Selegiline may also be used for purposes not listed in this medication guide.
Anipryl is a drug made in United States. You need a doctor's prescription to buy it. But its analogues can be bought online anywhere in the world without going to a specialist.
Selegiline is a complete analogue of Anipryl. It has the same composition, dosage and methods of use. Also Selegiline has a lower cost compared to Anipryl.
To buy Anipryl, click on the "buy now" button and then in our online store select the medicine and the desired dosage. Follow the instructions below.
Free delivery is valid for purchases from $200. We deliver medicines around the world and provide the best prices.
You can also use a coupon giving a 5% discount.
Side effects
However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk ofside effects.
Warnings
After you stop taking selegiline, you must wait at least 14 days before taking any of the medications listed above.
People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for.
Interactions
Methylene Blue: May enhance the serotonergic effect of Serotonin Modulators. This could result in serotonin syndrome. Avoid combination
Alcohol (Ethyl): May enhance the adverse/toxic effect of Monoamine Oxidase Inhibitors. Avoid combination
Levonordefrin: Monoamine Oxidase Inhibitors may enhance the hypertensive effect of Levonordefrin. Avoid combination
Food interaction
Food increases the oral bioavailability by 3-5 fold.
Pregnancy
- If progestins were given to the mother in that same dosage, serious birth defects could occur.
- However, since drugs do not alway affect humans and animals in the same way, this drug should only be used in pregnancy and breast feeding if it cannot be avoided.
Overview
Name:
Selegilin (Selegilin)
Structure
1 tablet of Selegilin 5 contains:
Selegiline - 5 mg;
Other components: corn starch, lactose monohydrate, citric acid monohydrate, purified talc, magnesium stearate, povidone K30.
1 tablet of the drug Selegilin 10 contains:
Selegiline - 10 mg;
Other components: corn starch, lactose monohydrate, citric acid monohydrate, purified talc, magnesium stearate, povidone K30.
pharmachologic effect
Selegiline is an antiparkinsonian drug that selectively and irreversibly blocks monoamine oxidase B in the brain (this enzyme takes part mainly in the destruction of dopamine). Selegiline inhibits dopamine metabolism, increases its concentration in the central nervous system and prevents the deficiency of this substance in the extrapyramidal system. Selegiline does not affect the activity of serotonin and indirect adrenomimetics.
In the process of selegiline metabolism, derivatives are formed that inhibit the reuptake of dopamine in synapses.
include as part
https://zentherapycenter.com/let-x/xycilan.php complex therapy with levodopa prolongs and enhances its effect (with their combined purpose, the dose
treatment for levodopa can be reduced, which reduces the likelihood of adverse events). It is possible to prescribe selegiline during the use of levodopa only after reaching equilibrium concentrations, if the patient has fluctuations in the effectiveness of Anipryl - taking selegiline is undesirable.
In the digestive tract, selegiline is rapidly absorbed and reaches peak serum levels in 0.5–2 hours. An increase in the bioavailability of the active substance when taken with food is noted. Up to 94% of the active substance in serum is in bound form. Good penetration of selegiline and its derivatives into brain tissue and cerebrospinal fluid is noted.
The metabolism of selegiline passes in the liver (the drug has a pronounced first-pass effect). 3 main derivatives of the drug Selegiline are determined - desmethylselegiline, L-amphetamine and L-methamphetamine.
There was no cumulation of selegiline in the tissues of the body (including with prolonged use).
Derivatives of the drug are excreted mainly by the urinary system (up to 70–85%), the rest is excreted by the intestine.
Indications for use
Selegiline is used in the treatment of Parkinson's disease, as well as in patients with symptomatic parkinsonism.
Selegiline is recommended to be used as monotherapy with an initially established diagnosis. It is also possible to use selegiline tablets in treatment regimens simultaneously with Anipryl and other drugs.
Mode of application
Selegiline is taken orally. Tablets are recommended to be taken in whole with a small volume of liquid. Immediately after the first meal or after breakfast and lunch.
The Anipryl dose of selegiline is 5–10 mg / day (in monotherapy or in combination with a peripheral decarboxylase inhibitor and levodopa).
The maximum maintenance dose of selegiline is 10 mg / open link. The use of higher doses of selegiline tablets is not recommended.
