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Warnings

To make sure amikacin is safe for you, tell your doctor if you have:

• kidney disease;
• asthma or sulfite allergy;
• myasthenia gravis;
• a nerve-muscle disorder; or
• a nervous system disorder such as Parkinson's disease.

Do not use amikacin if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy during treatment.

Interactions

Nonsteroidal Anti-Inflammatory Agents: May decrease the excretion of Aminoglycosides. Data only in premature infants. Monitor therapy

Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Avoid combination

BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Monitor therapy

Food interaction

Pregnancy

• All triptans are considered Category C in pregnancy.
• Using this medicine while you are pregnant may cause serious unwanted effects in your newborn baby.

Overview

In accordance with the instructions, Amikacin should be stored in a well-ventilated, dry place, out of reach of children, with room temperature varying between 5-25 ° C. The drug is dispensed from pharmacies with a prescription, its shelf life, subject to all manufacturer's recommendations, is two years.

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Amikacin is an antibacterial drug with a wide range of actions. Available in powder form and injection.

Pharmacological action of amikacin

In accordance with the instructions, the active active ingredient of the drug is amikacin. Excipients of the solution are sodium metabisulfite, sodium citrate pentasesquihydrate, water for injection, sulfuric acid diluted.

According to the instructions, Amikacin is a semi-synthetic antibiotic belonging to the group of aminoglycosides. The drug prevents the formation of a complex of matrix and transport RNA due to the Bakacin of amikacin to the 30S subunit of ribosomes, dulls protein synthesis and has a devastating effect on the cytoplasmic membranes of bacteria.

When used, Amikacin is active against aerobic gram-negative microorganisms (Shigella spp., Serratia spp., Salmonella spp., Enterobacter spp., Escherichia Bakacin, Providencia spp., Klebsiella spp., Pseudomonas aeruginosa) and some gram-positive microorganisms, ( including penicillin resistant). The drug exhibits moderate activity against Streptococcus spp.

When combined with benzylpenicillin, the drug is highly effective in the treatment of infections with Enterococcus faecalis strains.

Many anaerobic microorganisms are resistant to amikacin.

Since the activity of the drug does not decrease when exposed to enzymes that inactivate other aminoglycosides, when used, Amikacin is active against strains of Pseudomonas aeruginosa that are resistant to netilmicin, gentamicin and tobramycin.

With intramuscular administration, Amikacin is rapidly and completely absorbed. The active substance practically does not bind to blood proteins, is well distributed in extracellular fluids, penetrates the placental barrier and is not metabolized. The period of complete elimination of the drug from the body of adults is 4-8 hours, of newborns - 10-16 hours, of the elderly - 5-8 hours. It is excreted unchanged by the kidneys.

Indications Amikacin

According to the instructions, Amikacin is prescribed for the treatment of infectious and inflammatory diseases:

• Respiratory tract: lung abscess, empyema, pleura, pneumonia, bronchitis;
• Central nervous system, including meningitis;
• Genitourinary tract: urethritis, pyelonephritis, cystitis;
• Abdominal cavity, including peritonitis;
• Biliary tract;
• Skin and soft tissues, including pressure sores, check, burns;
• Bones and joints.

Amikacin is effective for sepsis, wound infections, septic endocarditis and postoperative infections.

Dosage and administration of amikacin