Overview
According to the instructions and patient reviews, the drug Cefix, intended for the preparation of a suspension for Bexacim, has shown itself to be an effective tool in the treatment of ailments caused by bacterial infections. Side effects resulting from its use are associated with individual intolerance to the drug.
Farm action
3rd generation cephalosporin antibiotic for parenteral use. It acts bactericidal (disrupts the synthesis of the cell wall of microorganisms). It has a wide spectrum of action, which includes various aerobic and anaerobic gram-positive and gram-negative microorganisms, including Pseudomonas aeruginosa. Resistant to beta-lactamases of both gram-positive and gram-negative microorganisms. It is highly active against Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis (including strains producing beta-lactamases), Escherichia coli, Proteusella gibelis bacteria, oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter spp. (including Citrobacter diversus), Serratia marcescens. Pseudomonas spp., Acinetobacter spp., Some strains of Streptococcus, Enterococcus spp. (methicillin resistant strains), Listeria monocytogenes, Bacteroides fragilis, most of the strains of Staphylococcus, Enterobacter and Clostridium are resistant to cefixime.
Pharmacokinetics
When administered, bioavailability is 40-50%. Food increases the maximum absorption time by 0.8 hours. TCmax - 2-6 hours for tablets and suspension 400 mg / 5 ml and 2-5 hours for suspension 200 mg / 5 ml. Cmax after oral administration of 100, 200 and 400 mg - 1-1.3, 2-3 and 3.5-4.4 μg / ml, respectively. After taking the suspension, Cmax is 25-50% higher (due to the difference in bioavailability, it is not recommended to replace the suspension with tablets Bexacim treatment of otitis media). Cmax in the urine after administration in doses of information, 200 and 400 mg - 73, 107 and 164 μg / ml, respectively. High concentrations of the drug Bexacim for a long time in blood serum, bile, and urine. T1 / 2 - 3-4 hours, with renal failure - 6.4-11.5 hours. Distribution volume - 0.11 l / kg. Communication with plasma proteins - 65-70%. It is excreted by the kidneys unchanged - 50%, with bile - 10%.
Indications
Bacterial infections of the upper and lower respiratory tract (pharyngitis, tonsillitis, sinusitis, acute bronchitis and exacerbation of chronic bronchitis), urinary tract (uncomplicated);
otitis media,
uncomplicated gonorrhea of the urethra and cervix.
Contraindications
Hypersensitivity, including to penicillins, penicillamine, children's age (up to 6 months), lactation.
Carefully. Elderly, renal failure, colitis (history), pregnancy.
Category of action on the fetus. B
Dosage
Inside. In an average daily dose for adults and children over 12 years old with a body weight of more than 50 kg - 400 mg once a day or 200 mg 2 times a day.
The daily dose for children with body weight less than 50 kg is 3-9 mg / kg; if necessary, the dose can be increased to 12 mg / kg. Multiplicity of appointment for adults - 2 times; children - 2-3 times a day. The average duration of treatment is 7-10 days.
Children under 12 years of age are prescribed as a suspension, at a dose of 8 mg / kg once a day or 4 mg / kg every 12 hours.
For children aged 5-11 years, the daily dose of the suspension is 6-10 ml, aged 2-4 years - 5 ml, aged 6 months to 1 year - 2.5-4 ml. For diseases caused by Streptococcus pyogenes, the course of treatment is at least 10 days.
With uncomplicated gonorrhea of the urethra and cervix - 400 mg once.
In case of impaired renal function, the dose is set depending on the level of QC in serum: with QC of 21-60 ml / min or in patients on hemodialysis, the daily dose should be reduced by 25%; with CC of 20 ml / min or less, or in patients undergoing peritoneal dialysis, the daily dose should be reduced by 2 times. Method of suspension: turn the bottle over and shake the powder. Add 40 ml of chilled boiled water in 2 stages and shake until a homogeneous suspension is formed. After this, it is necessary to allow the suspension to settle for 5 minutes to ensure complete dissolution of the powder. Shake the prepared suspension well before use.
Side effects
Allergic reactions: urticaria, skin hyperemia, pruritus, genital itching, eosinophilia, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome). From the nervous system: headache, dizziness, tinnitus.
From the genitourinary system: vaginitis.
From the urinary system: impaired renal function, interstitial nephritis.
From the digestive system: nausea, vomiting, stomatitis, diarrhea, abdominal pain, constipation, pseudomembranous enterocolitis, dysbiosis, cholestasis; cholestatic jaundice.
Hematopoietic organs: pancytopenia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, bleeding.
Laboratory indicators: increased activity of hepatic transaminases and alkaline phosphatase, hyperbilirubinemia, increased urea nitrogen, hypercreatininemia, increased prothrombin time. Other: candidiasis, development of hypovitaminosis B, dyspnea.
Overdose. Treatment: gastric lavage. Hemodialysis and peritoneal dialysis are ineffective.
special instructions
Patients with a history of allergic reactions to penicillins may be hypersensitive to cephalosporin antibiotics. During treatment, a false positive direct Coombs reaction and a false positive urine reaction to ketonuria, glucose are possible.
In some diseases, antibiotics cannot be avoided. But only those drugs that are active against the microorganisms that caused it can cope with the disease.
The drug "Cefixime"
The drug is produced in the form of oblong tablets of a light orange color. The main active substance in it is cefixime. Tablets are drunk once a day (but on the recommendation of a doctor, the reception can be divided into 2 stages). In this case, the daily dose for most diseases Bexacim adults and children whose weight exceeds 50 kg should be 400 mg. Therapy is carried out 7-10 days.
Potential substitutes
All of these drugs have the same active substance. Therefore, the mechanism of action and effectiveness are the same for them. Moreover, speaking about the need to use cefixime, doctors often mean that you need to purchase any of the drugs with the indicated active substance. The patient may, on the advice of a pharmacist or doctor, choose the most suitable product for him at a cost. The main thing open link to see that cefixime is the active substance. The price of Supraks Solutab soluble tablets (pack of 7 pcs. 400 mg each) is about 970 rubles. And 6 capsules "Supraks" (each this 400 mg of cefixime) will cost 810 rubles.
Another analogue is cheaper - Pancef tablets. Pack of 10 can be bought for 700 rubles. And the granules of the same name for the preparation of a suspension cost 215 rubles. Ixim Lupine powder costs about 500 rubles.
The drug "Suprax"
