Overview
In the annotation to the drug it is indicated that it is administered intramuscularly or intravenously by a jet or drip method. Before use, it is imperative to make a skin test for sensitivity more cefotaxime. With the intramuscular route of administration, it is necessary to put a sample on lidocaine. The drug is not taken orally.
Adults and children whose body weight exceeds 50 kg, the drug is administered in a dosage of 1 g twice daily intravenously or intramuscularly at regular intervals. If necessary, the introduction of the drug can be increased up to 6 times a day.
The maximum daily dose should not exceed 12 g. For children whose weight is less than 50 kg, the dose is calculated according to the weight: 50-100 mg of the drug per 1 kg. The resulting daily dose is divided into 3-4 injections. In case of meningitis or other severe infection, the daily dose can be increased to 100-200 mg per kg, the required volume is administered 4-6 times.
How many days you can inject the drug, determines the attending physician taking into account the underlying disease, the general reaction of the body, associated pathologies. The minimum duration of treatment is 7 days. This rule does not apply to uncomplicated gonorrhea.
For the treatment of the acute form of gonorrhea, not burdened by complications, 1 g of the drug is prescribed intramuscularly once a day. Treatment of severe meningitis or meningoencephalitis will require the introduction of 2 g of the drug 3-4 times a day. High doses a prophylaxis from postoperative complications, 1 g is prescribed before the operation and the same three times a day after it. Women who will undergo a cesarean section are given intravenously 1 g of the drug at the time when a clamp is applied to the umbilical vein. Repeatedly 1 g of the drug is administered after 6-12 hours.
In the treatment of infectious and inflammatory processes localized in the urinary tract, the drug is prescribed in a dosage of 1 g 2-3 times a day. In the treatment of diseases of an infectious nature of moderate severity, 1-2 g of the drug is administered twice a day.
Cefotaxime is diluted in the following way: for intramuscular injection, sterile water, 1% lidocaine or Novocaine in a ratio of 1 g of the drug per 4 ml of liquid is required. The vial should be shaken vigorously until the particles of the drug are completely dissolved. The last two drugs are used for analgesic effect, since cefotaxime injections themselves are painful. The medicine should be administered deeply and slowly in 3-5 minutes.
For intravenous jet injections, 1 g of the drug should be diluted in Baxim ml of 0.9% sodium chloride or in a solution for injection. In the resulting liquid should not be suspended or foreign inclusions. For intravenous drip injections, 1 g of the drug is diluted in 50 ml of 5% glucose or sodium chloride solution. The drug is administered for an hour.
Possible adverse reactions
With intramuscular administration are possible pain, with intravenous - phlebitis. In addition, adverse reactions can occur from the digestive system. Is possible vomiting, nausea, glossitis, dry mouth, heartburn, belching, diarrhea, loss of appetite. Except them:
- hepatitis;
- pseudomembranous colitis;
- cholestatic jaundice;
- elevated AST and ALT.
From the respiratory system, the appearance of bronchospasm, swelling of the mucous membranes of the respiratory tract. There is a risk of impaired renal function, in women - thrush.
From the circulatory system may occur hypoproteinemia, hemolytic anemia, neuropenia, cardiac arrhythmia, tachycardia. Platelet count reduction and even cardiac arrest possible.
Do not rule out the appearance of allergic reactions: Quincke's edema, itching, an increase in the number of eonzophiles, urticaria, dermatitis, toxic epidermal necrolysis, anaphylactic shock.
In addition, local reactions may occur:
- pain along the vein;
- the appearance Baxim hematomas;
- vein puncture;
- the appearance of painful infiltrate at the injection site;
- at the injection site, the skin may turn red Baxim swell.
During the administration of the medicine, the patient may Baxim that he lacks air, a feeling of heat in his face, tachycardia, shortness of breath, chills. The appearance of such conditions must be notified to the doctor and stop using the drug.
If the recommended dose is exceeded or the calculation is incorrect, signs of an overdose of the drug may appear: encephalopathy, dysbiosis, allergies, impaired liver and kidney function. Demonstrate this case, therapy should be discontinued.
Interaction with other medicines
During therapy with aminoglycosides, “loop” diuretics nephrotoxicity of the drug increases, so such medications are not prescribed at the same time. If used during treatment antiplatelet agents can used NSAIDs, then the risk of bleeding increases.
Cefotaxime compatibility with diuretics, anticoagulants zero, since with such an interaction side effects from the kidneys are possible, blood coagulation is impaired.
Never mix Cefotaxime and other drugs in the same syringe. The only exceptions are lidocaine and Novocaine. When using Probenecid, the concentration of the active substance of the drug increases and its excretion slows down.
special instructions
