Proper nutrition and regular exercise are important for the prevention of joint arthrosis (osteoarthritis).

Metabolic changes characteristic of a sedentary lifestyle trigger genetic reprogramming of chondrocytes and destruction of cartilage.

This conclusion was reached by the staff of the University of Surrey (England), who published the results of their incredible work in the journal Nature Reviews Rheumatology. If you learn to control the metabolic mechanisms of osteoarthritis, you can significantly slow down the development of the disease.

Arthrosis is a very urgent problem for Great Britain.

In this country, there are 8.75 million patients, most of whom are women over the age of 40. The fairer sex more than men are predisposed to arthrosis due to genetics and hormones.

Metabolic mechanisms of arthrosis

Normal metabolism is vital for maintaining cartilage function..

Under adverse conditions, the microenvironments of animal and human cells switch to an “emergency” mode of operation and atypical sources of energy.

This phenomenon is accompanied by the accumulation of inflammatory mediators and protein breakdown products, further activation of catabolic processes in the cartilage tissue (destruction processes). In the past few years, scientists from different countries have demonstrated that metabolic disorders play a key role in the onset and progression of arthrosis..

With a sedentary lifestyle, the ability of chondrocytes to get energy from glucose is disrupted, they switch to alternative nutrition. As a result, an excess of unused glucose accumulates, which is transformed into lactic acid. This is just one of the mechanisms discovered by the authors..

“For a long time, arthrosis was considered a disease of worn joints, which should become an inevitable part of aging. This does not coincide with what we saw during our experiments. Do not underestimate the nutrition and lifestyle that affect the metabolism of every cell, organ and tissue, leading to the development of serious diseases, ”Ali Mobasheri, Professor of Musculoskeletal Physiology at the University of Surrey.

The authors emphasized that further studies should show us effective ways to control these metabolic changes. Perhaps this will be a new, revolutionary approach to the prevention and treatment of arthrosis.

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