Overview
Active substance, group
Dosage form
granules for preparing a suspension for oral administration, capsules, lyophilisate for preparing a solution for intravenous and intramuscular administration, lyophilisate for preparing a solution for intramuscular administration, powder for preparing a solution
We often wonder: “Can a drug capsule be opened?”. The reasons may be different - reluctance or health to swallow the capsule, the need to reduce the dosage, mix with baby food for the child, etc. Read more.
Contraindications
Hypersensitivity to the drug (including other penicillins, cephalosporins, carbapenems), infectious mononucleosis, lymphocytic leukemia, liver failure, gastrointestinal diseases in the anamnesis (especially colitis associated with the use of antibiotics), lactation, children (up to 1 month ).
With caution. Bronchial asthma, hay fever and other allergic diseases, renal failure, a history of bleeding, pregnancy.
How to use: dosage and course of treatment
Inside, for adults - 0.25 g 4 times a day for 0.5-1 hours before meals with a small amount of water; if necessary, increase the dose to 3 g / day.
Infections of the digestive tract and organs of the genitourinary system: 0.5 g 4 times a day.
Listeriosis - in / m or in / in 50 mg / kg every 6 hours.
For infections of moderate severity, adults are given IM 0.25-0.5 g every 6-8 hours; in severe infections - 1-2 g 3-4 times a day or iv in 0.5 g every 6 hours.
With meningitis - 14 g / day; the frequency of administration is 6-8 times.
With gonococcal urethritis - inside 3.5 g once, or IM 0.5 g 2 times for one day; with gonorrhea uncomplicated urethritis - once 0.5 g.
Children with severe and moderate infections - IM 25-50 mg / kg 4 times a day; with meningitis, the daily dose is 100-200 mg / kg for 6-8 injections.
In case of mild infections in children, it is preferable to prescribe a drug in the form of a suspension.
Children over 4 years of age are prescribed 1-2 g / day; up to 1 year - based on 100 mg / kg; 1-4 years - 100-150 mg / kg; newborns from 1 month - 150 mg / kg. The daily dose is divided into 4-6 doses.
The duration of treatment depends on the severity of the disease (from 5-10 days to 2-3 weeks, and in chronic processes - for several months).
pharmachologic effect
Semisynthetic penicillin, broad-spectrum, bactericidal. Acid resistant. Suppresses bacterial cell wall synthesis.
It is active against gram-positive (alpha and beta hemolytic streptococci, Streptococcus pneumoniae, Staphylococcus spp., Bacillus anthracis, Clostridium spp., Moderately active against most enterococci, including Enterococcus faecalis), Listeria sppus., And gramophilus spp., And influenzae, Neisseria meningitidis, Proteus mirabilis, Yersinia multocida (formerly Pasteurella), many species of Salmonella spp., Shigella spp., Escherichia coli) because this, aerobic non-spore forming bacteria.
Ineffective against penicillinase-producing strains of Staphylococcus spp., All strains of Pseudomonas aeruginosa, most strains of Klebsiella spp. and Enterobacter spp.
Side effects
Allergic Be-Ampicil possible - itching and peeling of the skin, urticaria, rhinitis, conjunctivitis, angioedema, rarely - fever, arthralgia, eosinophilia, erythematous and maculopapular rash, exfoliative dermatitis, multiforme exudative Stephan's syndrome, erythema multiforme) reactions similar to serum sickness, in isolated cases - anaphylactic shock, non-allergic ampicillin rash, can disappear without drug withdrawal.
From the digestive system: dysbiosis, stomatitis, gastritis, dry mouth, taste change, abdominal pain, vomiting, nausea, diarrhea, stomatitis, Be-Ampicil, moderate increase in the activity of hepatic transaminases, pseudomembranous enterocolitis.
From the side of the central nervous system: headache, tremor, cramps (with high dose therapy).
Laboratory findings: leukopenia, neutropenia, thrombocytopenia, agranulocytosis, anemia.
Local reactions: Be-Ampicil at the injection site, infiltrates with i / m administration, phlebitis with i / v administration in large doses.
