 25, 100, 150, 200 mg. When ingested, quetiapine begins to interact with receptors located in the brain:
- 5-HT2 serotonin (predominantly);
- D1- and D2-dopamine;
- alpha1- and alpha2-adrenergic receptors;
- histamine.
The duration of the connection of the active substance with D2 and 5-HT2 receptors is at least 12 hours. Standard tests show antipsychotic activity of the drug. The drug effectively affects both positive and negative manifestations of schizophrenia.
Pharmacokinetics
When it enters the body, the drug is well absorbed from the digestive tract, undergoing metabolism in the liver. About 83% of quetiapine binds to plasma proteins. Eating does using this particularly affect the biological activity of the drug.
The elimination half-life is about 7 hours. The substance is excreted from the body naturally (as part of urine and feces) mainly in the form of metabolites. Only a small fraction comes out unchanged.
In which cases "Quetiapine" is prescribed
Quetiapine is used according to the following indications:
- psychoses (in acute, chronic form);
- schizophrenia, including hebephrenic;
- manic episode in the structure of bipolar affective disorder (BAR);
- depressive episode of moderate, severe severity in the structure of the BAR;
- major depressive disorder.
Keep in mind that Quetiapine is not intended to prevent the development of manic, depressive episodes.
Contraindications to the appointment of "Quetiapine"
Quetiapine is contraindicated in medicine following cases:
- hypersensitivity to the drug;
- simultaneous use of CYP3A4 inhibitors (antifungal drugs, HIV protease inhibitors, as well as Erythromycin, Clarithromycin, Nefazodon);
- age up to 18 l .;
- breast-feeding.
With caution, he is prescribed:
- To old Biquelle
- pregnant women;
- people suffering from cerebrovascular, cardiovascular diseases or other conditions that may be accompanied by arterial hypotension;
- with convulsive seizures in the medical history;
- with liver failure.
How to take Quetiapine
Quetiapine is taken orally, regardless of food intake. Dose and frequency of use depend on the disease. Consider how to use the drug for one or another indication.
Therapy of schizophrenia, psychosis
During the first 4 days, the daily dosage of Quetiapine will be as follows:
- in the first 24 hours - 50 mg;
- on the 2nd day - 100 mg;
- on the 3rd day - 200 mg;
- on the 4th day - 300 mg.
In the future, the daily this is selected until the necessary therapeutic effect is achieved. As a rule, the therapeutic dose is 300-450 mg (per day) and can vary from 150 mg to 750 mg / day. (depending on the results of therapy). The daily amount should not exceed 750 mg. In the treatment of schizophrenia, psychosis, the medicine should be drunk 2 r. / Day.
Bipolar disorder therapy
For patients with a manic episode in the structure of bipolar Biquelle, the daily amount of Quetiapine in the first 4 days of treatment will be as follows:
- 1 day - 100 mg;
- 2 day - 200 mg;
- 3 day - 300 mg;
- 4 day - 400 mg.
By day 6, the amount of the drug can be increased to 800 mg (per day). Keep in mind that you can increase the dose by no more than 200 mg / day. On average, to achieve a therapeutic effect, it will take 400-800 mg / day. The dose depends on the severity of the condition, individual tolerance of the drug. The daily amount should not be higher than 800 mg. The medicine is taken 2 p. / Day.
To stop a depressive episode in the structure of the Quetiapine BAR, you need to drink 1 r. / Day (at night). The treatment regimen in the first four days:
