Overview
Biseptol is a broad-spectrum antibiotic
Sulfamethoxazole and trimethoprim are included, as active substances, in the composition of the drug called Co-trimoxazole, which is a combined antibacterial drug with a wide spectrum of action. Used in medicine to kill bacteria that cause infections such as pneumonia, infections of the ears or urinary tract. This medicine Bacitran sometimes be prescribed for other purposes. It follow known as Biseptolum. The antibiotic, however, has many other trade names: Bactrim, Bi-sept-Farmak, Berlotsid, Bi-Septin, Bisutrim, Biseptrim, Bikotrim, Groseptol, Gene-Ultrazol, Disepton, Duo-Septol, Cotrimol, Cotrim-Rivofarm, Novo -Trimel, Kotrifarm, Oribact, Rankotrim, Oriprim, Septrin, Sulotrim, Sinersul, Sumerolim, Trimezol, Trim, Trimosul, Expozol, Including, Intrim .
A wide spectrum of bactericidal action is distinguished simple the drug Biseptol. The antibiotic is available in tablet form. The chemotherapeutic effect is due to two active substances. Sulfamethoxazole inhibits the PABA utilization process and disrupts the synthesis of dihydrofolic acid in bacterial cells, exerting a bacteriostatic effect. Trimethoprim is able to inhibit the enzyme involved in folic acid metabolism and convert dihydrofolate to tetrahydrofolate. As a result of the blocking of two successive ingredient of the biosynthesis of purines and nucleic acids, the conditions for the reproduction and growth of bacteria are violated. High concentrations of the drug are created in the tissues of the kidneys, lungs, prostate gland, bile, cerebrospinal fluid, in the bones.
Only as prescribed by the doctor should take Biseptolum. The antibiotic should not be taken along with other drugs, such as Phenytoin (Dilantin), Warfarin (Coumadin) and others. You must also inform your doctor if you are allergic to co-trimoxazole, diuretics, or diabetes medications. The patient must tell the doctor the history of his illness and report on kidney diseases, asthma. After all, only a doctor can evaluate the advisability of using the drug Biseptol in this case. Indications for its use should repeatedly outweigh the risk of possible negative consequences. Taking Biseptolum, you need to analyze any changes in the physical and moral state. If adverse reactions such as vomiting, loss of appetite, sore throat, fever, pallor are detected, you should immediately consult a doctor.
The patient should remember that immediate medical consultation is required in case of any questions that arose during the treatment with Biseptol. An antibiotic is characterized by the most common side effects - these are gastrointestinal upsets. Sulfamethoxazole may cause nausea, heaviness in the stomach, or abdominal pain. An allergy to sulfa drugs usually causes a rash on the skin, hives, trouble breathing or swallowing. In this case, you must immediately stop taking the medicine and contact your doctor. Sometimes when taking this medication, muscle pain occurs. If symptoms persist, contact a physician. If breathing problems or swelling of the face, mouth, tongue are noticed, then you need to stop treatment and get emergency medical care, as these reactions are often symptoms of a severe allergy.
Biseptol is an antibiotic whose main substances are sulfamethoxazole in combination with trimethoprim. They can cause megaloblastic anemia in some patients (they are caused by a deficiency of B12 or folic acid), because they are antagonists of this check. Clinical manifestations of this condition are associated with impaired functions of the nervous system and the entire blood system, as well as the gastrointestinal tract due to damage to the epithelium. Problems in the blood system are accompanied by anemic syndrome (weakness, fatigue, tachycardia, dyspnea with physical exertion, pallor of the mucous membranes and skin).
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When a doctor prescribes a drug such as Biseptol, especially for children (suspension), many are interested in the question - is Biseptol an antibiotic or not? Such drugs as nitroxoline, streptocid, phthalazole, biseptol, metronidazole, etc. are not antibiotics - they are antimicrobials. Their difference from true antibiotics is:
- origin
- mechanism of action on pathogenic microorganisms
- general effect on the body
- efficiency.
Antibiotics are drugs of semisynthetic or natural origin that have an antimicrobial effect, and Biseptol is a fully synthesized drug that belongs to the pharmacological group of sulfonamides, which were traditionally called antibacterial chemotherapy drugs.
Antibiotics kill bacteria or inhibit their growth and reproduction. Sulfanilamides are embedded in the structure of microorganisms instead of para-aminobenzoic acid, and disrupt metabolic processes, vital activity, growth and reproduction of bacteria. Despite the similarity of the mechanisms of action, Bacitran (biseptol) are not antibiotics. This is another group of antimicrobials.
Regranex are the first systemic antimicrobial agents. Their use over the
Warbex of 65 years has provoked the emergence of a mass of microbial strains that have become resistant to them. It was possible to increase the sensitivity of bacteria when creating combined preparations, combining these antimicrobial agents with trimethoprim - Co-trimoxazole (Biseptol analogues - suspension price 110 rubles, table 30-70 rubles, Bactrim - price 170 rubles, B-septin, Brifesptol, Dvaceptol, Duo -septol), as well as to this group include Sulfalen, Sulfadimethoxin, Sulfaethidol.
In some cases, when infectious diseases occur, the causative agents of which remain sensitive to the drugs of this group, Biseptolum is still prescribed, especially for urinary tract infections, and for the prevention of pneumocystis pneumonia against the background of AIDS.
Biseptol and other sulfonamides in recent years are not widely used in medical practice. The emergence of modern broad-spectrum antibiotics, the active use of fluoroquinolones, has led to the fact that the use of sulfonamides is significantly reduced.
Indications and contraindications for the use of Biseptol
Biseptol and its analogues are indicated for diseases when the sensitivity of pathogenic microorganisms to Co-trimoxazole is determined. Sulfanilamides inhibit the growth of some protozoa - toxoplasmosis, malaria, as well as gram-positive and gram-negative bacteria, chlamydia, therefore they are used for:
- ENT diseases - otitis media in children, sinusitis (see antibiotics for sinusitis)
- Infectious diseases of the genitourinary system, mild chancre, urethritis, pyelonephritis, cystitis (all tablets for cystitis), prostatitis (treatment of prostatitis with antibiotics), salpingo-oophoritis, gonorrhea
- Respiratory diseases - pneumocystis pneumonia, acute and chronic bronchitis, lung abscess
- Soft tissue and skin infections - pyoderma, furunculosis
- Toxoplasmosis - in complex therapy, osteomyelitis, acute brucellosis
- Infectious diseases of the digestive tract - travelers' diarrhea, dysentery (symptoms of dysentery), typhoid fever, cholera, paratyphoid
Biseptol and its analogues are contraindicated, with:
