Overview
Side effects
As a rule, they are not observed, however, in rare cases, there may be an individual reaction, as warned by instructions. The substance oxytetracycline hydrochloride for animals is easily administered and does not form an abscess at the injection site. At recommended doses, it is generally well tolerated. However, bay reactions and dysbiosis can be observed. Sensitive animals are prescribed adrenaline and antihistamines, calcium, and in some cases corticosteroids.
Contraindications
This is, first of all, hypersensitivity to tetracycline drugs. It is not recommended for use in cases of impaired heart and liver function, and is also not used during pregnancy. It is forbidden to prescribe simultaneously with penicillin. Otherwise, be sure to consult your doctor. The duration of the course and bay dosages depend on many factors, so the instructions should be taken only as fact-finding information. In parallel with the antibiotic, drugs are prescribed that help normalize the intestines and restore the microflora.
Instructions from the tablets Listel.Ru
Only the pessary current official instructions for the use of medicines! The instructions for medicines on our pessary are published unchanged, in which they are attached to the drugs.
DRUGS FOR PRESCRIPTION HOLIDAYS ARE APPOINTED TO THE PATIENT ONLY BY THE DOCTOR. THIS INSTRUCTION IS FOR MEDICAL WORKERS ONLY.
Description of the active substance Oxytetracycline / Oxytetracycline.
Formula: C22H24N2O9, chemical name: (4S, 4aR, 5S, 5aR, 6S, 12aS) -4- (dimethylamino) -3,5,6,10,11,12a-hexahydros-6-methyl-1,12-dioxo-1 4,4a, 5,5a, 6,12,12a-octahydrotetracin -2-carboxamide.
Pharmacological group: antimicrobial, antiparasitic and antihelminthic agents / antibiotics / tetracyclines.
Pharmachologic effect: antibacterial, bacteriostatic.
Pharmacological properties
Oxytetracycline acts bacteriostatically by inhibiting the synthesis of protein microorganisms. According to the spectrum of antimicrobial action, oxytetracycline is similar to tetracycline, but it is bay active with respect to a number of microorganisms. Oxytetracycline is active against anaerobic bacteria - Clostridium spp .; gram-negative bacteria - Bordetella pertussis, Neisseria gonorrhoeae, Enterobacter spp., Klebsiella spp., Escherichia coli, Shigella spp., Salmonella spp .; gram-positive aerobic bacteria - Streptococcus spp., Staphylococcus spp .; as well as Rickettsia spp., Mycoplasma spp., Chlamydia spp., Spirochaetaceae. Proteus spp., Pseudomonas aeruginosa, Serratia spp., Many strains of Bacteroides fragilis, Mycobacterium pessary, Enterococcus spp., Small viruses, and most fungi are resistant to oxytetracycline. When administered oxytetracycline is absorbed by approximately 58%. After eating, absorption decreases. The maximum concentration in the blood is reached after 2 to 4 hours. Oxytetracycline binds to plasma proteins by 35%. Oxytetracycline is rapidly distributed in many body fluids, including bile, pleural effusion, paranasal sinus secretion, ascites, synovial fluid, and gingival groove fluid (3–7 times higher in serum). Oxytetracycline accumulates in the liver, bones, spleen, teeth, and tumors. Oxytetracycline is excreted in breast milk, crosses the placental barrier. The volume of distribution of oxytetracycline is 0.9 - 1.9 l / kg. Oxytetracycline in the liver is slightly metabolized. The half-life of oxytetracycline is 6 - 10 hours, with anuria is 47 - 66 hours. Oxytetracycline is excreted mainly by the kidneys, less with bile into the intestine, where its partial reverse reabsorption occurs, which contributes to the prolonged circulation of oxytetracycline in the body (intestinal-hepatic circulation).
Indications
Infectious and inflammatory pathology caused by microorganisms sensitive to oxytetracycline, including pneumonia, pleural empyema, bronchitis, tonsillitis, pyelonephritis, cholecystitis, intestinal infections, endometritis, endocarditis, prostatitis, gonorrhea, syphilis, brucellosis, purulent soft tissue infections; blackheads; conjunctivitis, trachoma, blepharitis; prevention of postoperative infections.
