Nifedipine is used to treat hypertension (high blood pressure) and angina (chest pain).
Bio-Nifedipine is a drug made in South Africa. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Nifedipine is a complete analogue of Bio-Nifedipine. It has the same composition, dosage and methods of use. Also Nifedipine has a lower cost compared to Bio-Nifedipine.
To buy Bio-Nifedipine, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Careful monitoring by your doctor may decrease your risk. nelfinavir rash or hives nelfinavir trouble swallowing fainting muscle cramps weakness swelling of the face, eyes, lips, or tongue
Warnings
To make sure nifedipine is safe for you, tell your doctor if you have:
- severe COPD (chronic obstructive pulmonary disease);
- kidney disease;
- congestive heart failure; or
- if you take other medications, especially an antibiotic or antifungal medicine, an antidepressant, heart or blood pressure medicine, or drugs to treat HIV/AIDS or hepatitis C.
The nifedipine extended-release tablet may contain lactose. Talk to your doctor before using this form of nifedipine if you have galactose intolerance, or severe problems with lactose (milk sugar).
You should not use this medicine if you are allergic to nifedipine, if you have severe coronary artery disease, or if you have had a heart attack within the past 2 weeks.
Interactions
Nafcillin: May decrease the serum concentration of NIFEdipine. Consider therapy modification
FLUoxetine: May enhance the adverse/toxic effect of NIFEdipine. Monitor therapy
Dexmethylphenidate: May diminish the therapeutic effect of Antihypertensive Agents. Monitor therapy
Food interaction
Take with low fat meal.
Avoid alcohol.
Avoid natural licorice.
Grapefruit down-regulates post-translational expression of CYP3A4, the major metabolizing enzyme of nifedipine. Grapefruit, in all forms (e.g. whole fruit, juice and rind), can significantly increase serum levels of nifedipine and may cause toxicity. Avoid grapefruit products while on this medication.
Pregnancy
- You are currently pregnant or you plan to become pregnant.
- Your healthcare provider may switch you to insulin injections some time during your pregnancy.
- This medication is not recommended for use during pregnancy due to the risk for harm to an unborn baby.
Overview
- Arterial hypertension (as a single drug or in combination with other antihypertensive drugs).
- Angina pectoris of rest and tension (including variant) with coronary heart disease.
At what pressure is prescribed?
Nifedipine is a fairly strong drug that is taken at high pressure (during surges) from 150 to 110 mm Hg.
Instructions for use (at what pressure to take)
Nifedipine pills or tablets
The dosage regimen is set individually, depending on the severity of the disease and the patient's response to the therapy. It is recommended to take the drug during or after meals with a little water.
Initial dose: 1 tablet (tablet) (10 mg) 2-3 times a day. If necessary, the dose can be increased to 2 tablets or dragees (20 mg) - 1-2 times a day. The maximum daily dose is 40 mg.
In elderly patients or patients receiving combination (antianginal or antihypertensive) therapy, as well as in case of impaired liver function, in patients with severe cerebrovascular accident, the dose should be reduced.
Retard tablets
Take inside. Tablets should be swallowed whole, without chewing, during or after a meal, with a small amount of water. The recommended dose of the drug is 20 mg 2 times a day. With insufficient severity of the effect, it is possible to increase the dose of the drug to 40 mg 2 times a day. The maximum daily dose is 80 mg.
In case of impaired liver function, the daily dose should not exceed 40 mg. In elderly patients or patients receiving combination (antianginal or antihypertensive) therapy, lower doses are usually prescribed. The duration of treatment is determined in each case individually.
Contraindications
Taking Nifedipine tablets is contraindicated in a number of pathological and physiological conditions of the body, which include:
- Arterial hypotension - a decrease in the level of systemic blood pressure, in which systolic blood pressure is less than 90 mm RT. st.
- Children under 18 years old.
- Idiopathic hypertrophic subaortic stenosis, in which the cause of the narrowing remains unclear.
- Hypersensitivity to nifedipine or auxiliary components of the drug.
- Stenosis (narrowing) of the mitral or aortic valve of the heart.
- Cardiogenic shock - acute and severe insufficiency of the pumping function of the heart, accompanied by vascular collapse.
- Pregnancy at any time during its course, breastfeeding.
- Severe increased heart rate (tachycardia).
- Acute myocardial infarction (death of a part of the heart muscle due to acute circulatory disorders in it) within 4 weeks.
- Sick sinus syndrome - functional failure of the atrial used treat
- Severe heart failure in the decompensation stage.
With caution, Nifedipine tablets are Bio-Nifedipine for chronic heart failure, a marked decrease in the functional activity of the liver and kidneys, severe circulatory disorders in the brain, diabetes mellitus, especially at the stage of decompensation, malignant arterial hypertension.
Also, with extreme caution, the drug is used in patients undergoing hemodialysis (hardware-based blood purification) due to the high risk of severe arterial hypotension. Before you start using Nifedipine tablets, make sure there are no contraindications.
Side effects
Treatment with the drug can cause the following side effects:
- From the digestive system: diarrhea, heartburn, nausea, deterioration of the liver; in some cases, gingival hyperplasia. With prolonged use of the drug in high doses, dyspeptic symptoms may occur, the development of intrahepatic cholestasis or an increase in the activity of hepatic transaminases.
- From the peripheral nervous system and central nervous system: headaches. With prolonged therapy in high doses, muscle pain, paresthesia, sleep disturbances, tremors, minor visual disturbances are possible.
- From the endocrine system: the development of gynecomastia.
- From the cardiovascular system: sensation of heat, hyperemia of the skin, peripheral edema, hypotension, tachycardia, asystole, ventricular tachycardia, increased angina attacks, bradycardia.
- From the urinary system: increased daily urine output, impaired renal function (with prolonged use at high dosages). From the hemopoietic system: extremely rarely - thrombocytopenia, leukopenia.
- Allergic reactions: rash on the skin.
When administered intravenously, the drug causes a burning sensation at the injection site. With intracoronary administration of the drug within a minute after the start of the infusion, hypotension may develop and Bio-Nifedipine heart rate may increase.
Children, during pregnancy and follow
According to the instructions, Nifedipine is contraindicated during pregnancy and lactation. gynecological practice, in some cases, the practice of prescribing the drug during pregnancy as a hypotensive agent when other drugs are ineffective.
It is also noted that Nifedipine during pregnancy helps reduce uterine tone, but the drug has not yet been widely used for this indication.
