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Warnings

Bisoprolol is not approved for use by anyone younger than 18 years old.

You should not use bisoprolol if you you are allergic to it, or if you have a serious heart condition such as:

• "AV block";
• severe heart failure; or
• slow heartbeats that have caused you to faint.

To make sure bisoprolol is safe for you, tell your doctor if you have:

• congestive heart failure or other heart problems;
• coronary artery disease;
• circulation problems (such as Peripheral Vascular Disease or Raynaud's syndrome);
• asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;
• diabetes (taking bisoprolol can make it harder for you to tell when you have low blood sugar);
• liver or kidney disease;
• a thyroid disorder; or
• a history of allergies.

Interactions

Ivosidenib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Monitor therapy

Amphetamines: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Obinutuzumab: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Management: Consider temporarily withholding blood pressure lowering medications beginning 12 hours prior to obinutuzumab infusion and continuing until 1 hour after the end of the infusion. Consider therapy modification

Food interaction

Take without regard to meals.

Pregnancy

• This medication is used to prevent pregnancy.
• As with the majority of drugs, there is little published evidence of its safety in the early stages of human pregnancy, but in animal studies there was evidence of some harmful effects on the foetus at very high dose levels.
• If you are pregnant, prenatal care that includes tests for birth defects is recommended.

Overview

Release form and composition

Bisoprolol is available in film-coated tablets. They have a round biconvex shape and color from beige-yellow to beige. At break, the tablet is white or almost white.

The main active ingredient of the drug is bisoprolol fumarate (5 or 10 mg each, depending on the form of release). Auxiliary components: povidone, pregelatinized starch, croscarmellose sodium, talc, aerosil, lactose, microcrystalline cellulose and magnesium stearate. The film membrane contains titanium dioxide, polyethylene glycol 3350, opadra II, talc, dye iron oxide (II).

Tablets are packed in 10 pieces in blister using (three blisters in cardboard packs) and 30 additionally in polymer bottles, plastic cans and dark glass cans (one can or one bottle in a cardboard pack).

Indications for use

Bisoprolol tablets are prescribed for the prevention of angina attacks, as well as in the case of a persistent rise in blood pressure (arterial hypertension).

Contraindications

The use of bisoprolol in such diseases and conditions as:

• Collapse;
• Pulmonary edema;
• Shock (including cardiogenic);
• Chronic heart failure in the decompensating stage;
• Acute heart failure;
• Severe bradycardia;
• Syndrome weakness syndrome;
• Sinoatrial block
• AV block 2 and 3 degrees;
• Cardiomegaly (without symptoms of heart failure);
• Prinzmetal's angina pectoris;
• COPD (chronic obstructive pulmonary disease) and / or severe history of bronchial asthma;
• Arterial hypotension;
• Metabolic acidosis;
• Pheochromocytoma (without sharing with alpha-blockers);
• Raynaud's disease;
• Children's age up to 18 years;
• Hypersensitivity to bisoprolol and / or other beta-blockers.

With caution, the drug is prescribed for myasthenia gravis, diabetes Betacor, psoriasis, chronic renal failure, thyrotoxicosis, depression, 1st degree AV block, liver failure, as well as elderly patients.

Dosage and administration

According to the instructions, Bisoprolol is taken in the morning on an empty stomach. Do not chew the tablet, but swallow it whole.

The Betacor dose is 5 mg once a day. If necessary, increase it to 10 mg. However, the maximum daily dose should not exceed 20 mg.

In patients with severe impaired liver or kidney function, the maximum dose is 10 mg per day.