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Warnings

Amoxicillin can pass into breast milk, but based on a small number of studies, it has not been shown to cause any harm to a baby. Tell your doctor if you are breast-feeding a baby.

You should not use amoxicillin if you are allergic to any penicillin antibiotic, such as ampicillin, dicloxacillin, oxacillin, penicillin, or ticarcillin.

Interactions

Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Use of this vaccine should be postponed until at least 3 days after cessation of antibacterial agents. Consider therapy modification

Mycophenolate: Penicillins may decrease serum concentrations of the active metabolite(s) of Mycophenolate. This effect appears to be the result of impaired enterohepatic recirculation. Monitor therapy

Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Avoid combination

Food interaction

Take without regard to meals.

Pregnancy

• If you are pregnant and have questions related to medication use during pregnancy, the Reprotox Toxicology Center is the most comprehensive and easiest to use resource on medication use during pregnancy.
• If an ongoing pregnancy is suspected, a further ultrasound scan may be required to evaluate its viability.
• Tell your healthcare provider if you are pregnant or planning to become pregnant.

Overview

During pregnancy and lactation

The instruction prohibits the use of amoxicillin during breastfeeding. When an antibiotic gets into milk, it can harm the baby. If treatment is necessary, feeding should be suspended. The use of the drug during pregnancy has its own characteristics. Penicillins cross the placenta and accumulate in it. The concentration of amoxicillin in amniotic fluid reaches 25-30 percent of the plasma level of a pregnant woman, which is a risk for fetal development.

There are a number of recommendations for the use of an antibiotic during pregnancy:

• use the drug only if indicated;
• the dose and regimen are determined by the doctor, taking into account the condition of the woman;
• drug treatment is permissible only in the second and third trimester, when a placenta is formed;
• requires monitoring by the doctor for the patient's condition;
• it is necessary to consider all contraindications for use.

Amoxicillin for children

High fever, weakening of the body by infections - a reason medical prescribing a child a drug. Amoxicillin for colds is given to children in the form of a suspension (see photo below). The medicine is prepared before use. Included is a measuring spoon containing 250 mg of active substance. The instruction prescribes:

• add water to the bottle with granules;
• shake the mixture;
• children under two years of age give 20 mg of medication per read more of body weight per day;
• at the age of two to five - the dose is 125 mg;
• from 5 to 10 years - the number doubles;
• older than ten - a suspension dose of up to 500 mg;
• in severe cases - up to 1 gram.

Drug Interactions

During the use of the antibacterial agent Amoxicillin, you should carefully consider the simultaneous use of other medicines. According to the instructions, interaction with drugs can give a variety of results. Observed effects:

• Amoxicillin enhances the absorption of digoxin;
• increases the Bindoclav of indirect anticoagulants;
• reduces prothrombin index;
• reduces the effect of estrogen-containing oral contraceptives;
• increases the toxicity of methotrexate;
• reduces vitamin K synthesis.

It must be taken into account - Amoxicillin has a bactericidal effect on propagating microorganisms, therefore, it should not be used in conjunction with bacteriostatic antimicrobial drugs - sulfonamides, tetracyclines. With simultaneous use:

• Glucosamine, laxatives, slow the absorption of Amoxicillin, and ascorbic acid increases;
• Rifampicin drowns out antibacterial properties;
• non-steroidal anti-inflammatory drugs increase antibiotic concentration.
• Allopurinol increases the risk of skin rash.

Alcohol interaction

According to the instructions, Amoxicillin tablets, capsules or suspension should not be used with alcohol. The simultaneous use causes antagonism - direct incompatibility, which is dangerous for the body, increases the risk of impaired renal function. The following points should be considered:

• an antibiotic in the blood can be up to a week;
• alcohol is eliminated from the body after about two days;
• not only simultaneous use is dangerous;
• it is necessary to take into account the period of elimination of antibiotic and alcohol.

Amoxicillin - side effects

With independent use, violation of dosage, improper course duration, side effects may occur. The instruction stipulates the occurrence of a reaction of the body to taking Amoxicillin. Side effects are observed:

• loss of appetite;
• violation of Bindoclav intestinal microflora;
• allergy;
• insomnia;
• itching
• dizziness;
• hives;
• stomach ache;
• diarrhea;
• nausea;
• erythematous rash;
• vomiting
• impaired liver function;
• anxiety;
• cramps
• conjunctivitis;
• impaired consciousness;
• joint pain.

Side effects can be observed in case of an overdose of the drug. The occurrence of:

• anaphylactic shock;
• hemolytic anemia;
• allergic vasculitis;
• hyperemia;
• candidiasis;
• fever
• cholestatic jaundice;
• dysbiosis;
• rhinitis;
• stomatitis;
• difficulty breathing;
• tachycardia;
• Quincke's edema;
• Depression
• eosinophilia;
• peripheral neuropathies;
• hepatitis A;
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• anorexia.

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