Acyclovir is used to treat infections caused by herpes viruses, such as genital herpes, cold sores, shingles, and chicken pox, as well as varicella (chickenpox), and cytomegalovirus.
Avorax is a drug made in Hong Kong. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Acyclovir is a complete analogue of Avorax. It has the same composition, dosage and methods of use. Also Acyclovir has a lower cost compared to Avorax.
To buy Avorax, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
Use the medicine exactly as directed. Loss of consciousness Tiredness Diarrhea Muscle or joint aches Agitation Hair loss Loss of consciousness Confusion
Warnings
Acyclovir passes into breast milk, but is considered compatible with breast feeding. Tell your doctor if you are breast-feeding a baby while taking this medication.
Herpes can be passed to your baby during childbirth if you have a genital lesion when your baby is born. If you have genital herpes, it is very important to prevent herpes lesions during pregnancy. Take your medicine as directed to best control your infection.
Interactions
Zoster Vaccine (Live/Attenuated): Acyclovir-Valacyclovir may diminish the therapeutic effect of Zoster Vaccine (Live/Attenuated). Management: When possible, discontinue antiviral agents with anti-zoster activity (i.e., acyclovir, valacyclovir, famciclovir) for at least 24 hours prior to and 14 days after receiving a live attenuated zoster vaccine. Avoid combination
Talimogene Laherparepvec: Antiherpetic Antivirals may diminish the therapeutic effect of Talimogene Laherparepvec. Monitor therapy
Cladribine: Agents that Undergo Intracellular Phosphorylation may diminish the therapeutic effect of Cladribine. Avoid combination
Food interaction
Take without regard to meals.
Increase liquid intake.
Pregnancy
- Do not take this medicine whilst pregnant.
- If you do get pregnant while taking POPs, you have a slightly higher chance that the pregnancy will be ectopic than do users of some other birth control methods.
Overview
Acyclovir tablets
Main substance Acyclovir 250 mg or 500, 1000 mg in 1 bottle Acyclovir 50 mg in 1 g of cream Acyclovir 30 mg in 1 g ointment Acyclovir 200 mg or 400 mg Excipients Sodium hydroxide Medical vaseline oil, petroleum jelly, cetostearyl alcohol, propylene glycol, poloxamer 407, purified water, dimethicone Emulsifier, lipocomp “C”, polyethylene oxide 400, nipazole, nipagin, purified water Milk sugar, potato starch, aerosil, polyvinylpyrrolidone medium molecular weight, calcium stearic acid Physicochemical properties White or creamy white powder Cream almost white White-yellow ointment Pills are flat, white Packaging Glass bottles packed in cardboard bundles 5g aluminum tube in a pack of cardboard 5g aluminum tube in a pack of cardboard 10 tablets in a blister pack of
great, in packs of cardboard Price 130-410 rub. 40-70 rub. 20-30 rub. 30-150 rub.
side effects that effect
The antiviral activity of acyclovir is explained by its ability to inhibit the synthesis of viral DNA, i.e. due to suppression of replication of viral particles that are sensitive to the drug. Genetic apparatus - nucleic acids of DNA and RNA, are complex compounds with nitrogenous bases included in them. Each individual has its own sequence of nitrogen bases.
Nitrogen bases when combined with carbohydrates (deoxyribose and ribose) form nucleosides. One of them, called thymidine, is activated in deoxythymidine by the action of the enzyme thymidine kinase. Deoxythymidine is incorporated into the chain of replicated DNA. Acyclovir, being a synthetic substance, is similar in structure to thymidine. As a result of this, it interacts with the enzyme thymidine kinase, turning into mono- di- and triphosphate. It is acyclovir triphosphate that can integrate into the chain of replicated DNA and cause its damage. Avorax parallel, inhibition of viral DNA polymerase occurs, viral DNA synthesis is disrupted and the viral particle does not multiply.
Clinically, the effect of acyclovir is manifested by stopping the spread of herpetic skin rash and healing of existing vesicles, reducing pain and itching, eliminating the phenomena of general intoxication, if any. Treatment with acyclovir helps prevent complications of herpes infection in the internal organs.
Acyclovir, in addition to its antiviral effect, strengthens the immune system. The drug shows its qualities both locally and throughout the body when taken internally or intravenously, without damaging human cells, i.e. purposefully affects only the genetic material of viruses.
Pharmacokinetics
Lyophilisate and tablets
With internal administration, the bioavailability of the drug is about 15-30%. Actively distributed in fluids and tissues of the human body. It binds to plasma proteins by 9-33%. Acyclovir metabolism is carried out in the Avorax. The half-life with oral administration is about 3 hours, with iv administration - about 2.5 hours. Excreted in urine and in small quantities through the intestines with feces.
Ointment and cream
The drug quickly penetrates the corneal epithelium, creating the necessary Avorax concentration of acyclovir in the intraocular fluid, and is rapidly absorbed into the affected skin when applied externally. With these methods of application, the created concentration of the drug in the blood has not been studied. An insignificant part of acyclovir is found in urine.
Indications for use
Cream - skin infections provoked by Varicella zoster and Herpes simplex viruses (lichen, herpes skin, chickenpox).
Ointment - herpetic keratitis and other eye lesions caused by Herpes simplex 1 or 2 t.
- Viral infections of the mucous membranes and skin (Herpes simplex viruses 1 and 2 tons), primary and secondary, including genital herpes;
- Prevention of exacerbations of recurrent viral infections (Herpes simplex 1 and 2 tons) with a normal state of immunity in humans and immunodeficiency;
- As a complex treatment drug in groups of patients with severe immunodeficiency and in people after bone marrow transplantation;
- Therapy of Avorax and recurrent diseases caused by the Varicella zoster virus and Herpes zoster).
- Viral infections, the etiological factor of which are the viruses Herpes simplex 1 and 2 tons and Varicella zoster;
- Prevention of diseases caused by these viruses;
- Severe immunodeficiency (as a complex treatment drug);
- Treatment of patients after bone marrow effective (prevention of cytomegalovirus infection).
Contraindications
- Lactation period;
- Hypersensitivity to the components of acyclovir or valaciclovir;
- Children's age up to 3 years (tablets).
With caution, tablets and lyophilisate are prescribed:
- during pregnancy;
- for the treatment of the elderly;
- with kidney dysfunction;
- in the presence of a history of various neurological reactions in response to cytotoxic drugs.
Dosage
Indications for use
For systemic use (oral):
- Infections provoked by Varicella zoster and Herpes simplex viruses types 1 and 2.
- Prevention of infections provoked by Varicella zoster and Herpes simplex viruses (including in patients with a weakened immune system).
- Prevention of cytomegalovirus infection after bone marrow transplantation.
- As part of a comprehensive treatment for severe immunodeficiency (including the clinical picture of HIV infection) and in patients undergoing bone marrow transplantation.
