Etanercept may also be used for purposes not listed in this medication guide.
Benepali is a drug made in Belgium, Czech Republic, Denmark, Estonia, Greece, Iceland, Ireland, Lithuania, Netherlands, Norway, Poland, Portugal, Romania, Spain, Sweden, United Kingdom. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Etanercept is a complete analogue of Benepali. It has the same composition, dosage and methods of use. Also Etanercept has a lower cost compared to Benepali.
To buy Benepali, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
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Side effects
Call your doctor for medical advice about side effects. Fever Cough Dizziness Vision problems Heart failure Liver disease Excessive tiredness Loss of appetite
Warnings
Tell your doctor if you have ever had tuberculosis or if anyone in your household has tuberculosis. Also tell your doctor if you have recently traveled. Tuberculosis and some fungal infections are more common in certain parts of the world, and you may have been exposed during travel.
Using etanercept may increase your risk of developing certain types of cancer, including lymphoma. This has occurred mainly in children and teenagers using TNF-blockers. However, anyone with an inflammatory autoimmune disorder may have a higher risk of lymphoma. Talk with your doctor about your own risk.
Interactions
Siponimod: Immunosuppressants may enhance the immunosuppressive effect of Siponimod. Monitor therapy
Sipuleucel-T: Immunosuppressants may diminish the therapeutic effect of Sipuleucel-T. Management: Evaluate patients to see if it is medically appropriate to reduce or discontinue therapy with immunosuppressants prior to initiating sipuleucel-T therapy. Consider therapy modification
Tacrolimus (Topical): May enhance the adverse/toxic effect of Immunosuppressants. Avoid combination
Food interaction
Pregnancy
- Therefore this product is not recommended for use during pregnancy and lactation.
- In a fertility study in rats, marginal reduction in male fertility and pseudopregnancy, protracted periods of diestrus, increased precoital interval and reduced pregnancy rate were seen.
Overview
Etanercept does not affect the overall bioavailability of cardiac glycosides, namely digoxin. It is worth noting that the presence of digoxin in the patient’s blood led to a decrease in the bioavailability of etanercept, but with individual characteristics.
Storage
In order for the therapeutic effect of the drug not to be lost, it must be stored in the refrigerator at a temperature that will be in the range from 2 to 8 degrees.
To purchase the drug in a pharmacy, you must present to the pharmacist a prescription from the attending physician, in which the doses, frequency of administration, general course of therapy.
The average shelf life of drugs based on this substance is 24 months.
Analogs
The main drug whose constituent substance is etanercept is Enbrel, manufactured by the pharmaceutical company Pfizer.
The synonyms (analogues) of etanercept * (etanercept *) are presented, interchangeable in terms of their effects on the body, preparations containing one or more identical active substances. When choosing synonyms, consider not only their cost, but also the country of production and the reputation of the manufacturer.
Benepali of the drug - List of analogues and prices
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Description of the drug
Etanercept * (Etanercept *) - Immunosuppressant, TNFα inhibitor. It is a hybrid dimeric protein molecule consisting of a TNF receptor with a molecular weight of 75 kD, connected to the Fc fragment (CH2 and CH3 regions) of human IgG1. Produced using recombinant DNA technology on Chinese hamster ovary cells.
Etanercept is a competitive inhibitor of the binding of TNF to its receptors on the cell surface, and thus inhibits the biological activity of TNF. TNF and lymphotoxin are pro-angiogenic cytokines that bind to two clearly distinguishable TNF receptors on the cell surface: 55 kilodaltons (p55) and 75 kilodaltons (p75). Both TNF receptors are present in the body in membrane bound and free forms. Soluble TNF receptors regulate the biological activity of TNF.
The dimeric structure of the TNF receptor in the etanercept molecule ensures its higher affinity for TNFα, which in turn determines a more pronounced competitive inhibition of Allow activity compared to the monomeric soluble TNF receptor present in biological fluids. Etanercept is also able to modulate biological responses controlled by other biological active substances (cytokines, adhesive molecules or proteinases), which are induced or regulated under the influence of TNF.
Does not cause complement-mediated Benepali of murine T cells expressed TNF on Benepali cell surface. TNF is an endogenous cytokine that is involved in normal inflammatory and immune responses. TNF is a dominant cytokine in the process of inflammation in rheumatoid arthritis. An increase in TNF levels is also found in synovial fluid and psoriatic plaques in patients with psoriatic arthritis, in serum and synovial tissue in patients with ankylosing spondylitis. In psoriasis, infiltration by inflammatory cells, including T cells, leads to an increase in the level of TNF in psoriatic foci, compared with intact skin.
List of analogues
Information on the page checked by general practitioner Vasilieva E.I.
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