Bicalutamide may also be used for purposes not listed in this medication guide.
Bicalox is a drug made in Australia, Bosnia & Herzegowina, New Zealand, South Africa, Tunisia. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Bicalutamide is a complete analogue of Bicalox. It has the same composition, dosage and methods of use. Also Bicalutamide has a lower cost compared to Bicalox.
To buy Bicalox, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
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Side effects
Tell your doctor right away if you develop signs of kidney problems such as a change in the amount of urine. hair loss, breast swelling/tenderness/pain, fever, chills; pain in your back, pelvis, or stomach; nausea, gas, changes in the amount of urine, stomach upset,
Warnings
Bicalutamide should never be taken by a woman or a child.
Interactions
Choline C 11: Antiandrogens may diminish the therapeutic effect of Choline C 11. Monitor therapy
Indium 111 Capromab Pendetide: Antiandrogens may diminish the diagnostic effect of Indium 111 Capromab Pendetide. Avoid combination
Aminolevulinic Acid (Topical): Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid (Topical). Monitor therapy
Food interaction
Take without regard to meals, at the same time everyday.
Pregnancy
- May increase liver function test values in pregnant women.
- Pregnancy screening for women of childbearing potential must be performed.
- Because of the uncertainty regarding the human implications of these animal data, this drug should be used during pregnancy only if clearly needed.
Overview
Violations of the liver: with mild impairment of liver function, dose adjustment is not required. In patients with moderate and severe hepatic impairment, increased cumulation of Bilumida may be observed.
Side effects
gynecomastia (may persist even after discontinuation of therapy, especially in the case of taking the drug for a long time), soreness of the mammary glands, hot flashes;
hypersensitivity reactions, including angioedema and urticaria, interstitial pulmonary diseases; when using the drug in a daily dose of 150 mg, abdominal pain, dyspepsia, depression, hematuria
Bicalutamide
Structure
1 film-coated tablet contains the active substance: 1 tablet of 50 mg contains the active substance: bicalutamide - 50.0 mg; 1 tablet of 150 mg contains the active substance: bicalutamide - 150.0 mg.
Pharmacotherapeutic group
Antineoplastic, antiandrogen.
ATX Code
pharmachologic effect
Bicalutamide is a racemic mixture with non-steroidal antiandrogenic activity of predominantly (R) -enantiomer, does not have other endocrine activity. Bicalutamide binds to androgen receptors and, without activating gene expression, inhibits the stimulating effect of androgens on them. The result of this is a regression of neoplasms of the prostate gland. In some patients, discontinuation of the drug may lead to the development of a clinical withdrawal syndrome of antiandrogens. When using bicalutamide in a daily dose of 150 Bicalox daily for the treatment of patients with locally advanced (TZ-T4, any N, MO or any T, N +, MO) prostate cancer as monotherapy or adjuvant therapy, the risk of disease progression and bone metastases is significantly reduced. With locally advanced prostate cancer, there is a tendency to improve life expectancy with no signs of disease progression in groups of patients taking bicalutamide at a dose of 150 mg as monotherapy or adjuvant therapy compared to standard therapy (surgical treatment, radiation therapy). An increase in life expectancy is shown among patients with locally advanced prostate cancer who received bicalutamide at a dose of 150 mg as monotherapy and as an adjuvant treatment in combination with radiation therapy. After oral administration, bicalutamide is rapidly and completely absorbed from the gastrointestinal tract. Eating does not affect absorption. (S) -enantiomer is eliminated from the body much faster than (R) -enantiomer, the half-life (T1 prescribe 2) of the latter is about 7 days. With daily use of bicalutamide, the concentration of (R) enantiomer in blood plasma increases by about 10 times due to prolonged T1 / 2, which makes it possible to take the drug 1 time per day. When taking bicalutamide daily at a dose of 50 mg, the equilibrium concentration of the (Css) (R) -enantiomer in plasma is about 9 μg / ml, at a dose of 150 mg, approximately 22 μg / ml. At equilibrium, about 99% of all enantiomers circulating in the blood are the active (R) -enantiomer. The binding to plasma proteins is high (for the racemic mixture 96%, for the (R) enantiomer - 99.6%). Intensively metabolized in the liver (by oxidation and the formation of conjugates with glucuronic acid). Metabolites are excreted by the kidneys and intestines in approximately equal proportions. The average concentration of (R) -enantiomer in the semen of men who received the drug at a dose of 150 mg is 4.9 μg / ml. The pharmacokinetics of the (R) enantiomer are not affected by age, impaired renal function, mild to moderate impaired liver function. There is evidence that in patients with severely impaired liver function, the elimination of (R) -enantiomer from plasma slows down.
Indications for use
Bicalutamide 50.0 mg In combination with a GnRH analog (gonadotropin releasing hormone) or surgical castration to treat advanced prostate cancer. Bicalutamide 150.0 mg As monotherapy or adjuvant therapy in combination with radical prostatectomy or radiation therapy for patients with locally advanced prostate cancer (T3-T4, any N, M0; T1-T2, N +, 0.9% w/v Sodium Chloride B Braun. As monotherapy for the treatment of patients with locally advanced non-metastatic prostate cancer, when surgical castration or https://zentherapycenter.com/let-c/cefwell.php medical interventions are not acceptable or not applicable
Contraindications
Hypersensitivity to bicalutamide or other components of the drug; simultaneous administration with terfenadine, astemizole and cisapride; children's age, female.
Dosage and administration
Inside, regardless of the meal, drink plenty of fluids. For adults and older men, with advanced prostate cancer in combination with a GnRH analog or surgical castration, 50 mg once Bicalox day. Treatment with the drug must begin simultaneously with the start of taking GnRH analogue or surgical castration. For adults and older men, with locally advanced prostate cancer - 150 mg once a day. The drug should be taken for a long time, at least for 2 years. If signs of disease progression appear, the drug should be discontinued. Dose adjustment is not required in patients with impaired renal function, mild impaired liver function. In patients with moderate and severe hepatic impairment, increased accumulation of Propen may be observed.
Release form
50.0 mg and 150.0 mg film-coated tablets. On 10, 30 tablets in a blister strip packaging from a film of polyvinyl chloride and aluminum foil printed varnished. For 10, recommend, 30, 40, 50, 60 or 100 tablets in cans of polyethylene terephthalate. One jar or 1, 2, 3, 4, 5, 6, or 10 blister packs, together with instructions for use, are placed in a cardboard box (pack).
Instructions from the tablets Listel.Ru
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